CD33 and CXCL9

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CD33	CXCL9
Description		CD33 molecule	C-X-C motif chemokine ligand 9
Image			No pdb structure
GO Annotations	Cellular Component	Peroxisome Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Specific Granule Membrane Tertiary Granule Membrane	Extracellular Region Extracellular Space External Side Of Plasma Membrane
	Molecular Function	Protein Binding Protein Tyrosine Phosphatase Activator Activity Protein Phosphatase Binding Carbohydrate Binding Sialic Acid Binding Signaling Receptor Activity	Cytokine Activity Protein Binding Chemokine Activity CXCR Chemokine Receptor Binding CXCR3 Chemokine Receptor Binding
	Biological Process	Immune Response-inhibiting Signal Transduction Cell Adhesion Signal Transduction Cell-cell Signaling Negative Regulation Of Cell Population Proliferation Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Fc-gamma Receptor Signaling Pathway Positive Regulation Of Protein Secretion Cell-cell Adhesion Negative Regulation Of Monocyte Activation	Chemotaxis Defense Response Inflammatory Response Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Bacterium Neutrophil Chemotaxis Killing Of Cells Of Another Organism Regulation Of Cell Population Proliferation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Positive Regulation Of Myoblast Fusion
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		Gemtuzumab ozogamicin AVE9633
Diseases
GWAS		Alzheimer's disease ( 18976728 31473137) Alzheimer's disease (late onset) ( 21460841 24162737 28714976 30617256) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Basophil count ( 32888494) Blood protein levels ( 30072576) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Eosinophil count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) HIV-1 susceptibility ( 25786224) Lymphocyte count ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Triacylglyceride levels ( 31551469) White blood cell count ( 27863252 32888494)	Hippocampal volume ( 29274321) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)
Interacting Genes		21 interacting genes: BMP10 C3orf52 CXCL9 CYB5B EMD GIMAP5 HERC3 KRT31 KRT35 KRT40 PTPN11 PTPN6 RPRM SCD SRC THSD7A TMBIM1 TMEM100 TMEM243 TNMD UBIAD1	76 interacting genes: AMIGO1 AQP6 ATP1B4 BMF BSCL2 BTNL9 C16orf92 CCL11 CCL13 CCL2 CCL21 CCL26 CCL28 CCL5 CCR3 CD33 CHODL CLDN2 CLDN5 CLDN7 CLEC17A CLEC2D CLEC4E CLEC7A CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCR3 DPP4 EPGN EREG FBXO7 FCGR2A FFAR2 FNDC9 FUT7 GJB1 GORAB GPR42 IFNGR2 ITM2C KASH5 KIR2DL3 LDLRAD1 LEUTX LRRC25 LSMEM2 MR1 MTIF3 MUC1 NEMP1 PAX8 PF4 PPBP PTPN5 RHCG SFTPC SLC10A1 SLC39A1 SSMEM1 SUSD3 SYNE4 TM4SF18 TMED5 TMEM106C TMEM234 TMEM237 TMEM31 TMPRSS2 TNFSF14 TNFSF8 TSPAN18 XCL1
Entrez ID		945	4283
HPRD ID		01165	03416
Ensembl ID		ENSG00000105383	ENSG00000138755
Uniprot IDs		P20138 Q546G0	Q07325
PDB IDs		5IHB 5J06 5J0B 6D48 6D49 6D4A 6TL8 7AW6
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Neutrophil Activation Regulation Of Neutrophil Activation Neutrophil Activation Involved In Immune Response Neutrophil Activation T Cell Costimulation Structural Constituent Of Skin Epidermis Myeloid Cell Development Intermediate Filament Organization Non-membrane Spanning Protein Tyrosine Phosphatase Activity Tissue Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Cell Differentiation Supramolecular Fiber Organization Peptidyl-tyrosine Dephosphorylation Cellular Developmental Process Cellular Response To Growth Factor Stimulus Platelet Formation Megakaryocyte Development Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Myeloid Leukocyte Activation Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Growth Factor Morphogenesis Of An Epithelium Regulation Of Protein Export From Nucleus TMEM240-body Intermediate Filament Cytoskeleton Organization Cell Activation Involved In Immune Response Leukocyte Activation Involved In Immune Response SH2 Domain Binding Epididymis Development Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Monounsaturated Fatty Acid Biosynthetic Process Vitamin K Biosynthetic Process Menaquinone Biosynthetic Process Epithelial Cell Differentiation Structural Molecule Activity Regulation Of Type I Interferon-mediated Signaling Pathway Hemopoiesis Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Anatomical Structure Morphogenesis Cytokine-mediated Signaling Pathway Phosphotyrosine Residue Binding Regulation Of Cell Adhesion Mediated By Integrin Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway	Chemokine Activity Cell Chemotaxis Leukocyte Chemotaxis Chemotaxis Locomotion Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Leukocyte Migration Cytokine Activity Antimicrobial Humoral Response Chemokine-mediated Signaling Pathway Mononuclear Cell Migration Granulocyte Chemotaxis Inflammatory Response Granulocyte Migration Killing Of Cells Of Another Organism Immune Response Immune System Process Humoral Immune Response Myeloid Leukocyte Migration Defense Response Cell Killing Lymphocyte Migration T Cell Migration Lymphocyte Chemotaxis CCR Chemokine Receptor Binding Cell Migration T Cell Chemotaxis Eosinophil Chemotaxis Cytokine-mediated Signaling Pathway Regulation Of Leukocyte Migration Eosinophil Migration Chemokine Receptor Binding Defense Response To Symbiont Cell Motility Defense Response To Other Organism Positive Regulation Of Chemotaxis Regulation Of Lymphocyte Chemotaxis CXCR Chemokine Receptor Binding Regulation Of Chemotaxis Regulation Of T Cell Chemotaxis Response To Other Organism Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Protein Binding Positive Regulation Of T Cell Migration Positive Regulation Of Leukocyte Migration Regulation Of Lymphocyte Migration Positive Regulation Of Lymphocyte Migration Regulation Of Immune System Process G Protein-coupled Receptor Signaling Pathway
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