CD33 and TMBIM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CD33	TMBIM1
Description		CD33 molecule	transmembrane BAX inhibitor motif containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Peroxisome Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Specific Granule Membrane Tertiary Granule Membrane	Golgi Membrane Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Endosome Membrane Membrane Specific Granule Membrane Extracellular Exosome
	Molecular Function	Protein Binding Protein Tyrosine Phosphatase Activator Activity Protein Phosphatase Binding Carbohydrate Binding Sialic Acid Binding Signaling Receptor Activity	Death Receptor Binding Calcium Channel Activity Protein Binding
	Biological Process	Immune Response-inhibiting Signal Transduction Cell Adhesion Signal Transduction Cell-cell Signaling Negative Regulation Of Cell Population Proliferation Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Fc-gamma Receptor Signaling Pathway Positive Regulation Of Protein Secretion Cell-cell Adhesion Negative Regulation Of Monocyte Activation	Negative Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Calcium Ion Transmembrane Transport Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Fas Signaling Pathway Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Blood Vessel Remodeling
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation	Neutrophil degranulation
Drugs		Gemtuzumab ozogamicin AVE9633
Diseases
GWAS		Alzheimer's disease ( 18976728 31473137) Alzheimer's disease (late onset) ( 21460841 24162737 28714976 30617256) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Basophil count ( 32888494) Blood protein levels ( 30072576) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Eosinophil count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) HIV-1 susceptibility ( 25786224) Lymphocyte count ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Triacylglyceride levels ( 31551469) White blood cell count ( 27863252 32888494)	Colorectal cancer ( 28960316) Colorectal cancer or advanced adenoma ( 30510241) Gallstone disease ( 30504769) Glycated hemoglobin levels ( 34059833) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 23128233 28067908) Red cell distribution width ( 27863252) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		21 interacting genes: BMP10 C3orf52 CXCL9 CYB5B EMD GIMAP5 HERC3 KRT31 KRT35 KRT40 PTPN11 PTPN6 RPRM SCD SRC THSD7A TMBIM1 TMEM100 TMEM243 TNMD UBIAD1	13 interacting genes: B3GALNT2 BIK CD33 F2RL1 GGT6 PROK2 RCHY1 RIC3 SLC10A1 SOCS5 TMEM242 TRIM55 TRIM63
Entrez ID		945	64114
HPRD ID		01165	17884
Ensembl ID		ENSG00000105383	ENSG00000135926
Uniprot IDs		P20138 Q546G0	B3KSM0 B4DUD2 Q969X1
PDB IDs		5IHB 5J06 5J0B 6D48 6D49 6D4A 6TL8 7AW6
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Neutrophil Activation Regulation Of Neutrophil Activation Neutrophil Activation Involved In Immune Response Neutrophil Activation T Cell Costimulation Structural Constituent Of Skin Epidermis Myeloid Cell Development Intermediate Filament Organization Non-membrane Spanning Protein Tyrosine Phosphatase Activity Tissue Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Cell Differentiation Supramolecular Fiber Organization Peptidyl-tyrosine Dephosphorylation Cellular Developmental Process Cellular Response To Growth Factor Stimulus Platelet Formation Megakaryocyte Development Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Myeloid Leukocyte Activation Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Growth Factor Morphogenesis Of An Epithelium Regulation Of Protein Export From Nucleus TMEM240-body Intermediate Filament Cytoskeleton Organization Cell Activation Involved In Immune Response Leukocyte Activation Involved In Immune Response SH2 Domain Binding Epididymis Development Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Monounsaturated Fatty Acid Biosynthetic Process Vitamin K Biosynthetic Process Menaquinone Biosynthetic Process Epithelial Cell Differentiation Structural Molecule Activity Regulation Of Type I Interferon-mediated Signaling Pathway Hemopoiesis Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Anatomical Structure Morphogenesis Cytokine-mediated Signaling Pathway Phosphotyrosine Residue Binding Regulation Of Cell Adhesion Mediated By Integrin Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
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