CD33 and RPRM

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CD33	RPRM
Description		CD33 molecule	reprimo, TP53 dependent G2 arrest mediator homolog
Image			No pdb structure
GO Annotations	Cellular Component	Peroxisome Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Specific Granule Membrane Tertiary Granule Membrane	Cytoplasm Membrane
	Molecular Function	Protein Binding Protein Tyrosine Phosphatase Activator Activity Protein Phosphatase Binding Carbohydrate Binding Sialic Acid Binding Signaling Receptor Activity	Protein Binding
	Biological Process	Immune Response-inhibiting Signal Transduction Cell Adhesion Signal Transduction Cell-cell Signaling Negative Regulation Of Cell Population Proliferation Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Fc-gamma Receptor Signaling Pathway Positive Regulation Of Protein Secretion Cell-cell Adhesion Negative Regulation Of Monocyte Activation	Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation
Drugs		Gemtuzumab ozogamicin AVE9633
Diseases
GWAS		Alzheimer's disease ( 18976728 31473137) Alzheimer's disease (late onset) ( 21460841 24162737 28714976 30617256) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Basophil count ( 32888494) Blood protein levels ( 30072576) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Eosinophil count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) HIV-1 susceptibility ( 25786224) Lymphocyte count ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Triacylglyceride levels ( 31551469) White blood cell count ( 27863252 32888494)	Anti-saccade response ( 29064472) Blood trace element (Zn levels) ( 23720494) Heel bone mineral density ( 30598549) Lung cancer ( 28604730) Recurrent major depressive disorder x sex interaction ( 34099189)
Interacting Genes		21 interacting genes: BMP10 C3orf52 CXCL9 CYB5B EMD GIMAP5 HERC3 KRT31 KRT35 KRT40 PTPN11 PTPN6 RPRM SCD SRC THSD7A TMBIM1 TMEM100 TMEM243 TNMD UBIAD1	80 interacting genes: ADGRG3 AMIGO1 AQP6 ARFIP1 ASGR2 BNIP3 BSCL2 BTNL9 C16orf54 CD33 CD53 CD69 CLDN5 CLDN7 CLDN9 CLEC17A CLEC2D COQ8A CREB3 CXorf66 EHHADH EMP1 FAM209A FAM210B FATE1 FBXL19 FCGR1A FFAR2 FGD2 FKBP7 FNDC9 GAD2 GJA5 GJB3 GJB5 GNG13 GPR37L1 GPR42 GPX8 HHLA2 HIP1 HSD17B13 KCNJ6 LAPTM5 LHFPL5 LMNA LPAR6 MPP1 MS4A4A MTIF3 OPRD1 OPRM1 PBX3 PDZK1IP1 PLEKHF2 PNKP SCAND1 SDCBP SENP2 SLC18A1 SLC38A1 SMIM3 SNX11 SNX12 SNX3 SPACA1 SPCS1 STOM SUSD3 SYT16 TM4SF18 TMEM106C TMEM237 TMEM79 TMEM80 TMEM86B TSPO2 TTPA WDFY2 ZDHHC22
Entrez ID		945	56475
HPRD ID		01165	18002
Ensembl ID		ENSG00000105383	ENSG00000177519
Uniprot IDs		P20138 Q546G0	Q9NS64
PDB IDs		5IHB 5J06 5J0B 6D48 6D49 6D4A 6TL8 7AW6
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Neutrophil Activation Regulation Of Neutrophil Activation Neutrophil Activation Involved In Immune Response Neutrophil Activation T Cell Costimulation Structural Constituent Of Skin Epidermis Myeloid Cell Development Intermediate Filament Organization Non-membrane Spanning Protein Tyrosine Phosphatase Activity Tissue Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Cell Differentiation Supramolecular Fiber Organization Peptidyl-tyrosine Dephosphorylation Cellular Developmental Process Cellular Response To Growth Factor Stimulus Platelet Formation Megakaryocyte Development Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Myeloid Leukocyte Activation Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Growth Factor Morphogenesis Of An Epithelium Regulation Of Protein Export From Nucleus TMEM240-body Intermediate Filament Cytoskeleton Organization Cell Activation Involved In Immune Response Leukocyte Activation Involved In Immune Response SH2 Domain Binding Epididymis Development Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Monounsaturated Fatty Acid Biosynthetic Process Vitamin K Biosynthetic Process Menaquinone Biosynthetic Process Epithelial Cell Differentiation Structural Molecule Activity Regulation Of Type I Interferon-mediated Signaling Pathway Hemopoiesis Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Anatomical Structure Morphogenesis Cytokine-mediated Signaling Pathway Phosphotyrosine Residue Binding Regulation Of Cell Adhesion Mediated By Integrin Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway	Membrane Protein Binding Plasma Membrane Negative Regulation Of Early Endosome To Late Endosome Transport Connexin Complex Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Gap Junction Channel Activity Endoplasmic Reticulum Phosphatidylinositol Binding External Side Of Plasma Membrane Gap Junction Gamma-aminobutyric Acid Biosynthetic Process Phosphatidylinositol Phosphate Binding Late Endosome To Golgi Transport
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