FHL3 and EIF4EBP2

Number of citations of the paper that reports this interaction (PubMedID 30217970)
38

Data Source:
BioGRID (two hybrid)

		FHL3	EIF4EBP2
Description		four and a half LIM domains 3	eukaryotic translation initiation factor 4E binding protein 2
Image
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Focal Adhesion Z Disc	Nucleus Cytoplasm Neuronal Ribonucleoprotein Granule Postsynapse
	Molecular Function	Transcription Coregulator Activity Actin Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Repressor Activity
	Biological Process	Muscle Organ Development Actin Cytoskeleton Organization	Translation Regulation Of Translation Memory Insulin Receptor Signaling Pathway Negative Regulation Of Translation TOR Signaling Social Behavior Negative Regulation Of Translational Initiation Regulation Of Synaptic Plasticity Modulation Of Chemical Synaptic Transmission
Pathways
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778 33020668) Pulse pressure ( 30578418)
Interacting Genes		181 interacting genes: A1CF ACTB ADAM15 ADAMTSL4 AIMP2 AMBP ANKHD1 ARHGEF10 ARID5A ASCL4 BARX2 C1orf94 CASS4 CBX8 CCDC198 CCND3 CDC25B CDC42EP1 CDKN1A CDKN2D CHEK2 CIMAP1B CLCN2 CNNM3 CNOT7 CORO1A CREB5 CRIP3 CRYBA2 CSF1 CTBP2 CYSRT1 DCDC2B DLGAP4 DMRT3 DUX4L9 E2F8 EFCAB12 EIF4EBP2 EPHA10 EPM2AIP1 ERBB3 EXOSC1 EXOSC5 FADS6 FAM110A FAM222B FAM90A1 FBXL18 FHL2 FOS FOSL2 FOXN4 GARIN6 GATA1 GATA2 GCM2 GUCD1 HAPLN2 HIPK1 HOXA1 HSF2BP HYAL2 HYCC1 IHO1 IKZF3 ITGA7 ITGB5 KANK2 KIDINS220 KIRREL2 KLF12 KLF3 KLF8 KPRP KRTAP12-1 KRTAP12-2 KTI12 LASP1 LATS2 LHB LMO2 LMO4 LNX1 LNX2 MAPK1 MED15 MMP14 MORF4L1 MPZL1 MRM3 MRPL27 MRRF MSRB3 MTA1 MTUS2 MYBPC1 MYBPHL MYCBP2 MYOZ3 MYPOP MZF1 NDUFAB1 NFKBIB NPRL3 P4HA2 PAK5 PATL1 PHC2 PHF21A PIAS1 PIERCE1 PKP2 PLEKHF2 PLEKHG4B POLR1H PPIG PRR35 PRR5L PTPN6 QKI QRICH1 RAB40B RAD21 RASL12 RBM42 RFX3 RFX6 RHEBL1 RSPH14 RYBP SAP30BP SAXO1 SAXO4 SBF2 SDCBP SH3GLB2 SHE SLAIN1 SLC25A46 SLC44A3 SLU7 SMAD2 SMAD3 SMAD4 SNRPB SNRPC SNRPG SPATA8 SPMAP2 SREBF2 SRF SRGN SUPT5H TBC1D22B THAP7 TLE5 TMEM108 TMEM14B TMSB4X TMX3 TRAF3IP2 TRIM27 TRIP6 TRO TSGA10IP TTLL10 TUBA3E TYK2 TYMSOS UBE2I UBE2Q1 VWC2L WDR25 WNK1 YPEL3 ZCCHC14 ZFP36 ZNF417 ZNF512B ZNF587	6 interacting genes: CDK4 EIF4E FHL3 LSM3 MTOR RPTOR
Entrez ID		2275	1979
HPRD ID		09101	03747
Ensembl ID		ENSG00000183386	ENSG00000148730
Uniprot IDs		Q13643 Q96C98	Q13542
PDB IDs		1WYH 2CUQ 2EHE	2MX4 3AM7
Enriched GO Terms of Interacting Partners?		Protein Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Ventral Spinal Cord Interneuron Differentiation Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Chromatin Binding Positive Regulation Of Biosynthetic Process Regulation Of MiRNA Metabolic Process Transcription Coregulator Binding DNA-binding Transcription Factor Activity Regulation Of Primary Metabolic Process DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Transcription Phosphatase Binding Positive Regulation Of Macromolecule Metabolic Process Cell Population Proliferation Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of MiRNA Transcription Identical Protein Binding SMAD Protein Complex Sequence-specific Double-stranded DNA Binding Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Chromatin Positive Regulation Of MiRNA Metabolic Process Heteromeric SMAD Protein Complex Myelination DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Axon Ensheathment	Positive Regulation Of Pentose-phosphate Shunt TORC1 Complex Regulation Of Pentose-phosphate Shunt Regulation Of NADP Metabolic Process Negative Regulation Of Autophagy Cellular Response To L-leucine Positive Regulation Of Mitotic Cell Cycle Response To L-leucine Positive Regulation Of Transcription By RNA Polymerase III Negative Regulation Of Translation Serine/threonine Protein Kinase Complex Positive Regulation Of Glycolytic Process Regulation Of Transcription By RNA Polymerase III Positive Regulation Of ATP Metabolic Process Cellular Response To Oxygen-containing Compound Negative Regulation Of Translational Initiation Cellular Response To Osmotic Stress Positive Regulation Of Translational Initiation Positive Regulation Of Cell Cycle Regulation Of Glycolytic Process Translation Negative Regulation Of Catabolic Process Regulation Of Autophagy Regulation Of Carbohydrate Catabolic Process Positive Regulation Of TORC1 Signaling TORC1 Signaling Regulation Of Osteoclast Differentiation Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Eukaryotic Initiation Factor 4G Binding Regulation Of Translation Regulation Of ATP Metabolic Process TOR Signaling Regulation Of Amide Metabolic Process Response To Osmotic Stress Regulation Of Purine Nucleotide Metabolic Process Cellular Response To Amino Acid Stimulus Regulation Of Cell Size Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Positive Regulation Of TOR Signaling Cytoplasmic Stress Granule Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle P-body Autophagosome Assembly Regulation Of TORC1 Signaling Positive Regulation Of Lipid Biosynthetic Process Autophagosome Organization Regulation Of Translational Initiation Positive Regulation Of Cell Cycle Phase Transition
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