FHL3 and CLCN2

Number of citations of the paper that reports this interaction (PubMedID 26871637)
43

Data Source:
BioGRID (two hybrid)

		FHL3	CLCN2
Description		four and a half LIM domains 3	chloride voltage-gated channel 2
Image
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Focal Adhesion Z Disc	Plasma Membrane Membrane Basolateral Plasma Membrane Axon Dendrite Dendritic Spine Membrane Monoatomic Ion Channel Complex Chloride Channel Complex Cell Projection Axon Initial Segment Perikaryon Myelin Sheath Synapse Postsynaptic Membrane Astrocyte End-foot
	Molecular Function	Transcription Coregulator Activity Actin Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding Voltage-gated Monoatomic Anion Channel Activity Chloride Transmembrane Transporter Activity Chloride Channel Regulator Activity Volume-sensitive Chloride Channel Activity
	Biological Process	Muscle Organ Development Actin Cytoskeleton Organization	Monoatomic Ion Transport Chloride Transport Phagocytosis, Engulfment Stabilization Of Membrane Potential Lung Development Regulation Of Aldosterone Biosynthetic Process Monoatomic Ion Transmembrane Transport Positive Regulation Of Oligodendrocyte Differentiation Transmembrane Transport Retina Development In Camera-type Eye Regulation Of Resting Membrane Potential Cell Differentiation Involved In Salivary Gland Development Regulation Of Biological Quality Cellular Hypotonic Response Acinar Cell Differentiation Monoatomic Anion Transmembrane Transport Regulation Of Membrane Depolarization During Action Potential Chloride Transmembrane Transport
Pathways			Stimuli-sensing channels
Drugs			Lubiprostone Cobiprostone
Diseases			Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
GWAS		Coronary artery disease ( 29212778 33020668) Pulse pressure ( 30578418)	General cognitive ability ( 29844566)
Interacting Genes		181 interacting genes: A1CF ACTB ADAM15 ADAMTSL4 AIMP2 AMBP ANKHD1 ARHGEF10 ARID5A ASCL4 BARX2 C1orf94 CASS4 CBX8 CCDC198 CCND3 CDC25B CDC42EP1 CDKN1A CDKN2D CHEK2 CIMAP1B CLCN2 CNNM3 CNOT7 CORO1A CREB5 CRIP3 CRYBA2 CSF1 CTBP2 CYSRT1 DCDC2B DLGAP4 DMRT3 DUX4L9 E2F8 EFCAB12 EIF4EBP2 EPHA10 EPM2AIP1 ERBB3 EXOSC1 EXOSC5 FADS6 FAM110A FAM222B FAM90A1 FBXL18 FHL2 FOS FOSL2 FOXN4 GARIN6 GATA1 GATA2 GCM2 GUCD1 HAPLN2 HIPK1 HOXA1 HSF2BP HYAL2 HYCC1 IHO1 IKZF3 ITGA7 ITGB5 KANK2 KIDINS220 KIRREL2 KLF12 KLF3 KLF8 KPRP KRTAP12-1 KRTAP12-2 KTI12 LASP1 LATS2 LHB LMO2 LMO4 LNX1 LNX2 MAPK1 MED15 MMP14 MORF4L1 MPZL1 MRM3 MRPL27 MRRF MSRB3 MTA1 MTUS2 MYBPC1 MYBPHL MYCBP2 MYOZ3 MYPOP MZF1 NDUFAB1 NFKBIB NPRL3 P4HA2 PAK5 PATL1 PHC2 PHF21A PIAS1 PIERCE1 PKP2 PLEKHF2 PLEKHG4B POLR1H PPIG PRR35 PRR5L PTPN6 QKI QRICH1 RAB40B RAD21 RASL12 RBM42 RFX3 RFX6 RHEBL1 RSPH14 RYBP SAP30BP SAXO1 SAXO4 SBF2 SDCBP SH3GLB2 SHE SLAIN1 SLC25A46 SLC44A3 SLU7 SMAD2 SMAD3 SMAD4 SNRPB SNRPC SNRPG SPATA8 SPMAP2 SREBF2 SRF SRGN SUPT5H TBC1D22B THAP7 TLE5 TMEM108 TMEM14B TMSB4X TMX3 TRAF3IP2 TRIM27 TRIP6 TRO TSGA10IP TTLL10 TUBA3E TYK2 TYMSOS UBE2I UBE2Q1 VWC2L WDR25 WNK1 YPEL3 ZCCHC14 ZFP36 ZNF417 ZNF512B ZNF587	4 interacting genes: ATXN1 FHL3 PPP1CA UBQLN1
Entrez ID		2275	1181
HPRD ID		09101	02782
Ensembl ID		ENSG00000183386	ENSG00000114859
Uniprot IDs		Q13643 Q96C98	P51788
PDB IDs		1WYH 2CUQ 2EHE	7XF5 7XJA 8GQU 8TA2 8TA3 8TA4 8TA5 8TA6
Enriched GO Terms of Interacting Partners?		Protein Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Ventral Spinal Cord Interneuron Differentiation Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Chromatin Binding Positive Regulation Of Biosynthetic Process Regulation Of MiRNA Metabolic Process Transcription Coregulator Binding DNA-binding Transcription Factor Activity Regulation Of Primary Metabolic Process DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Transcription Phosphatase Binding Positive Regulation Of Macromolecule Metabolic Process Cell Population Proliferation Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of MiRNA Transcription Identical Protein Binding SMAD Protein Complex Sequence-specific Double-stranded DNA Binding Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Chromatin Positive Regulation Of MiRNA Metabolic Process Heteromeric SMAD Protein Complex Myelination DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Axon Ensheathment	RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process Positive Regulation Of Termination Of DNA-templated Transcription Glycogen Granule Positive Regulation Of Termination Of RNA Polymerase II Transcription PTW/PP1 Phosphatase Complex RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Postsynapse Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Histone H4K5ac Reader Activity Histone H3K14ac Reader Activity Histone H4K12ac Reader Activity Acetylation-dependent Protein Binding Positive Regulation Of T-helper 17 Cell Lineage Commitment Poly(G) Binding POZ Domain Binding Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway
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