FHL3 and CSF1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		FHL3	CSF1
Gene Name		four and a half LIM domains 3	colony stimulating factor 1 (macrophage)
Image
Gene Ontology Annotations	Cellular Component	Stress Fiber Nucleus Focal Adhesion Z Disc	Extracellular Space Plasma Membrane Membrane Integral Component Of Membrane Receptor Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Zinc Ion Binding	Cytokine Activity Macrophage Colony-stimulating Factor Receptor Binding Growth Factor Activity Protein Homodimerization Activity
	Biological Process	Muscle Organ Development Actin Cytoskeleton Organization	Ossification Positive Regulation Of Cell-matrix Adhesion Osteoclast Proliferation Developmental Process Involved In Reproduction Inflammatory Response Cell Proliferation Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Hemopoiesis Cell Differentiation Macrophage Differentiation Regulation Of Ossification Osteoclast Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Multicellular Organism Growth Monocyte Activation Odontogenesis Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Monocyte Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Ras Protein Signal Transduction Homeostasis Of Number Of Cells Within A Tissue Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Fat Development Mammary Duct Terminal End Bud Growth
Pathways
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661) Paget's disease ( 21623375 20436471)
Protein-Protein Interactions		88 interactors: A1CF ACTB ADAM15 ADAMTSL4 AIMP2 AMBP C14orf105 C9orf116 CDC25B CDC42EP1 CNNM3 CORO1A CSF1 CTBP2 DCDC2B E2F8 EFCAB12 EPHA10 EPM2AIP1 FAM154A FAM71C FAM90A1 FBXL18 FHL2 FHL5 FOSL2 GATA2 GCM2 HIPK1 HYAL2 ITGA7 KIRREL2 KLF3 KLF8 KRTAP12-1 KRTAP12-2 KTI12 LASP1 LMO2 LNX1 MAPK1 MED15 MPZL1 MRPL27 MYBPC1 MYBPHL MZF1 NPRL3 P4HA2 PAK7 PATL1 PHC2 PHF21A PLEKHF2 PPIG PTPN6 QRICH1 RAD21 RBM42 RFX3 RFX6 RHEBL1 RNMTL1 SAP30BP SLAIN1 SLC25A46 SLC44A3 SMAD2 SMAD3 SMAD4 SNRPG SREBF2 SRF TMX3 TRAF3IP2 TRIM27 TRIP6 TRO TTLL10 TYK2 TYMSOS UBE2I UBE2Q1 WNK1 YPEL3 ZNF417 ZNF512B ZNRD1	10 interactors: CSF1R FHL3 GAB3 HLA-B NOTCH2NL PIK3R2 SGTA SLA2 SOCS1 TNF
Entrez ID		2275	1435
HPRD ID		09101	00388
Ensembl ID		ENSG00000183386	ENSG00000184371
Uniprot IDs		Q13643 Q96C98	P09603
PDB IDs		1WYH 2CUQ 2EHE	1HMC 3UEZ 3UF2 4ADF 4FA8
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Transcription, DNA-templated Gene Expression RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process SMAD Protein Complex Assembly Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Cellular Process Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cell Proliferation Negative Regulation Of RNA Biosynthetic Process Tissue Development Positive Regulation Of Cellular Metabolic Process Cell Death Death Multicellular Organismal Homeostasis Positive Regulation Of Epithelial To Mesenchymal Transition Endoderm Development Negative Regulation Of Cell Growth Embryonic Organ Development Positive Regulation Of Metabolic Process Primary MiRNA Processing Organ Development Apoptotic Process	Immune Response Immune System Process Regulation Of Immune Response Myeloid Leukocyte Differentiation Cytokine-mediated Signaling Pathway Macrophage Differentiation Cell Surface Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Transcription Factor Import Into Nucleus Response To Cytokine Myeloid Cell Differentiation Positive Regulation Of Chemokine Production Osteoclast Differentiation Innate Immune Response Regulation Of Kinase Activity Regulation Of Chemokine Production Cellular Response To Amino Acid Stimulus Leukocyte Differentiation Positive Regulation Of Protein Transport Positive Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Immune System Process Negative Regulation Of Branching Involved In Lung Morphogenesis Negative Regulation Of L-glutamate Transport Regulation Of Cellular Amino Acid Metabolic Process Cellular Response To Organic Substance Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Positive Regulation Of Cytokine Secretion Regulation Of Transcription Factor Import Into Nucleus Regulation Of JAK-STAT Cascade Positive Regulation Of Protein Import Into Nucleus Interferon-gamma-mediated Signaling Pathway Cellular Response To Organonitrogen Compound Regulation Of Interleukin-6 Production Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Macrophage Colony-stimulating Factor Signaling Pathway Response To Gold Nanoparticle Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Cellular Ketone Metabolic Process Response To Amino Acid Cellular Response To Interferon-gamma Positive Regulation Of Adaptive Immune Response
Tagcloud ?		accompanied adhesion anchorage antiproliferative arrest b1 cip1 downregulated g1 g2 half implicated interfering knockdown lim marked marker member mobility p21 progression regulator sirna suppressed thereby transduction unclear waf1	bands constructs ddpcr encodes escape exceptions finger g401 genitourinary greatly hek293 indeed influences kidneys lesser none northern saos similarity steady tetracycline thousand transfected transfection tumorigenicity unambiguously verified wilms wt1
Tagcloud (Difference) ?		accompanied adhesion anchorage antiproliferative arrest b1 cip1 downregulated g1 g2 half implicated interfering knockdown lim marked marker member mobility p21 progression regulator sirna suppressed thereby transduction unclear waf1	bands constructs ddpcr encodes escape exceptions finger g401 genitourinary greatly hek293 indeed influences kidneys lesser none northern saos similarity steady tetracycline thousand transfected transfection tumorigenicity unambiguously verified wilms wt1
Tagcloud (Intersection) ?