FHL3 and CORO1A

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		FHL3	CORO1A
Description		four and a half LIM domains 3	coronin 1A
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Focal Adhesion Z Disc	Immunological Synapse Phagocytic Cup Nucleus Cytoplasm Early Endosome Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Cell Cortex Actin Cytoskeleton Membrane Lamellipodium Axon Phagocytic Vesicle Membrane Cortical Actin Cytoskeleton Cell Leading Edge Cytoplasmic Vesicle Protein-containing Complex Synapse Phagocytic Vesicle Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Transcription Coregulator Activity Actin Binding Protein Binding Zinc Ion Binding Metal Ion Binding	RNA Binding Actin Binding Actin Monomer Binding Protein Binding Cytoskeletal Protein Binding Myosin Heavy Chain Binding Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol 3-kinase Binding Actin Filament Binding
	Biological Process	Muscle Organ Development Actin Cytoskeleton Organization	Immunological Synapse Formation Phagolysosome Assembly Calcium Ion Transport Vesicle Fusion Phagocytosis Actin Filament Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Cell Shape Epithelial Cell Migration Cell Migration Actin Cytoskeleton Organization Leukocyte Chemotaxis Regulation Of Actin Filament Polymerization Negative Regulation Of Vesicle Fusion Cell-substrate Adhesion Uropod Organization Regulation Of Actin Cytoskeleton Organization Response To Cytokine Nerve Growth Factor Signaling Pathway T Cell Proliferation Positive Regulation Of T Cell Proliferation T Cell Activation T Cell Homeostasis Natural Killer Cell Degranulation Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of T Cell Activation Positive Chemotaxis Negative Regulation Of Actin Nucleation Negative Regulation Of Cellular Component Organization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Neuron Apoptotic Process Establishment Of Localization In Cell Early Endosome To Recycling Endosome Transport Cellular Response To Interleukin-4 T Cell Migration Thymocyte Migration Positive Regulation Of T Cell Migration
Pathways			Prevention of phagosomal-lysosomal fusion
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778 33020668) Pulse pressure ( 30578418)	Brain morphology (MOSTest) ( 32665545) Hodgkin's lymphoma ( 30194254) Tonsillectomy ( 27182965 28928442)
Interacting Genes		181 interacting genes: A1CF ACTB ADAM15 ADAMTSL4 AIMP2 AMBP ANKHD1 ARHGEF10 ARID5A ASCL4 BARX2 C1orf94 CASS4 CBX8 CCDC198 CCND3 CDC25B CDC42EP1 CDKN1A CDKN2D CHEK2 CIMAP1B CLCN2 CNNM3 CNOT7 CORO1A CREB5 CRIP3 CRYBA2 CSF1 CTBP2 CYSRT1 DCDC2B DLGAP4 DMRT3 DUX4L9 E2F8 EFCAB12 EIF4EBP2 EPHA10 EPM2AIP1 ERBB3 EXOSC1 EXOSC5 FADS6 FAM110A FAM222B FAM90A1 FBXL18 FHL2 FOS FOSL2 FOXN4 GARIN6 GATA1 GATA2 GCM2 GUCD1 HAPLN2 HIPK1 HOXA1 HSF2BP HYAL2 HYCC1 IHO1 IKZF3 ITGA7 ITGB5 KANK2 KIDINS220 KIRREL2 KLF12 KLF3 KLF8 KPRP KRTAP12-1 KRTAP12-2 KTI12 LASP1 LATS2 LHB LMO2 LMO4 LNX1 LNX2 MAPK1 MED15 MMP14 MORF4L1 MPZL1 MRM3 MRPL27 MRRF MSRB3 MTA1 MTUS2 MYBPC1 MYBPHL MYCBP2 MYOZ3 MYPOP MZF1 NDUFAB1 NFKBIB NPRL3 P4HA2 PAK5 PATL1 PHC2 PHF21A PIAS1 PIERCE1 PKP2 PLEKHF2 PLEKHG4B POLR1H PPIG PRR35 PRR5L PTPN6 QKI QRICH1 RAB40B RAD21 RASL12 RBM42 RFX3 RFX6 RHEBL1 RSPH14 RYBP SAP30BP SAXO1 SAXO4 SBF2 SDCBP SH3GLB2 SHE SLAIN1 SLC25A46 SLC44A3 SLU7 SMAD2 SMAD3 SMAD4 SNRPB SNRPC SNRPG SPATA8 SPMAP2 SREBF2 SRF SRGN SUPT5H TBC1D22B THAP7 TLE5 TMEM108 TMEM14B TMSB4X TMX3 TRAF3IP2 TRIM27 TRIP6 TRO TSGA10IP TTLL10 TUBA3E TYK2 TYMSOS UBE2I UBE2Q1 VWC2L WDR25 WNK1 YPEL3 ZCCHC14 ZFP36 ZNF417 ZNF512B ZNF587	21 interacting genes: ACTB CEBPA FHL3 FSD2 FXR1 GIT2 GOLGA2 IFT20 LMO2 MAGEA11 MAGOH NCF4 POLR1C POT1 SMAD3 SMARCD1 SPATA20 STAT3 TAB1 THBS1 YTHDC1
Entrez ID		2275	11151
HPRD ID		09101	05414
Ensembl ID		ENSG00000183386	ENSG00000102879
Uniprot IDs		Q13643 Q96C98	P31146
PDB IDs		1WYH 2CUQ 2EHE
Enriched GO Terms of Interacting Partners?		Protein Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Ventral Spinal Cord Interneuron Differentiation Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Chromatin Binding Positive Regulation Of Biosynthetic Process Regulation Of MiRNA Metabolic Process Transcription Coregulator Binding DNA-binding Transcription Factor Activity Regulation Of Primary Metabolic Process DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Transcription Phosphatase Binding Positive Regulation Of Macromolecule Metabolic Process Cell Population Proliferation Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of MiRNA Transcription Identical Protein Binding SMAD Protein Complex Sequence-specific Double-stranded DNA Binding Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Chromatin Positive Regulation Of MiRNA Metabolic Process Heteromeric SMAD Protein Complex Myelination DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Axon Ensheathment	Positive Regulation Of Biosynthetic Process Brahma Complex NBAF Complex RSC-type Complex NpBAF Complex GBAF Complex Positive Regulation Of Macromolecule Biosynthetic Process Transcription By RNA Polymerase I Chromatin DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Interleukin-6-mediated Signaling Pathway DNA-binding Transcription Factor Binding Osteoblast Development DEAD/H-box RNA Helicase Binding Nuclear Glucocorticoid Receptor Binding Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transforming Growth Factor Beta Production Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Nucleotide-excision Repair Negative Regulation Of Developmental Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Double-strand Break Repair Nucleoplasm Nuclear Matrix SWI/SNF Complex Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Developmental Process Positive Regulation Of Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macrophage Activation Positive Regulation Of Gene Expression Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process BHLH Transcription Factor Binding Positive Regulation Of Extracellular Matrix Organization Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Metabolic Process MRNA Transport RNA Transport Regulation Of MiRNA-mediated Gene Silencing Regulation Of Post-transcriptional Gene Silencing Positive Regulation Of Metabolic Process Regulation Of G0 To G1 Transition Regulation Of Multicellular Organismal Development Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Activation Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B
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