VPS18 and GGA3

Number of citations of the paper that reports this interaction (PubMedID 16996030)
0

Data Source:
BioGRID (enzymatic study)

		VPS18	GGA3
Description		VPS18 core subunit of CORVET and HOPS complexes	golgi associated, gamma adaptin ear containing, ARF binding protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Actin Filament Endosome Membrane Endomembrane System Membrane AP-3 Adaptor Complex Clathrin-coated Vesicle HOPS Complex Cytoplasmic Vesicle Late Endosome Membrane CORVET Complex Presynapse Glutamatergic Synapse	Lysosome Endosome Early Endosome Golgi Apparatus Trans-Golgi Network Endosome Membrane Membrane Early Endosome Membrane Protein-containing Complex Recycling Endosome Recycling Endosome Membrane
	Molecular Function	Actin Binding Protein Binding Zinc Ion Binding Syntaxin Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Small GTPase Binding Phosphatidylinositol Binding Ubiquitin Binding Protein-containing Complex Binding Protein Transporter Activity
	Biological Process	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Autophagy Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Protein Ubiquitination Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Symbiont Entry Into Host Cell Organelle Fusion Regulation Of Synaptic Vesicle Exocytosis	Protein Targeting To Lysosome Intracellular Protein Transport Golgi To Plasma Membrane Transport Protein Transport Vesicle-mediated Transport Protein Catabolic Process Regulation Of Protein Stability Protein Destabilization Endocytic Recycling Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Positive Regulation Of Protein Catabolic Process Protein Localization To Lysosome Negative Regulation Of Amyloid-beta Formation Positive Regulation Of Lysosomal Protein Catabolic Process
Pathways		SARS-CoV-2 modulates autophagy	TBC/RABGAPs MET receptor recycling Amyloid fiber formation
Drugs
Diseases
GWAS		Hemoglobin ( 32888494) Malaria ( 31844061) Refractive error ( 32231278) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		22 interacting genes: AKTIP COPB1 EP300 GGA1 GGA2 GGA3 HOOK1 MON1B PLEKHM1 RAB7A RILP SHANK3 STX1A STX6 STX7 STX8 UBE2D2 UVRAG VPS11 VPS16 VPS33A VPS45	45 interacting genes: ADRA2A ADRA2B AFTPH AP1G1 AP1S2 ARAP3 ARF1 ARF3 CDKN2A CLINT1 CLTC CYTH2 DAZAP2 EGFR ETS1 GGA1 GGA2 GTPBP4 IGF2R LITAF LRP10 M6PR NPM1 P4HA3 PACS1 PLEKHB2 PTGDR PTGDS RABEP1 RNF11 RNF214 RPS27A STAB1 SYNRG TBC1D3 TOLLIP TP53 TRAPPC6A TRIM23 TSG101 UBC UPRT VPS11 VPS18 ZNF497
Entrez ID		57617	23163
HPRD ID		09776	10443
Ensembl ID		ENSG00000104142	ENSG00000125447
Uniprot IDs		Q9P253	A8K6M0 B7Z456 Q9NZ52
PDB IDs			1JPL 1JUQ 1LF8 1P4U 1WR6 1YD8
Enriched GO Terms of Interacting Partners?		Protein Transport Intracellular Protein Localization Vesicle-mediated Transport Intracellular Transport Cellular Localization Establishment Of Localization In Cell Establishment Of Protein Localization Intracellular Protein Transport Endosome Vesicle Organization Vesicle Fusion Organelle Membrane Fusion Vacuolar Transport Lysosomal Transport Organelle Fusion Membrane Fusion Late Endosome Endosome To Lysosome Transport Endosome Membrane Early Endosome HOPS Complex Endosomal Transport Early Endosome To Late Endosome Transport Membrane Organization Lysosome Late Endosome Membrane Membrane Docking Cytoplasmic Vesicle Organelle Localization Vesicle Docking Lysosomal Membrane SNARE Binding Recycling Endosome Organelle Organization Clathrin-coated Vesicle Organelle Localization By Membrane Tethering Chloride Channel Inhibitor Activity Endosome Organization CORVET Complex Phagocytic Vesicle Vacuole Organization SNAP Receptor Activity SNARE Complex Syntaxin Binding Vesicle-mediated Transport To The Plasma Membrane Establishment Of Protein Localization To Plasma Membrane Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Golgi Vesicle Transport Autophagy	Vesicle-mediated Transport Intracellular Protein Transport Cellular Localization Clathrin-coated Vesicle Endosome Establishment Of Localization In Cell Intracellular Transport Protein Transport Establishment Of Protein Localization Endosome Membrane Intracellular Protein Localization Early Endosome Golgi Apparatus AP-1 Adaptor Complex Endocytosis Trans-Golgi Network Membrane Trans-Golgi Network Lysosomal Transport Early Endosome Membrane Perinuclear Region Of Cytoplasm Import Into Cell Vacuolar Transport Autophagy Ubiquitin Protein Ligase Binding Endosome To Lysosome Transport Alpha2-adrenergic Receptor Activity Protein-containing Complex Golgi Membrane Protein Localization To Organelle Clathrin-coated Endocytic Vesicle Membrane Endocytic Vesicle Clathrin-coated Pit Disordered Domain Specific Binding Lysosomal Membrane Late Endosome Endomembrane System Negative Regulation Of Epinephrine Secretion Golgi Vesicle Transport Negative Regulation Of Norepinephrine Secretion Epinephrine Binding Clathrin Coat Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Clathrin Coat Of Trans-Golgi Network Vesicle CORVET Complex Ubiquitin Binding Post-Golgi Vesicle-mediated Transport Vesicle Organization Protein Localization To Ciliary Membrane Regulation Of Uterine Smooth Muscle Contraction Adrenergic Receptor Activity
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