VPS18

Description		VPS18 core subunit of CORVET and HOPS complexes
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Actin Filament Endosome Membrane Endomembrane System Membrane AP-3 Adaptor Complex Clathrin-coated Vesicle HOPS Complex Cytoplasmic Vesicle Late Endosome Membrane CORVET Complex Presynapse Glutamatergic Synapse
	Molecular Function	Actin Binding Protein Binding Zinc Ion Binding Syntaxin Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Autophagy Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Protein Ubiquitination Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Symbiont Entry Into Host Cell Organelle Fusion Regulation Of Synaptic Vesicle Exocytosis
Pathways		SARS-CoV-2 modulates autophagy
Drugs
Diseases
GWAS		Hemoglobin ( 32888494) Malaria ( 31844061) Refractive error ( 32231278) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Novel Interacting Genes		1 novel interacting genes: CLCN3
Interacting Genes		22 interacting genes: AKTIP COPB1 EP300 GGA1 GGA2 GGA3 HOOK1 MON1B PLEKHM1 RAB7A RILP SHANK3 STX1A STX6 STX7 STX8 UBE2D2 UVRAG VPS11 VPS16 VPS33A VPS45
Entrez ID		57617
HPRD ID		09776
Ensembl ID		ENSG00000104142
Uniprot IDs		Q9P253
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Transport Intracellular Protein Localization Vesicle-mediated Transport Intracellular Transport Cellular Localization Establishment Of Localization In Cell Establishment Of Protein Localization Intracellular Protein Transport Endosome Vesicle Organization Vesicle Fusion Organelle Membrane Fusion Vacuolar Transport Lysosomal Transport Organelle Fusion Membrane Fusion Late Endosome Endosome To Lysosome Transport Endosome Membrane Early Endosome HOPS Complex Endosomal Transport Early Endosome To Late Endosome Transport Membrane Organization Lysosome Late Endosome Membrane Membrane Docking Cytoplasmic Vesicle Organelle Localization Vesicle Docking Lysosomal Membrane SNARE Binding Recycling Endosome Organelle Organization Clathrin-coated Vesicle Organelle Localization By Membrane Tethering Chloride Channel Inhibitor Activity Endosome Organization CORVET Complex Phagocytic Vesicle Vacuole Organization SNAP Receptor Activity SNARE Complex Syntaxin Binding Vesicle-mediated Transport To The Plasma Membrane Establishment Of Protein Localization To Plasma Membrane Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Golgi Vesicle Transport Autophagy
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