VPS18 and GGA2

Number of citations of the paper that reports this interaction (PMID 16996030)
12

Data Source:
BioGRID (pull down, affinity chromatography technology)

		VPS18	GGA2
Gene Name		vacuolar protein sorting 18 homolog (S. cerevisiae)	golgi-associated, gamma adaptin ear containing, ARF binding protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Actin Filament HOPS Complex Late Endosome Membrane	Golgi Apparatus Trans-Golgi Network Endosome Membrane Clathrin Adaptor Complex Clathrin-coated Vesicle
	Molecular Function	Actin Binding Protein Binding Syntaxin Binding Protein Binding, Bridging Metal Ion Binding	Protein Binding ADP-ribosylation Factor Binding
	Biological Process	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Endosome Organization Lysosome Organization Regulation Of SNARE Complex Assembly Viral Entry Into Host Cell	Intracellular Protein Transport Vesicle-mediated Transport
Pathways
Drugs
Diseases
GWAS		Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Protein-Protein Interactions		18 interactors: AKTIP COPB1 EP300 GGA1 GGA2 GGA3 HOOK1 MON1B STX1A STX6 STX7 STX8 UBE2D2 UVRAG VPS11 VPS16 VPS33A VPS45	30 interactors: AFTPH APP ARF1 ARF3 ATXN1 BACE1 BACE2 CA8 CCDC91 CLINT1 CLTC GGA1 GGA3 HGS HTT IGF2R LRP3 M6PR PIN1 RAB5A RABEP1 RABGEF1 RNF11 SORL1 SORT1 SPG21 STAB1 SYNRG TRIM23 VPS18
Entrez ID		57617	23062
HPRD ID		09776	09347
Ensembl ID		ENSG00000104142	ENSG00000103365
Uniprot IDs		Q9P253	Q9UJY4
PDB IDs			1MHQ
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Protein Transport Establishment Of Protein Localization Protein Localization Intracellular Transport Establishment Of Localization In Cell Intracellular Protein Transport Cellular Localization Vesicle Fusion Cellular Protein Localization Transport Organelle Fusion Vesicle Organization Membrane Fusion Vesicle Docking Endosomal Transport Early Endosome To Late Endosome Transport Membrane Docking Endosome To Lysosome Transport Endosome Organization Lysosomal Transport Vesicle Docking Involved In Exocytosis Membrane Organization Vacuolar Transport Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Organelle Organization Organelle Localization Viral Entry Into Host Cell Entry Into Host Cell Vesicle Localization Viral Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Protein Localization To Plasma Membrane Histone H2B Acetylation Regulation Of Vacuole Fusion, Non-autophagic Positive Regulation Of Receptor Localization To Synapse Regulation Of DNA-templated Transcription In Response To Stress Lysosome Organization Positive Regulation Of Protein Binding Exocytosis N-terminal Peptidyl-lysine Acetylation Regulation Of Protein Localization Cellular Response To Hypoxia Regulation Of Vesicle-mediated Transport Cellular Response To Decreased Oxygen Levels Interaction With Host Vacuole Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Cellular Response To Oxygen Levels Regulation Of Tubulin Deacetylation	Vesicle-mediated Transport Endocytosis Intracellular Transport Protein Transport Establishment Of Protein Localization Transport Establishment Of Localization In Cell Protein Localization Cellular Localization Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Lysosomal Transport Golgi Vesicle Transport Vacuolar Transport Cellular Protein Localization Endosomal Transport Regulation Of Vesicle-mediated Transport Endosome To Lysosome Transport Cytoplasmic Transport Visual Learning Membrane Organization Visual Behavior Protein Targeting To Lysosome Protein Localization To Lysosome Associative Learning Cellular Copper Ion Homeostasis Membrane Protein Ectodomain Proteolysis Signaling Protein Targeting To Vacuole Copper Ion Homeostasis Cell Communication Negative Regulation Of Signaling Establishment Of Protein Localization To Vacuole Learning Transition Metal Ion Homeostasis Membrane Protein Proteolysis Regulation Of Exocytosis Retrograde Vesicle-mediated Transport, Golgi To ER Regulation Of Synaptic Plasticity Regulation Of Protein Catabolic Process Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Phosphorylation Neural Plate Formation Negative Regulation Of Kit Signaling Pathway Positive Regulation Of Early Endosome To Recycling Endosome Transport Negative Regulation Of Tau-protein Kinase Activity Negative Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Choline O-acetyltransferase Activity
Tagcloud ?			addressed adulthood allele attributable byg c57bl c57bl6 disrupted ear establishes gga1 gga3 ggas harbors homozygous hypomorphic insertional knockout lethality mutagenesis neonatal ola129sv placement redundancy ribosylation runted survive tigm true
Tagcloud (Difference) ?			addressed adulthood allele attributable byg c57bl c57bl6 disrupted ear establishes gga1 gga3 ggas harbors homozygous hypomorphic insertional knockout lethality mutagenesis neonatal ola129sv placement redundancy ribosylation runted survive tigm true
Tagcloud (Intersection) ?