VPS18 and UVRAG

Number of citations of the paper that reports this interaction (PubMedID 18552835)
46

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		VPS18	UVRAG
Description		VPS18 core subunit of CORVET and HOPS complexes	UV radiation resistance associated
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Actin Filament Endosome Membrane Endomembrane System Membrane AP-3 Adaptor Complex Clathrin-coated Vesicle HOPS Complex Cytoplasmic Vesicle Late Endosome Membrane CORVET Complex Presynapse Glutamatergic Synapse	Lytic Vacuole Autophagosome Membrane Chromosome, Centromeric Region Chromosome Cytoplasm Lysosome Endosome Early Endosome Late Endosome Autophagosome Endoplasmic Reticulum Centrosome Midbody Cytoplasmic Vesicle Protein-containing Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Phosphatidylinositol 3-kinase Complex, Class III Phagocytic Vesicle DNA-dependent Protein Kinase Complex
	Molecular Function	Actin Binding Protein Binding Zinc Ion Binding Syntaxin Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	SNARE Binding Protein Binding SH3 Domain Binding
	Biological Process	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Autophagy Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Protein Ubiquitination Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Symbiont Entry Into Host Cell Organelle Fusion Regulation Of Synaptic Vesicle Exocytosis	DNA Repair Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Autophagy DNA Damage Response Spindle Organization Chromosome Segregation Centrosome Cycle Regulation Of Autophagy Vesicle-mediated Transport Regulation Of Cytokinesis Receptor Catabolic Process SNARE Complex Assembly Phosphatidylinositol-3-phosphate Biosynthetic Process Protein-containing Complex Organization Symbiont Entry Into Host Cell Maintenance Of Golgi Location Regulation Of Protein Serine/threonine Kinase Activity Multivesicular Body Sorting Pathway Autophagosome Maturation Double-strand Break Repair Via Classical Nonhomologous End Joining Positive Regulation Of Autophagosome Maturation
Pathways		SARS-CoV-2 modulates autophagy	Macroautophagy Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex SARS-CoV-2 modulates autophagy
Drugs
Diseases
GWAS		Hemoglobin ( 32888494) Malaria ( 31844061) Refractive error ( 32231278) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Asthma ( 31619474) HDL cholesterol ( 30275531) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Mean spheric corpuscular volume ( 32888494) Stroke ( 32693751) Thumb osteoarthritis severity (hand Klsum) ( 33055079)
Interacting Genes		22 interacting genes: AKTIP COPB1 EP300 GGA1 GGA2 GGA3 HOOK1 MON1B PLEKHM1 RAB7A RILP SHANK3 STX1A STX6 STX7 STX8 UBE2D2 UVRAG VPS11 VPS16 VPS33A VPS45	10 interacting genes: CSNK1A1 ITCH MTOR NEDD4 VPS11 VPS16 VPS18 VPS33B YAP1 ZRANB1
Entrez ID		57617	7405
HPRD ID		09776	03929
Ensembl ID		ENSG00000104142	ENSG00000198382
Uniprot IDs		Q9P253	Q9P2Y5
PDB IDs			7BL1
Enriched GO Terms of Interacting Partners?		Protein Transport Intracellular Protein Localization Vesicle-mediated Transport Intracellular Transport Cellular Localization Establishment Of Localization In Cell Establishment Of Protein Localization Intracellular Protein Transport Endosome Vesicle Organization Vesicle Fusion Organelle Membrane Fusion Vacuolar Transport Lysosomal Transport Organelle Fusion Membrane Fusion Late Endosome Endosome To Lysosome Transport Endosome Membrane Early Endosome HOPS Complex Endosomal Transport Early Endosome To Late Endosome Transport Membrane Organization Lysosome Late Endosome Membrane Membrane Docking Cytoplasmic Vesicle Organelle Localization Vesicle Docking Lysosomal Membrane SNARE Binding Recycling Endosome Organelle Organization Clathrin-coated Vesicle Organelle Localization By Membrane Tethering Chloride Channel Inhibitor Activity Endosome Organization CORVET Complex Phagocytic Vesicle Vacuole Organization SNAP Receptor Activity SNARE Complex Syntaxin Binding Vesicle-mediated Transport To The Plasma Membrane Establishment Of Protein Localization To Plasma Membrane Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Golgi Vesicle Transport Autophagy	CORVET Complex HOPS Complex Vacuole Organization Vesicle Tethering Complex Lysosomal Transport Vacuolar Transport Endosome To Lysosome Transport Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Positive Regulation Of Protein Catabolic Process Catabolic Process Clathrin-coated Vesicle Vesicle Fusion Intracellular Protein Transport Organelle Membrane Fusion Endosome Membrane Protein Modification Process Early Endosome Organelle Fusion Regulation Of Protein Catabolic Process Lysosomal Membrane Late Endosome Membrane Late Endosome Membrane Fusion Regulation Of Protein-containing Complex Assembly Protein Metabolic Process Post-translational Protein Modification Cytoplasmic Vesicle Negative Regulation Of Signal Transduction Lysosome Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Autophagosome Endosome Organization Regulation Of Cellular Component Organization Protein Transport Protein Ubiquitination Autophagosome Assembly Autophagy Autophagosome Organization Vesicle-mediated Transport Vesicle Organization Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Proteolysis Involved In Protein Catabolic Process Proteolysis Intracellular Transport Protein Modification By Small Protein Conjugation
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