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BEGAIN and HGS
Number of citations of the paper that reports this interaction (PMID
16189514
)
699
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
BEGAIN
HGS
Gene Name
brain-enriched guanylate kinase-associated
hepatocyte growth factor-regulated tyrosine kinase substrate
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Membrane
Dendrite
Neuronal Cell Body
Cytoplasm
Endosome
Early Endosome
Cytosol
Secretory Granule
Early Endosome Membrane
Multivesicular Body Membrane
Intracellular Membrane-bounded Organelle
Extracellular Vesicular Exosome
Molecular Function
Protein Binding
Protein Binding
Protein Domain Specific Binding
Metal Ion Binding
Biological Process
Protein Targeting To Lysosome
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Cell Proliferation
Endosome To Lysosome Transport
Membrane Invagination
Positive Regulation Of Gene Expression
Endosomal Transport
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Protein Catabolic Process
Negative Regulation Of JAK-STAT Cascade
Membrane Organization
Protein Localization To Membrane
Positive Regulation Of Exosomal Secretion
Pathways
Signaling by EGFR
EGFR downregulation
Endosomal Sorting Complex Required For Transport (ESCRT)
Signaling by EGFR in Cancer
Signaling by Ligand-Responsive EGFR Variants in Cancer
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by EGFRvIII in Cancer
Drugs
Diseases
GWAS
Menarche (age at onset) (
21102462
)
Eye color traits (
20463881
)
Protein-Protein Interactions
23 interactors:
ABLIM1
APP
BAHD1
CATSPER1
DEF6
DLG1
DLG4
DTNB
ENKD1
FAM107A
GFI1B
HGS
HID1
KIAA0408
QSOX1
RBL1
RIBC2
TRIM27
USP2
ZFP64
ZNF250
ZNF417
ZNF774
138 interactors:
ABI2
ACLY
AHCYL1
APC
APLP2
APP
ARFIP2
ARL6IP1
ATP1A1
ATP2A2
ATXN1L
BCAS2
BEGAIN
BRINP3
BSG
CASK
CBS
CCDC103
CCDC114
CCDC33
CEP55
CEP57L1
CLTC
CRMP1
CSTF2
CSTF2T
CTTNBP2NL
DAZAP2
DCTN2
DECR1
DGCR6
DLG4
EGFR
EHMT2
EPS15
ESRRG
EXOC7
EXOC8
GFAP
GFI1B
GGA2
GKAP1
HAP1
HNRNPDL
HSPA8
IL2RB
IL4R
ILKAP
ING5
INTS4
JAKMIP2
KRT15
KRT18
KRT19
KRT31
KRT38
KRT40
KRT6A
LDOC1
LINC00265
LITAF
LURAP1
LYST
MAGEB4
MAP3K10
MAP3K7
MAPK1IP1L
MARK4
MAT2A
MED7
MEST
MET
MIF4GD
MKNK1
MRFAP1L1
MTHFD1L
NDC80
NEDD4
NEDD4L
NF2
NMI
NPAS2
NUP54
OSBPL5
P4HA3
PAK1
PEF1
PELP1
PFKM
PIK3R1
PITX1
PLD3
POGZ
PPP1R16A
PPP1R7
PTCD3
RHOBTB3
RPS3A
RSU1
SCAMP3
SCRN1
SF3B3
SMAD2
SMAD3
SMAD5
SNAP25
SNX1
SNX5
SNX7
STAM
STAM2
STXBP1
SUMO1
SUN2
TADA2A
TIMMDC1
TJP2
TMCC2
TOM1L1
TRAK1
TRAP1
TSG101
TUBB
TUBB2A
UBA1
UBA52
UBB
UBC
UBE2I
UBE4B
UBQLN1
UBQLN4
USHBP1
VMP1
VPS37A
VPS37C
VPS37D
ZNF302
Entrez ID
57596
9146
HPRD ID
06459
05085
Ensembl ID
ENSG00000183092
ENSG00000185359
Uniprot IDs
Q9BUH8
O14964
PDB IDs
2D3G
3F1I
3OBQ
3ZYQ
4AVX
Enriched GO Terms of Interacting Partners
?
Receptor Localization To Synapse
Regulation Of Metabolic Process
Protein Localization To Synapse
Regulation Of Gene Expression
Cell Recognition
Regulation Of Transcription, DNA-templated
Regulation Of Cellular Process
Cortical Actin Cytoskeleton Organization
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Establishment Or Maintenance Of Apical/basal Cell Polarity
Axon Guidance
Cortical Cytoskeleton Organization
Regulation Of RNA Metabolic Process
Transcription, DNA-templated
Regulation Of Ion Transmembrane Transport
Nucleobase-containing Compound Metabolic Process
RNA Biosynthetic Process
Heterocycle Metabolic Process
RNA Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Receptor Clustering
Axonogenesis
Response To Brefeldin A
Locomotory Behavior
Gene Expression
Negative Regulation Of Cellular Metabolic Process
Nucleotide Phosphorylation
Axon Development
Cell Morphogenesis Involved In Neuron Differentiation
Cell-cell Recognition
Chemotaxis
Regulation Of Membrane Potential
Regulation Of Ion Transport
Negative Regulation Of Transcription, DNA-templated
Neuron Projection Morphogenesis
Negative Regulation Of Interleukin-2 Secretion
Synaptic Growth At Neuromuscular Junction
Negative Regulation Of Gene Expression, Epigenetic
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Nucleic Acid-templated Transcription
Nitrogen Compound Metabolic Process
Neuromuscular Process Controlling Balance
Synapse Assembly
Negative Regulation Of RNA Biosynthetic Process
Regulation Of ERBB Signaling Pathway
Collateral Sprouting In Absence Of Injury
Cell Morphogenesis Involved In Differentiation
Establishment Of Localization In Cell
Cellular Localization
Viral Protein Processing
Protein Localization
Intracellular Transport
Membrane Organization
Endosomal Transport
Establishment Of Protein Localization
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Protein Transport
Regulation Of ERBB Signaling Pathway
Virion Assembly
Intracellular Transport Of Virus
Viral Process
Cellular Protein Localization
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of ERBB Signaling Pathway
Vesicle-mediated Transport
Viral Life Cycle
Cell Cycle Process
Organelle Organization
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Mitotic Cell Cycle
Mitotic Cell Cycle Process
Transport
Post-Golgi Vesicle-mediated Transport
Transforming Growth Factor Beta Receptor Signaling Pathway
Cellular Metabolic Process
Gene Expression
Cell Cycle
Vesicle Organization
Secretion By Cell
Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
ERBB Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Intracellular Protein Transport
Transcription Initiation From RNA Polymerase II Promoter
Cellular Process
Cellular Response To Transforming Growth Factor Beta Stimulus
Posttranscriptional Regulation Of Gene Expression
Secretion
Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Transcription From RNA Polymerase II Promoter
Response To Transforming Growth Factor Beta
Regulation Of Protein Catabolic Process
JNK Cascade
Response To Organic Substance
Tagcloud
?
adjustments
associates
confounders
continued
cubic
cv
geriatric
gnri
handgrip
hemodialysis
hospitalization
hospitalizations
malnutrition
mhd
mis
nutritional
observational
outpatients
qol
scales
sf
sf36
spline
sua
tertile
trends
upcoming
uric
y
Tagcloud (Difference)
?
adjustments
associates
confounders
continued
cubic
cv
geriatric
gnri
handgrip
hemodialysis
hospitalization
hospitalizations
malnutrition
mhd
mis
nutritional
observational
outpatients
qol
scales
sf
sf36
spline
sua
tertile
trends
upcoming
uric
y
Tagcloud (Intersection)
?