BEGAIN and USP2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		BEGAIN	USP2
Gene Name		brain-enriched guanylate kinase-associated	ubiquitin specific peptidase 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Membrane Dendrite Neuronal Cell Body	Nucleus Cytoplasm Centrosome Cell Cortex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Cyclin Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding
	Biological Process		Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Muscle Organ Development Protein Deubiquitination Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Locomotor Rhythm Positive Regulation Of Mitotic Cell Cycle Circadian Behavior Negative Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Skeletal Muscle Tissue Development Protein Stabilization Regulation Of Proteasomal Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS		Menarche (age at onset) ( 21102462)	Urate levels ( 23263486)
Protein-Protein Interactions		23 interactors: ABLIM1 APP BAHD1 CATSPER1 DEF6 DLG1 DLG4 DTNB ENKD1 FAM107A GFI1B HGS HID1 KIAA0408 QSOX1 RBL1 RIBC2 TRIM27 USP2 ZFP64 ZNF250 ZNF417 ZNF774	67 interactors: APP AURKA BAP1 BEGAIN BEND5 BRCA1 CBLC CCDC136 CCDC36 CCDC57 CCDC85B CCND1 CRY1 DTX3 ERBB2 GOLGA2 HOMER3 HOOK1 HOOK2 IKBKG KIFC3 KRT15 KRT40 LHX4 LNX2 LONRF1 LRSAM1 LZTS2 MAP3K2 MDM2 MNAT1 MTUS2 NDEL1 NEFL NFKB2 PCGF6 PCNA PLA2G2A PNMA1 RAD18 RBCK1 RIPK1 RNF125 RNF126 RNF144B RNF166 TRAF2 TRAF6 TRAIP TRIM21 TRIM23 TRIM27 TRIM34 TRIM35 TRIM39 TRIM46 TRIM5 TRIM54 TRIM63 TRIM74 TRIM8 TRIM9 UBC UBE2S UBOX5 USP21 VPS52
Entrez ID		57596	9099
HPRD ID		06459	05287
Ensembl ID		ENSG00000183092	ENSG00000036672
Uniprot IDs		Q9BUH8	E9PPM2 O75604
PDB IDs			2HD5 2IBI 3NHE 3V6C 3V6E
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Regulation Of Metabolic Process Protein Localization To Synapse Regulation Of Gene Expression Cell Recognition Regulation Of Transcription, DNA-templated Regulation Of Cellular Process Cortical Actin Cytoskeleton Organization Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Establishment Or Maintenance Of Apical/basal Cell Polarity Axon Guidance Cortical Cytoskeleton Organization Regulation Of RNA Metabolic Process Transcription, DNA-templated Regulation Of Ion Transmembrane Transport Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Heterocycle Metabolic Process RNA Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Receptor Clustering Axonogenesis Response To Brefeldin A Locomotory Behavior Gene Expression Negative Regulation Of Cellular Metabolic Process Nucleotide Phosphorylation Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cell-cell Recognition Chemotaxis Regulation Of Membrane Potential Regulation Of Ion Transport Negative Regulation Of Transcription, DNA-templated Neuron Projection Morphogenesis Negative Regulation Of Interleukin-2 Secretion Synaptic Growth At Neuromuscular Junction Negative Regulation Of Gene Expression, Epigenetic Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Nitrogen Compound Metabolic Process Neuromuscular Process Controlling Balance Synapse Assembly Negative Regulation Of RNA Biosynthetic Process Regulation Of ERBB Signaling Pathway Collateral Sprouting In Absence Of Injury Cell Morphogenesis Involved In Differentiation	Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Protein Polyubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Protein Metabolic Process Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Innate Immune Response Negative Regulation Of Viral Release From Host Cell Protein K63-linked Ubiquitination Protein Metabolic Process Cellular Protein Catabolic Process Defense Response Protein Complex Assembly Regulation Of Viral Release From Host Cell Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Stress Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Protein Trimerization Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor 4 Signaling Pathway Protein Autoubiquitination Activation Of Innate Immune Response Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Immune Response-regulating Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Type I Interferon Production Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Kinase Activity Toll-like Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Regulation Of MAP Kinase Activity Regulation Of Cytokine Production Catabolic Process Response To Cytokine Positive Regulation Of MAP Kinase Activity
Tagcloud ?			accessory alpha2delta beta2 biotinylation cav cav1 channels counteracted counterpart currents de developmentally gated hek inserted ligases nedd4 paramount precipitated recordings remarkably tsa ubiquitylated ubiquitylates ubiquitylating ubiquitylation usps voltage
Tagcloud (Difference) ?			accessory alpha2delta beta2 biotinylation cav cav1 channels counteracted counterpart currents de developmentally gated hek inserted ligases nedd4 paramount precipitated recordings remarkably tsa ubiquitylated ubiquitylates ubiquitylating ubiquitylation usps voltage
Tagcloud (Intersection) ?