BEGAIN and DEF6

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
HPRD (two hybrid)

		BEGAIN	DEF6
Description		brain enriched guanylate kinase associated	DEF6 guanine nucleotide exchange factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Membrane Synapse Postsynapse	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Filopodium Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Evoked Excitatory Postsynaptic Potential	Regulation Of Small GTPase Mediated Signal Transduction Vesicle-mediated Transport To The Plasma Membrane
Pathways		Neurexins and neuroligins	RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle
Drugs
Diseases
GWAS		Chronotype ( 30696823) Menarche (age at onset) ( 21102462) Metabolite levels ( 23823483) Refractive error ( 32231278)	Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Height ( 18391951 33713608) Hip circumference adjusted for BMI ( 34021172) Lymphocyte count ( 32888494) Neutrophil count ( 32888494) Systemic lupus erythematosus ( 28714469 33493351) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)
Interacting Genes		47 interacting genes: ABLIM1 APP AQP1 ATPAF2 BAHD1 BMP7 CATSPER1 CDC23 DDX6 DEF6 DLG1 DLG4 DTNB ENKD1 FAM107A FAM161A FAM90A1 GEM GFI1B GMCL1 GUCD1 HDAC4 HGS HID1 KIAA0408 KIFC3 LENG1 MAB21L3 PRPF18 PRR35 QSOX1 RASAL3 RBL1 RIBC2 SAXO1 TRAF4 TRIM27 USP2 ZFP64 ZNF250 ZNF319 ZNF417 ZNF572 ZNF587 ZNF648 ZNF774 ZNF835	32 interacting genes: APP ARHGAP22 BEGAIN CCDC88B CDC42 CDC42EP1 EIF4ENIF1 GOLGA6A GOLGA6L9 HOMEZ INCA1 INTS2 KIAA1328 KRT31 L3MBTL3 LCK PBXIP1 PLSCR1 PSMA1 PTK2 RAC1 RAC2 RAPGEF4 RASAL3 REL RHOA SAP18 SLU7 TCF4 TEPSIN ZAP70 ZNF688
Entrez ID		57596	50619
HPRD ID		06459	10869
Ensembl ID		ENSG00000183092	ENSG00000023892
Uniprot IDs		A0A1B0GTT1 G3V3A2 G3V3R5 Q9BUH8	Q9H4E7
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Zinc Ion Binding NMDA Selective Glutamate Receptor Signaling Pathway Protein Binding Regulation Of Mitotic Cell Cycle Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process	Positive Regulation Of Immune System Process Cytosol Positive Regulation Of Leukocyte Migration Regulation Of Cell Adhesion Beta Selection Small GTPase-mediated Signal Transduction Focal Adhesion Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Activation Intracellular Signaling Cassette Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Leukocyte Proliferation Regulation Of Neuron Differentiation Positive Regulation Of Leukocyte Chemotaxis Supramolecular Fiber Organization Positive Regulation Of Cell Adhesion Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Lamellipodium Organization Erythrocyte Enucleation Lymphocyte Aggregation Regulation Of Cell-substrate Adhesion Regulation Of Lamellipodium Assembly Regulation Of Leukocyte Migration Postsynapse Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Cell Activation Regulation Of T Cell Activation Regulation Of Immune System Process Membrane Invagination Cytoplasm Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Stress Fiber Assembly Positive Regulation Of T Cell Activation Non-canonical Wnt Signaling Pathway Regulation Of Lamellipodium Organization Peptidyl-tyrosine Phosphorylation CD4 Receptor Binding Regulation Of Cell Shape Regulation Of Granulocyte Chemotaxis Regulation Of Postsynapse Organization Positive Regulation Of Chemotaxis Thioesterase Binding Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Cell-cell Adhesion Protein Kinase Binding Leukocyte Aggregation Regulation Of Substrate Adhesion-dependent Cell Spreading
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