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SIN3A and IKZF4
Number of citations of the paper that reports this interaction (PMID
12015313
)
17
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
SIN3A
IKZF4
Gene Name
SIN3 transcription regulator family member A
IKAROS family zinc finger 4 (Eos)
Image
Gene Ontology Annotations
Cellular Component
Kinetochore
Nucleus
Nucleoplasm
Transcription Factor Complex
Nucleolus
Cytoplasm
Sin3 Complex
Transcriptional Repressor Complex
Intercellular Bridge
Nucleus
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Activating Transcription Factor Binding
RNA Polymerase II Repressing Transcription Factor Binding
RNA Polymerase II Transcription Corepressor Activity
Chromatin Binding
Sequence-specific DNA Binding Transcription Factor Activity
Histone Deacetylase Activity
Protein Binding
Protein Complex Binding
Protein Deacetylase Activity
Sequence-specific DNA Binding Transcription Factor Activity
Protein Homodimerization Activity
BHLH Transcription Factor Binding
Sequence-specific DNA Binding
Metal Ion Binding
Protein Heterodimerization Activity
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
In Utero Embryonic Development
Activation Of Innate Immune Response
Positive Regulation Of Defense Response To Virus By Host
Hematopoietic Progenitor Cell Differentiation
DNA Replication
Transcription, DNA-templated
Protein Deacetylation
Aging
Blood Coagulation
Response To Organonitrogen Compound
Gene Expression
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Histone Deacetylation
Positive Regulation Of Chromatin Silencing
Cellular Protein Localization
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Negative Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Rhythmic Process
Response To Methylglyoxal
Cellular Response To Glucose Stimulus
Negative Regulation Of Protein Localization To Nucleus
Negative Regulation Of Histone H3-K27 Acetylation
Negative Regulation Of Transcription Regulatory Region DNA Binding
Transcription, DNA-templated
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
NoRC negatively regulates rRNA expression
Fatty acid, triacylglycerol, and ketone body metabolism
Metabolism of lipids and lipoproteins
Epigenetic regulation of gene expression
Negative epigenetic regulation of rRNA expression
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS
Height (
20189936
)
Sudden cardiac arrest (
21658281
)
Alopecia areata (
20596022
)
Asthma (
21804548
)
Type 1 diabetes (
18198356
)
Type 1 diabetes autoantibodies (
21829393
)
Vitiligo (
22561518
)
Protein-Protein Interactions
90 interactors:
ARID4A
ARID4B
BCL6
BCL6B
BHLHE40
BRMS1
BRMS1L
CBFA2T2
COPS2
CTBP1
CTCF
CUL4B
DACH1
DDB1
DDX20
DHX30
ETV6
HBP1
HCFC1
HDAC1
HDAC2
HDAC7
HDAC9
HEY2
HIST3H3
HTT
IKZF1
IKZF4
ING1
IRF5
KLF10
KLF11
KLF13
KLF16
KLF9
LINC00152
LRCH4
MAD1L1
MBD2
MBD4
MECP2
MEN1
MNT
MORF4L2
MXD1
MXD3
MXD4
MXI1
MYB
NCOR2
NFKB1
NFKB2
NR2E3
OGT
PA2G4
PHB
PHF12
PML
PRMT5
PTMA
RBBP4
RBBP7
RBP1
RBPJ
REL
RELA
RELB
RLIM
RUNX1T1
SAP18
SAP30
SETDB1
SFPQ
SKI
SMAD3
SMARCA4
SMARCC1
SMARCE1
SNW1
SPI1
STAT3
SYT1
TAL1
TFCP2
TGIF1
THAP11
TOPORS
TP53
TRIM28
ZBTB16
12 interactors:
CHD4
FHL2
FOXP3
HDAC2
IKZF1
IKZF2
IKZF3
IKZF5
NFKBIA
NRG1
SIN3A
SIN3B
Entrez ID
25942
64375
HPRD ID
09690
05874
Ensembl ID
ENSG00000169375
ENSG00000123411
Uniprot IDs
Q96ST3
G5E9S4
Q9H2S9
PDB IDs
1PO4
2MA7
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Transcription, DNA-templated
RNA Biosynthetic Process
RNA Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Gene Expression
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Macromolecule Biosynthetic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
Biosynthetic Process
Regulation Of Metabolic Process
Transcription From RNA Polymerase II Promoter
Chromatin Organization
Chromatin Modification
Chromosome Organization
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Metabolic Process
Regulation Of Cellular Process
Histone Modification
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Cell Proliferation
Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Metabolic Process
Regulation Of Cell Proliferation
Negative Regulation Of Gene Expression, Epigenetic
Organelle Organization
Regulation Of Cell Differentiation
Regulation Of Chromosome Organization
Regulation Of Histone Modification
Cell Differentiation
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
RNA Metabolic Process
Chromatin Modification
Gene Expression
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Cellular Macromolecule Biosynthetic Process
Negative Regulation Of RNA Biosynthetic Process
Macromolecule Biosynthetic Process
Chromatin Organization
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Regulation Of Metabolic Process
Negative Regulation Of Biosynthetic Process
Cardiac Muscle Tissue Development
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Histone Deacetylation
Nucleobase-containing Compound Metabolic Process
Protein Deacetylation
Positive Regulation Of Cellular Biosynthetic Process
Chromosome Organization
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Striated Muscle Tissue Development
Muscle Tissue Development
Regulation Of Immune System Process
Cardiac Muscle Cell Differentiation
Nitrogen Compound Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Cardiocyte Differentiation
Regulation Of Apoptotic Process
Regulation Of Cell Death
Negative Regulation Of Histone Acetylation
Negative Regulation Of Apoptotic Process
Positive Regulation Of Metabolic Process
Tagcloud
?
ablated
bcl6
conducive
cor
corepressors
deacteylases
erbaalpha
erbbeta
interactiondomains
laz3
locks
mad
mxi
physicalassociation
rev
rid
rids
rip13a
rip13delta1
rpd3
rvr
sin3b
tafii32
tafii70
tafs
terminalrepression
tfiib
zip
Tagcloud (Difference)
?
ablated
bcl6
conducive
cor
corepressors
deacteylases
erbaalpha
erbbeta
interactiondomains
laz3
locks
mad
mxi
physicalassociation
rev
rid
rids
rip13a
rip13delta1
rpd3
rvr
sin3b
tafii32
tafii70
tafs
terminalrepression
tfiib
zip
Tagcloud (Intersection)
?