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SIN3A and COPS2
Number of citations of the paper that reports this interaction (PMID
15173382
)
7
Data Source:
BioGRID
(two hybrid)
SIN3A
COPS2
Gene Name
SIN3 transcription regulator family member A
COP9 signalosome subunit 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Kinetochore
Nucleus
Nucleoplasm
Transcription Factor Complex
Nucleolus
Cytoplasm
Sin3 Complex
Transcriptional Repressor Complex
Intercellular Bridge
Cytoplasm
COP9 Signalosome
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Activating Transcription Factor Binding
RNA Polymerase II Repressing Transcription Factor Binding
RNA Polymerase II Transcription Corepressor Activity
Chromatin Binding
Sequence-specific DNA Binding Transcription Factor Activity
Histone Deacetylase Activity
Protein Binding
Protein Complex Binding
Protein Deacetylase Activity
Transcription Corepressor Activity
Signal Transducer Activity
Protein Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
In Utero Embryonic Development
Activation Of Innate Immune Response
Positive Regulation Of Defense Response To Virus By Host
Hematopoietic Progenitor Cell Differentiation
DNA Replication
Transcription, DNA-templated
Protein Deacetylation
Aging
Blood Coagulation
Response To Organonitrogen Compound
Gene Expression
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Histone Deacetylation
Positive Regulation Of Chromatin Silencing
Cellular Protein Localization
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Negative Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Rhythmic Process
Response To Methylglyoxal
Cellular Response To Glucose Stimulus
Negative Regulation Of Protein Localization To Nucleus
Negative Regulation Of Histone H3-K27 Acetylation
Negative Regulation Of Transcription Regulatory Region DNA Binding
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Transcription From RNA Polymerase II Promoter
Signal Transduction
Cell Proliferation
Cullin Deneddylation
Neuron Differentiation
Skeletal Muscle Cell Differentiation
Pathways
NoRC negatively regulates rRNA expression
Fatty acid, triacylglycerol, and ketone body metabolism
Metabolism of lipids and lipoproteins
Epigenetic regulation of gene expression
Negative epigenetic regulation of rRNA expression
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS
Height (
20189936
)
Sudden cardiac arrest (
21658281
)
Protein-Protein Interactions
90 interactors:
ARID4A
ARID4B
BCL6
BCL6B
BHLHE40
BRMS1
BRMS1L
CBFA2T2
COPS2
CTBP1
CTCF
CUL4B
DACH1
DDB1
DDX20
DHX30
ETV6
HBP1
HCFC1
HDAC1
HDAC2
HDAC7
HDAC9
HEY2
HIST3H3
HTT
IKZF1
IKZF4
ING1
IRF5
KLF10
KLF11
KLF13
KLF16
KLF9
LINC00152
LRCH4
MAD1L1
MBD2
MBD4
MECP2
MEN1
MNT
MORF4L2
MXD1
MXD3
MXD4
MXI1
MYB
NCOR2
NFKB1
NFKB2
NR2E3
OGT
PA2G4
PHB
PHF12
PML
PRMT5
PTMA
RBBP4
RBBP7
RBP1
RBPJ
REL
RELA
RELB
RLIM
RUNX1T1
SAP18
SAP30
SETDB1
SFPQ
SKI
SMAD3
SMARCA4
SMARCC1
SMARCE1
SNW1
SPI1
STAT3
SYT1
TAL1
TFCP2
TGIF1
THAP11
TOPORS
TP53
TRIM28
ZBTB16
39 interactors:
COPS3
COPS4
COPS5
COPS6
COPS7A
COPS8
CSNK2A1
CSNK2B
CUL1
CUL4A
CUL5
DDB1
EP300
GFER
GPS1
HIST1H3A
HIST1H4A
ING1
ING2
IP6K1
IRF8
JUN
MAP3K10
MAPK8
NCOR1
NIF3L1
NR0B1
NR2F1
PRKD1
PSMD4
RARA
RXRA
SENP8
SIN3A
SIN3B
THRA
THRB
TP53
VDR
Entrez ID
25942
9318
HPRD ID
09690
05146
Ensembl ID
ENSG00000169375
ENSG00000166200
Uniprot IDs
Q96ST3
P61201
Q59EL2
PDB IDs
1PO4
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Transcription, DNA-templated
RNA Biosynthetic Process
RNA Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Gene Expression
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Macromolecule Biosynthetic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
Biosynthetic Process
Regulation Of Metabolic Process
Transcription From RNA Polymerase II Promoter
Chromatin Organization
Chromatin Modification
Chromosome Organization
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Metabolic Process
Regulation Of Cellular Process
Histone Modification
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Cell Proliferation
Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Metabolic Process
Regulation Of Cell Proliferation
Negative Regulation Of Gene Expression, Epigenetic
Organelle Organization
Regulation Of Cell Differentiation
Regulation Of Chromosome Organization
Regulation Of Histone Modification
Cell Differentiation
Protein Deneddylation
Cullin Deneddylation
Negative Regulation Of Transcription, DNA-templated
Cellular Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Metabolic Process
Protein Modification By Small Protein Removal
Transcription From RNA Polymerase II Promoter
Cellular Protein Modification Process
Hormone-mediated Signaling Pathway
Positive Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Steroid Hormone Mediated Signaling Pathway
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Cellular Protein Metabolic Process
Signal Transduction
DNA-templated Transcription, Initiation
Regulation Of RNA Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Metabolic Process
Negative Regulation Of Cell Proliferation
Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Response To Organic Substance
Signaling
Cellular Response To Steroid Hormone Stimulus
Regulation Of Protein Metabolic Process
Regulation Of Cell Cycle
Regulation Of Protein Deacetylation
Cellular Response To Lipid
Metabolic Process
Cell Communication
Intracellular Receptor Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Regulation Of Gene Expression
Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of Cell Death
Gene Expression
Tagcloud
?
ablated
bcl6
conducive
cor
corepressors
deacteylases
erbaalpha
erbbeta
interactiondomains
laz3
locks
mad
mxi
physicalassociation
rev
rid
rids
rip13a
rip13delta1
rpd3
rvr
sin3b
tafii32
tafii70
tafs
terminalrepression
tfiib
zip
Tagcloud (Difference)
?
ablated
bcl6
conducive
cor
corepressors
deacteylases
erbaalpha
erbbeta
interactiondomains
laz3
locks
mad
mxi
physicalassociation
rev
rid
rids
rip13a
rip13delta1
rpd3
rvr
sin3b
tafii32
tafii70
tafs
terminalrepression
tfiib
zip
Tagcloud (Intersection)
?