SIN3A and RELA

Number of citations of the paper that reports this interaction (PubMedID 17962807)
46

Data Source:
HPRD (in vivo)

		SIN3A	RELA
Description		SIN3 transcription regulator family member A	RELA proto-oncogene, NF-kB subunit
Image		No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Kinetochore Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Nucleolus Transcription Repressor Complex Protein-containing Complex Sin3-type Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Cytosol Protein-containing Complex NF-kappaB P50/p65 Complex Synapse NF-kappaB Complex Glutamatergic Synapse
	Molecular Function	DNA Binding Chromatin Binding Transcription Corepressor Activity RNA Binding Protein Binding Protein-containing Complex Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Protein Kinase Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding Peptide Binding Phosphate Ion Binding Identical Protein Binding Protein Homodimerization Activity Actinin Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein-containing Complex Binding NF-kappaB Binding Ankyrin Repeat Binding General Transcription Initiation Factor Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Hematopoietic Progenitor Cell Differentiation DNA Replication Regulation Of DNA-templated Transcription Intracellular Protein Localization Regulation Of Hormone Levels Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cerebral Cortex Neuron Differentiation Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Axon Extension Heterochromatin Formation Negative Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Differentiation Negative Regulation Of DNA-templated Transcription Rhythmic Process Response To Methylglyoxal Type I Interferon-mediated Signaling Pathway Cellular Response To Glucose Stimulus Cellular Response To Tert-butyl Hydroperoxide Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Cellular Response To Dopamine	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cytokine Production Liver Development Hair Follicle Development Defense Response To Tumor Cell Response To Ischemia Chromatin Organization DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Defense Response Inflammatory Response Cellular Defense Response Neuropeptide Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Bacterium Animal Organ Morphogenesis Response To UV-B Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Positive Regulation Of Schwann Cell Differentiation Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Signal Transduction Involved In Regulation Of Gene Expression Protein Catabolic Process Response To Muramyl Dipeptide Response To Lipopolysaccharide Response To Progesterone Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Response To Insulin Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Protein Sumoylation Response To Cobalamin Response To Cytokine Toll-like Receptor 4 Signaling Pathway Intracellular Signal Transduction Cellular Response To Hepatocyte Growth Factor Stimulus Response To Muscle Stretch Non-canonical NF-kappaB Signal Transduction Vascular Endothelial Growth Factor Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Prolactin Signaling Pathway Negative Regulation Of Protein Catabolic Process Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Amino Acid Response To Morphine Innate Immune Response Response To Ethanol Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Inflammatory Response Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Response To CAMP Defense Response To Virus Cellular Response To Hydrogen Peroxide Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Peptidoglycan Cellular Response To Nicotine Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Postsynapse To Nucleus Signaling Pathway Antiviral Innate Immune Response Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Amyloid-beta Formation Negative Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Transcription Cellular Response To Angiotensin Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha NoRC negatively regulates rRNA expression RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Loss of MECP2 binding ability to 5mC-DNA Regulation of MECP2 expression and activity MECP2 regulates neuronal receptors and channels MECP2 regulates transcription of neuronal ligands FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes STAT3 nuclear events downstream of ALK signaling Cytoprotection by HMOX1 Regulation of MITF-M-dependent genes involved in apoptosis Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Factors involved in megakaryocyte development and platelet production	Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 Regulated proteolysis of p75NTR Downstream TCR signaling NF-kB is activated and signals survival Senescence-Associated Secretory Phenotype (SASP) FCERI mediated NF-kB activation DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines Transcriptional regulation of white adipocyte differentiation TAK1-dependent IKK and NF-kappa-B activation Interleukin-1 processing SUMOylation of immune response proteins IkBA variant leads to EDA-ID Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling CD209 (DC-SIGN) signaling CLEC7A/inflammasome pathway The NLRP3 inflammasome Transcriptional Regulation by VENTX Interleukin-1 signaling TRAF6 mediated NF-kB activation Purinergic signaling in leishmaniasis infection SARS-CoV-1 activates/modulates innate immune responses Regulation of NFE2L2 gene expression Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Regulation of PD-L1(CD274) transcription
Drugs			Glucosamine Dimethyl fumarate SC-236
Diseases
GWAS		Caffeine consumption from tea ( 33287642) Estimated glomerular filtration rate ( 31152163) Height ( 20189936) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Sudden cardiac arrest ( 21658281) Type 2 diabetes ( 32499647)	Acne (severe) ( 24927181) Asthma ( 31619474) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Inflammatory bowel disease ( 23128233) LDL cholesterol levels ( 32203549) Sensation seeking ( 30718321) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Urate levels ( 31578528 31985003)
Interacting Genes		101 interacting genes: ARID4A ARID4B ATM BCL11A BCL6 BCL6B BHLHE40 BNIP2 BRMS1 BRMS1L CBFA2T2 CEBPA CIAO2A COPS2 CTBP1 CTCF CUL4B CYTOR DACH1 DDB1 DDX20 DHX30 DMRTC1B ETV6 FOXK2 H3-4 HBP1 HCFC1 HDAC1 HDAC2 HDAC7 HDAC9 HEY2 HTT IKZF1 IKZF4 ING1 IRF5 KLF10 KLF11 KLF13 KLF16 KLF9 LRCH4 MAD1L1 MBD2 MBD4 MECP2 MEN1 MNT MORF4L2 MXD1 MXD4 MXI1 MYB NDRG4 NFKB1 NFKB2 NR2E3 OGT PA2G4 PBX3 PHB1 PHF12 PML PRMT5 PTEN PTMA RBBP4 RBBP7 RBP1 RBPJ REL RELA RELB RLIM RUNX1T1 SAP18 SAP30 SETDB1 SFPQ SH3GLB1 SKI SMAD3 SMARCA4 SMARCC1 SMARCE1 SNW1 SPI1 STAT3 SUMO2 SYT1 TAL1 TFCP2 TGIF1 THAP11 TOPORS TP53 TRIM28 TSN ZBTB16	205 interacting genes: AATF ACTL6A AGO1 AHR AKAP8 APBA2 AR ARNT ASB9 AURKA BANP BATF2 BRCA1 BRMS1 BTK BTRC C1QB CALM1 CAMK4 CARM1 CCL5 CCND2 CDC34 CDK9 CEBPB CEBPD CHEK1 CHUK CNNM3 COL2A1 COMMD1 COMMD10 CREBBP CSNK1G1 CSNK2A1 CSNK2A2 DDC DDX1 DHX9 DNAJA3 DNMT3L ECSIT EEF1D EGR1 EP300 EPHA2 ESR1 ETHE1 EZH2 FAF1 FBP1 FBXW2 FKBP11 FOS FUS GLIS1 GOPC GTF2B HDAC1 HDAC2 HDAC3 HEXIM1 HMGA2 HMGB1 HSPA4 IGF1R IKBKB IKBKE ING4 IRAK1BP1 IRF1 IRF2 IRF3 IRF8 IRF9 ISL1 JUN KAT2A KAT2B KAT5 KDM2A KEAP1 KPNA2 LATS2 LMO2 MAP2K6 MAP3K7 MAP3K8 MAPK10 MAPK14 MED15 MED23 MED7 MEN1 MEOX2 MKRN2 MST1R MTPN MX1 MYC NCOA3 NCOA6 NCOR2 NFE2L2 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NKRF NKX2-1 NOTCH1 NPM1 NR3C1 OVOL2 PARP1 PDCD11 PGR PIAS1 PIAS3 PIK3CA PIN1 PKM PLA2G4A PLK1 PML POU2F1 POU6F2 PPARA PPP1R13L PPP2CA PPP2CB PPP2R1B PPP4C PRKACA PRKCZ PRMT1 PRTN3 PSMD10 RAD51 RASSF1 RBCK1 REL RELB REPS2 RFC1 RIOK2 RNASE1 RNF25 RPL13 RPL23 RPS3 RPS6KA5 RTN4IP1 RXRA SAT1 SETD7 SIN3A SIRT1 SMAD3 SNIP1 SNRNP70 SOCS1 SOCS6 SORD SP1 SRF STAT1 STAT3 STAT6 SUOX TAF1 TAF11 TAF4B TAF6 TAF9 TBK1 TBP TCAP TCF4 TERT TGM2 TLE5 TNIP2 TP53 TP53BP1 TP53BP2 TRIB3 TRIM55 TRIM63 TRIP4 TSC22D3 TWIST1 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H UBE2L3 UNC5CL USF2 USP7 ZBTB7A ZBTB7B
Entrez ID		25942	5970
HPRD ID		09690	01241
Ensembl ID		ENSG00000169375	ENSG00000173039
Uniprot IDs		Q96ST3	A0A087X0W8 Q04206
PDB IDs			1NFI 2LSP 2O61 3GUT 3QXY 3RC0 4KV1 4KV4 5U4K 5URN 6NV2 6QHL 6QHM 6YOW 6YOX 6YOY 6YP2 6YP3 6YP8 6YPL 6YPY 6YQ2 7BI3 7BIQ 7BIW 7BIY 7BJB 7BJF 7BJL 7BJW 7BKH 7LET 7LEU 7LF4 7NJ9 7NJB 7NK3 7NK5 7NLA 7NLE 7NM1 7NM3 7NM9 7NMH 7NQP 7NR7 7NSV 7NV4 7NVI 7NWS 7NXS 7NXT 7NXW 7NXY 7NY4 7NYE 7NYF 7NYG 7NZ6 7NZG 7NZK 7NZV 7O34 7O3A 7O3F 7O3P 7O3Q 7O3R 7O3S 7O57 7O59 7O5A 7O5C 7O5D 7O5F 7O5G 7O5O 7O5P 7O5S 7O5U 7O5X 7O6F 7O6G 7O6I 7O6J 7O6K 7O6M 7O6O
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Nucleoplasm Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Primary Metabolic Process DNA Binding Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Sin3-type Complex Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Chromatin Organization Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Population Maintenance Chromatin Binding Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Developmental Process Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Remodeling DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Repressor Complex Epigenetic Regulation Of Gene Expression Transcription Corepressor Activity Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Developmental Process	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Stress Chromatin Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To Stress Macromolecule Metabolic Process DNA-binding Transcription Factor Binding Intracellular Signal Transduction Transcription Cis-regulatory Region Binding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Chromatin Remodeling Rhythmic Process Negative Regulation Of Signal Transduction Nucleic Acid Metabolic Process Cytosol Negative Regulation Of Signaling
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