SIN3A and SMARCE1

Number of citations of the paper that reports this interaction (PMID 14559996)
80

Data Source:
BioGRID (pull down)

		SIN3A	SMARCE1
Gene Name		SIN3 transcription regulator family member A	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Kinetochore Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm Sin3 Complex Transcriptional Repressor Complex Intercellular Bridge	Nuclear Chromosome Nuclear Chromatin Nucleus Nucleoplasm SWI/SNF Complex Transcriptional Repressor Complex Protein Complex NpBAF Complex NBAF Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Repressing Transcription Factor Binding RNA Polymerase II Transcription Corepressor Activity Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Histone Deacetylase Activity Protein Binding Protein Complex Binding Protein Deacetylase Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Chromatin Binding Transcription Coactivator Activity RNA Binding Protein Binding N-acetyltransferase Activity Ligand-dependent Nuclear Receptor Binding Nucleosomal DNA Binding Protein N-terminus Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Hematopoietic Progenitor Cell Differentiation DNA Replication Transcription, DNA-templated Protein Deacetylation Aging Blood Coagulation Response To Organonitrogen Compound Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Histone Deacetylation Positive Regulation Of Chromatin Silencing Cellular Protein Localization Regulation Of Gene Expression, Epigenetic Negative Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Cellular Lipid Metabolic Process Small Molecule Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Response To Methylglyoxal Cellular Response To Glucose Stimulus Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Histone H3-K27 Acetylation Negative Regulation Of Transcription Regulatory Region DNA Binding	Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription From RNA Polymerase II Promoter Nervous System Development Metabolic Process ATP-dependent Chromatin Remodeling Negative Regulation Of Transcription, DNA-templated
Pathways		NoRC negatively regulates rRNA expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Factors involved in megakaryocyte development and platelet production	Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines
Drugs
Diseases
GWAS		Height ( 20189936) Sudden cardiac arrest ( 21658281)
Protein-Protein Interactions		90 interactors: ARID4A ARID4B BCL6 BCL6B BHLHE40 BRMS1 BRMS1L CBFA2T2 COPS2 CTBP1 CTCF CUL4B DACH1 DDB1 DDX20 DHX30 ETV6 HBP1 HCFC1 HDAC1 HDAC2 HDAC7 HDAC9 HEY2 HIST3H3 HTT IKZF1 IKZF4 ING1 IRF5 KLF10 KLF11 KLF13 KLF16 KLF9 LINC00152 LRCH4 MAD1L1 MBD2 MBD4 MECP2 MEN1 MNT MORF4L2 MXD1 MXD3 MXD4 MXI1 MYB NCOR2 NFKB1 NFKB2 NR2E3 OGT PA2G4 PHB PHF12 PML PRMT5 PTMA RBBP4 RBBP7 RBP1 RBPJ REL RELA RELB RLIM RUNX1T1 SAP18 SAP30 SETDB1 SFPQ SKI SMAD3 SMARCA4 SMARCC1 SMARCE1 SNW1 SPI1 STAT3 SYT1 TAL1 TFCP2 TGIF1 THAP11 TOPORS TP53 TRIM28 ZBTB16	63 interactors: AMOTL2 AR ARID2 BAZ1B BRMS1 CCDC136 CCDC172 CDR2 CEP170P1 CEP63 CEP70 DISC1 EPS8 ESR1 ESR2 EXOC7 GATA1 GOLGA2 ING5 ITCH JAKMIP2 KIFC3 KLF1 KRT15 KRT31 KRT40 KRTAP10-9 MDM2 MED4 MEOX2 MIPOL1 MRFAP1L1 MTUS2 NBPF22P NCOA1 NCOA2 NCOA3 NOTCH2NL NR0B2 NR3C1 NUP62 PGR PRMT5 RALBP1 RARA RCOR1 RELB RINT1 SIN3A SIN3B SMAD1 SMARCA4 SPAG5 SRC STX11 SYCE1 TFE3 TFIP11 TNIK TRIM54 TRIP10 TXLNA USHBP1
Entrez ID		25942	6605
HPRD ID		09690	04382
Ensembl ID		ENSG00000169375	ENSG00000073584
Uniprot IDs		Q96ST3	Q969G3
PDB IDs		1PO4
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Chromatin Organization Chromatin Modification Chromosome Organization Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Regulation Of Cellular Process Histone Modification Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Proliferation Regulation Of Gene Expression, Epigenetic Positive Regulation Of Metabolic Process Regulation Of Cell Proliferation Negative Regulation Of Gene Expression, Epigenetic Organelle Organization Regulation Of Cell Differentiation Regulation Of Chromosome Organization Regulation Of Histone Modification Cell Differentiation	Intracellular Steroid Hormone Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Transcription, DNA-templated Positive Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Organelle Organization Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Modification Transcription From RNA Polymerase II Promoter Chromosome Organization RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Hormone Stimulus Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Cellular Response To Steroid Hormone Stimulus Hormone-mediated Signaling Pathway Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Histone Modification Negative Regulation Of Gene Expression Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Hormone Gland Development Cellular Response To Organic Cyclic Compound Nucleobase-containing Compound Metabolic Process DNA-templated Transcription, Initiation Negative Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Steroid Hormone Negative Regulation Of Nucleic Acid-templated Transcription Organ Development Negative Regulation Of RNA Biosynthetic Process Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Signal Transduction
Tagcloud ?		ablated bcl6 conducive cor corepressors deacteylases erbaalpha erbbeta interactiondomains laz3 locks mad mxi physicalassociation rev rid rids rip13a rip13delta1 rpd3 rvr sin3b tafii32 tafii70 tafs terminalrepression tfiib zip	acetylase aldh1a3 belonging bipotent cbx6 ccnb1 ccne1 committed differentiated disrupt dysregulation encode establishment gata3 hat1 hdac1 identity luminal maintenance myoepithelial notch4 pcgf2 polycomb progenitors silico subpopulations trithorax
Tagcloud (Difference) ?		ablated bcl6 conducive cor corepressors deacteylases erbaalpha erbbeta interactiondomains laz3 locks mad mxi physicalassociation rev rid rids rip13a rip13delta1 rpd3 rvr sin3b tafii32 tafii70 tafs terminalrepression tfiib zip	acetylase aldh1a3 belonging bipotent cbx6 ccnb1 ccne1 committed differentiated disrupt dysregulation encode establishment gata3 hat1 hdac1 identity luminal maintenance myoepithelial notch4 pcgf2 polycomb progenitors silico subpopulations trithorax
Tagcloud (Intersection) ?