SIN3A and FOXK2

Number of citations of the paper that reports this interaction (PubMedID 25609649)
81

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down)

		SIN3A	FOXK2
Description		SIN3 transcription regulator family member A	forkhead box K2
Image		No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Kinetochore Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Nucleolus Transcription Repressor Complex Protein-containing Complex Sin3-type Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion
	Molecular Function	DNA Binding Chromatin Binding Transcription Corepressor Activity RNA Binding Protein Binding Protein-containing Complex Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity	Magnesium Ion Binding Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Hematopoietic Progenitor Cell Differentiation DNA Replication Regulation Of DNA-templated Transcription Intracellular Protein Localization Regulation Of Hormone Levels Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cerebral Cortex Neuron Differentiation Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Axon Extension Heterochromatin Formation Negative Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Differentiation Negative Regulation Of DNA-templated Transcription Rhythmic Process Response To Methylglyoxal Type I Interferon-mediated Signaling Pathway Cellular Response To Glucose Stimulus Cellular Response To Tert-butyl Hydroperoxide Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Cellular Response To Dopamine	Negative Regulation Of Transcription By RNA Polymerase II Intracellular Glucose Homeostasis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Autophagy Regulation Of Glucose Metabolic Process Response To Starvation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Canonical Glycolysis
Pathways		SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha NoRC negatively regulates rRNA expression RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Loss of MECP2 binding ability to 5mC-DNA Regulation of MECP2 expression and activity MECP2 regulates neuronal receptors and channels MECP2 regulates transcription of neuronal ligands FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes STAT3 nuclear events downstream of ALK signaling Cytoprotection by HMOX1 Regulation of MITF-M-dependent genes involved in apoptosis Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Factors involved in megakaryocyte development and platelet production	UCH proteinases
Drugs
Diseases
GWAS		Caffeine consumption from tea ( 33287642) Estimated glomerular filtration rate ( 31152163) Height ( 20189936) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Sudden cardiac arrest ( 21658281) Type 2 diabetes ( 32499647)	Appendicular lean mass ( 33097823) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lean body mass ( 28552196) Letter-number span reordering ( 31596458) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 28957414 27863252 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		101 interacting genes: ARID4A ARID4B ATM BCL11A BCL6 BCL6B BHLHE40 BNIP2 BRMS1 BRMS1L CBFA2T2 CEBPA CIAO2A COPS2 CTBP1 CTCF CUL4B CYTOR DACH1 DDB1 DDX20 DHX30 DMRTC1B ETV6 FOXK2 H3-4 HBP1 HCFC1 HDAC1 HDAC2 HDAC7 HDAC9 HEY2 HTT IKZF1 IKZF4 ING1 IRF5 KLF10 KLF11 KLF13 KLF16 KLF9 LRCH4 MAD1L1 MBD2 MBD4 MECP2 MEN1 MNT MORF4L2 MXD1 MXD4 MXI1 MYB NDRG4 NFKB1 NFKB2 NR2E3 OGT PA2G4 PBX3 PHB1 PHF12 PML PRMT5 PTEN PTMA RBBP4 RBBP7 RBP1 RBPJ REL RELA RELB RLIM RUNX1T1 SAP18 SAP30 SETDB1 SFPQ SH3GLB1 SKI SMAD3 SMARCA4 SMARCC1 SMARCE1 SNW1 SPI1 STAT3 SUMO2 SYT1 TAL1 TFCP2 TGIF1 THAP11 TOPORS TP53 TRIM28 TSN ZBTB16	9 interacting genes: ESR1 HCFC1 IL2 MTA3 RBBP4 RCOR1 SIN3A TBL1X TBL1XR1
Entrez ID		25942	3607
HPRD ID		09690	00982
Ensembl ID		ENSG00000169375	ENSG00000141568
Uniprot IDs		Q96ST3	Q01167
PDB IDs			1JXS 2C6Y
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Nucleoplasm Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Primary Metabolic Process DNA Binding Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Sin3-type Complex Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Chromatin Organization Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Population Maintenance Chromatin Binding Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Developmental Process Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Remodeling DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Repressor Complex Epigenetic Regulation Of Gene Expression Transcription Corepressor Activity Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Developmental Process	Histone Deacetylase Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Organization Transcription Repressor Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Corepressor Activity Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Chromatin Remodeling Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process NuRD Complex Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Sin3-type Complex Positive Regulation Of Biosynthetic Process Regulation Of Cell Fate Specification Regulation Of Metabolic Process Negative Regulation Of Stem Cell Population Maintenance Histone Binding Blastocyst Hatching Histone Methyltransferase Complex Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Transcription Regulator Complex Regulation Of Cell Fate Commitment Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Metabolic Process Protein-containing Complex Regulation Of Developmental Process Kappa-type Opioid Receptor Binding
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