SIN3A and TFCP2

Number of citations of the paper that reports this interaction (PMID 11884454)
10

Data Source:
BioGRID (pull down)

		SIN3A	TFCP2
Gene Name		SIN3 transcription regulator family member A	transcription factor CP2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Kinetochore Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm Sin3 Complex Transcriptional Repressor Complex Intercellular Bridge	Cellular_component Nucleus
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Repressing Transcription Factor Binding RNA Polymerase II Transcription Corepressor Activity Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Histone Deacetylase Activity Protein Binding Protein Complex Binding Protein Deacetylase Activity	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Hematopoietic Progenitor Cell Differentiation DNA Replication Transcription, DNA-templated Protein Deacetylation Aging Blood Coagulation Response To Organonitrogen Compound Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Histone Deacetylation Positive Regulation Of Chromatin Silencing Cellular Protein Localization Regulation Of Gene Expression, Epigenetic Negative Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Cellular Lipid Metabolic Process Small Molecule Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Response To Methylglyoxal Cellular Response To Glucose Stimulus Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Histone H3-K27 Acetylation Negative Regulation Of Transcription Regulatory Region DNA Binding	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		NoRC negatively regulates rRNA expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Height ( 20189936) Sudden cardiac arrest ( 21658281)
Protein-Protein Interactions		90 interactors: ARID4A ARID4B BCL6 BCL6B BHLHE40 BRMS1 BRMS1L CBFA2T2 COPS2 CTBP1 CTCF CUL4B DACH1 DDB1 DDX20 DHX30 ETV6 HBP1 HCFC1 HDAC1 HDAC2 HDAC7 HDAC9 HEY2 HIST3H3 HTT IKZF1 IKZF4 ING1 IRF5 KLF10 KLF11 KLF13 KLF16 KLF9 LINC00152 LRCH4 MAD1L1 MBD2 MBD4 MECP2 MEN1 MNT MORF4L2 MXD1 MXD3 MXD4 MXI1 MYB NCOR2 NFKB1 NFKB2 NR2E3 OGT PA2G4 PHB PHF12 PML PRMT5 PTMA RBBP4 RBBP7 RBP1 RBPJ REL RELA RELB RLIM RUNX1T1 SAP18 SAP30 SETDB1 SFPQ SKI SMAD3 SMARCA4 SMARCC1 SMARCE1 SNW1 SPI1 STAT3 SYT1 TAL1 TFCP2 TGIF1 THAP11 TOPORS TP53 TRIM28 ZBTB16	62 interactors: ADPRH APBB1 ASAP3 BAG6 C19orf73 CA1 CASP8 CBX8 CCDC94 CDC73 COIL DNAJC27 DNAJC5B DPH1 E2F8 EAF1 EIF5B EPHA10 FAM64A FANCL FARS2 FBXL18 GPANK1 HDAC1 HDAC2 IRAK1BP1 KIAA1598 MAPK1 MAPK14 MAPK8 MOB3C MORF4L1 MRPL11 MRPL40 MVP NABP1 NFE4 NOM1 NPEPL1 PHF1 PITPNM1 PLCB1 POLL POLR3GL PPIG PPP1R1B PPP3R2 PSMD5 RBMS1 RNF2 SDCBP SIN3A STMN2 SUMO1 TCEA2 TDRD1 TRAPPC12 TSPAN12 UBP1 YY1 ZCCHC10 ZCCHC12
Entrez ID		25942	7024
HPRD ID		09690	01790
Ensembl ID		ENSG00000169375	ENSG00000135457
Uniprot IDs		Q96ST3	Q12800
PDB IDs		1PO4
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Chromatin Organization Chromatin Modification Chromosome Organization Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Regulation Of Cellular Process Histone Modification Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Proliferation Regulation Of Gene Expression, Epigenetic Positive Regulation Of Metabolic Process Regulation Of Cell Proliferation Negative Regulation Of Gene Expression, Epigenetic Organelle Organization Regulation Of Cell Differentiation Regulation Of Chromosome Organization Regulation Of Histone Modification Cell Differentiation	Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Metabolic Process Cellular Response To Stress Chromatin Modification Cellular Protein Metabolic Process Histone Modification Chromatin Organization Negative Regulation Of Gene Expression Cell Cycle Negative Regulation Of Cellular Metabolic Process Protein Metabolic Process Histone Deacetylation Regulation Of Gene Expression Chromosome Organization Regulation Of Metabolic Process Protein Deacetylation TRIF-dependent Toll-like Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Innate Immune Response Activation Of Innate Immune Response Metabolic Process Negative Regulation Of Transcription, DNA-templated Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Biosynthetic Process Regulation Of Organelle Organization Negative Regulation Of Gene Expression, Epigenetic Cellular Protein Modification Process Negative Regulation Of RNA Biosynthetic Process Peptidyl-amino Acid Modification Toll-like Receptor 4 Signaling Pathway Anatomical Structure Development Anatomical Structure Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated
Tagcloud ?		ablated bcl6 conducive cor corepressors deacteylases erbaalpha erbbeta interactiondomains laz3 locks mad mxi physicalassociation rev rid rids rip13a rip13delta1 rpd3 rvr sin3b tafii32 tafii70 tafs terminalrepression tfiib zip
Tagcloud (Difference) ?		ablated bcl6 conducive cor corepressors deacteylases erbaalpha erbbeta interactiondomains laz3 locks mad mxi physicalassociation rev rid rids rip13a rip13delta1 rpd3 rvr sin3b tafii32 tafii70 tafs terminalrepression tfiib zip
Tagcloud (Intersection) ?