RIPK4 and WDR19

Number of citations: 83 (PubMedID 35914814)
Data Source: BioGRID (two hybrid)

		RIPK4	WDR19
Name		receptor interacting serine/threonine kinase 4	WD repeat domain 19
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane	Photoreceptor Outer Segment Cytoplasm Cytoskeleton Plasma Membrane Cilium Intraciliary Transport Particle A Motile Cilium Photoreceptor Connecting Cilium Cell Projection Ciliary Tip Non-motile Cilium
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Protein Binding
	Biological Process	Morphogenesis Of An Epithelium Skin Development Positive Regulation Of NF-kappaB Transcription Factor Activity	Cell Morphogenesis In Utero Embryonic Development Smoothened Signaling Pathway Gonad Development Cell Projection Organization Embryonic Limb Morphogenesis Embryonic Camera-type Eye Development Intraciliary Retrograde Transport Ear Morphogenesis Receptor Clustering Cilium Organization Embryonic Cranial Skeleton Morphogenesis Nervous System Process Digestive System Development Cilium Assembly Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Myotome Development Protein-containing Complex Assembly Protein Localization To Membrane Protein Localization To Ciliary Membrane
Pathways		None	Hedgehog 'off' state Intraflagellar transport
Diseases		None	Asphyxiating thoracic dystrophy; Jeune syndrome
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847 ) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683 )	Cognitive function ( 24684796 ) Sensorimotor dexterity ( 31596458 )
Interacting Genes		38 interacting genes: ANK2 ANK3 ANKRD6 ASB3 BIRC2 BIRC3 BTRC CARS2 CLTC CTBP1 FBXW11 GPSM3 HSPA5 KPNA1 LINC01537 MACF1 MAGI2 MIB1 MICU1 MTPN MYO1E NAPA PADI2 PREPL PRKCB PRKCD PTPRK RPL13 SPAG8 SPAST STAM TNPO2 TRAF7 UBE4B VCP VWC2L WDR19 XIAP	2 interacting genes: PTGER4 RIPK4
Entrez ID		54101	57728
HPRD ID		10419	10489
Ensembl ID		ENSG00000183421	ENSG00000157796
Uniprot IDs		Q96T11 Q9H4D1	B4DGR6 Q8NEZ3
PDB IDs		Not available	8BBF 8BBG 8FGW 8FH3
GO Terms Enriched among Interactors		Cytoplasm Canonical NF-kappaB Signal Transduction Cellular Localization Signal Transduction Vesicle-mediated Transport Intracellular Protein Localization Protein Transport Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein Ubiquitination Post-translational Protein Modification Positive Regulation Of Post-translational Protein Modification Intracellular Signaling Cassette Establishment Of Protein Localization Ubiquitin Protein Ligase Activity Mitotic Spindle Disassembly Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Modification Process Protein Kinase C Signaling Golgi Vesicle Transport Protein Polyubiquitination Intracellular Transport Regulation Of Cell Communication Non-canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Protein Localization To Membrane Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Golgi To Plasma Membrane Protein Transport Regulation Of Canonical NF-kappaB Signal Transduction Intracellular Signal Transduction Regulation Of Wnt Signaling Pathway Establishment Of Localization In Cell Positive Regulation Of Protein Ubiquitination Channel Activator Activity Proteolysis Involved In Protein Catabolic Process Protein Localization To Cell Periphery Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Intracellular Protein Transport Negative Regulation Of Signal Transduction Regulation Of Post-translational Protein Modification Cytosol Ubiquitin-dependent Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Modification-dependent Protein Catabolic Process Cytoskeleton Positive Regulation Of Membrane Potential Establishment Of Protein Localization To Plasma Membrane	Negative Regulation Of Eosinophil Extravasation Negative Regulation Of Integrin Activation Negative Regulation Of Eosinophil Migration Prostaglandin Receptor Activity Prostaglandin E Receptor Activity Negative Regulation Of Cellular Extravasation Regulation Of Integrin Activation Cellular Response To Prostaglandin E Stimulus T-helper Cell Differentiation Regulation Of Cellular Extravasation Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E T Cell Differentiation Involved In Immune Response