RIPK4 and MYO1E

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		RIPK4	MYO1E
Description		receptor interacting serine/threonine kinase 4	myosin IE
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane	Cytoplasm Cytoskeleton Plasma Membrane Microvillus Brush Border Adherens Junction Actin Cytoskeleton Myosin Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Clathrin-coated Endocytic Vesicle Extracellular Exosome Anchoring Junction
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Lipid Binding ATP Hydrolysis Activity Phosphatidylinositol Binding Actin Filament Binding
	Biological Process	Morphogenesis Of An Epithelium Skin Development Positive Regulation Of NF-kappaB Transcription Factor Activity	Vasculogenesis In Utero Embryonic Development Kidney Development Glomerular Filtration Endocytosis Actin Filament Organization Hemopoiesis Glomerulus Development Glomerular Basement Membrane Development Post-embryonic Hemopoiesis Platelet-derived Growth Factor Receptor Signaling Pathway Podocyte Development
Pathways
Drugs			Imidazole
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Adult body size ( 32376654) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Metabolite levels ( 22916037) Plateletcrit ( 32888494) Pulse pressure ( 30224653) Serum metabolite levels (CMS) ( 31636271) Social communication problems ( 24047820)
Interacting Genes		38 interacting genes: ANK2 ANK3 ANKRD6 ASB3 BIRC2 BIRC3 BTRC CARS2 CLTC CTBP1 FBXW11 GPSM3 HSPA5 KPNA1 LINC01537 MACF1 MAGI2 MIB1 MICU1 MTPN MYO1E NAPA PADI2 PREPL PRKCB PRKCD PTPRK RPL13 SPAG8 SPAST STAM TNPO2 TRAF7 UBE4B VCP VWC2L WDR19 XIAP	7 interacting genes: ACTB CLIC6 CREBBP LTB4R2 PDE4B RIPK4 SRPK2
Entrez ID		54101	4643
HPRD ID		10419	03281
Ensembl ID		ENSG00000183421	ENSG00000157483
Uniprot IDs		Q96T11 Q9H4D1	Q12965 Q4KMR3
PDB IDs
Enriched GO Terms of Interacting Partners?		Cytoplasm Canonical NF-kappaB Signal Transduction Cellular Localization Signal Transduction Vesicle-mediated Transport Intracellular Protein Localization Protein Transport Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein Ubiquitination Post-translational Protein Modification Positive Regulation Of Post-translational Protein Modification Intracellular Signaling Cassette Establishment Of Protein Localization Ubiquitin Protein Ligase Activity Mitotic Spindle Disassembly Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Modification Process Protein Kinase C Signaling Golgi Vesicle Transport Protein Polyubiquitination Intracellular Transport Regulation Of Cell Communication Non-canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Protein Localization To Membrane Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Golgi To Plasma Membrane Protein Transport Regulation Of Canonical NF-kappaB Signal Transduction Intracellular Signal Transduction Regulation Of Wnt Signaling Pathway Establishment Of Localization In Cell Positive Regulation Of Protein Ubiquitination Channel Activator Activity Proteolysis Involved In Protein Catabolic Process Protein Localization To Cell Periphery Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Intracellular Protein Transport Negative Regulation Of Signal Transduction Regulation Of Post-translational Protein Modification Cytosol Ubiquitin-dependent Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Modification-dependent Protein Catabolic Process Cytoskeleton Positive Regulation Of Membrane Potential Establishment Of Protein Localization To Plasma Membrane	Positive Regulation Of Double-strand Break Repair Positive Regulation Of DNA Recombination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Chromatin Regulation Of Double-strand Break Repair Via Homologous Recombination Tau Protein Binding Multicellular Organismal-level Homeostasis Regulation Of Norepinephrine Uptake Positive Regulation Of Norepinephrine Uptake Transporter Regulator Activity Cellular Response To Cytochalasin B Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K27 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Zygotic Specification Of Dorsal/ventral Axis Type I Activin Receptor Binding Negative Regulation Of Relaxation Of Cardiac Muscle D2 Dopamine Receptor Binding D4 Dopamine Receptor Binding D3 Dopamine Receptor Binding Leukotriene B4 Receptor Activity Leukotriene Receptor Activity Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Positive Regulation Of DNA Repair Regulation Of Transepithelial Transport Protein Localization To Adherens Junction Dense Body MRF Binding Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Nuclear Speck Organization Leukotriene Signaling Pathway Chromatin Remodeling Anatomical Structure Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Morphogenesis Of A Polarized Epithelium Activin Receptor Binding Regulation Of Relaxation Of Cardiac Muscle Keratinocyte Migration Structural Constituent Of Postsynaptic Actin Cytoskeleton Negative Regulation Of Relaxation Of Muscle Positive Regulation Of Biosynthetic Process
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