RIPK4 and MICU1

Number of citations: 83 (PubMedID 35914814)
Data Source: BioGRID (two hybrid)

		RIPK4	MICU1
Name		receptor interacting serine/threonine kinase 4	mitochondrial calcium uptake 1
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Membrane Mitochondrial Membrane Calcium Channel Complex Mitochondrial Crista Junction Uniplex Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Calcium Channel Inhibitor Activity Identical Protein Binding Metal Ion Binding Protein Heterodimerization Activity Calcium Ion Sensor Activity
	Biological Process	Morphogenesis Of An Epithelium Skin Development Positive Regulation Of NF-kappaB Transcription Factor Activity	Monoatomic Ion Transport Calcium Ion Transport Mitochondrial Calcium Ion Transmembrane Transport Defense Response Calcium Import Into The Mitochondrion Protein Homooligomerization Mitochondrial Calcium Ion Homeostasis Positive Regulation Of Mitochondrial Calcium Ion Concentration Calcium Ion Import Cellular Response To Calcium Ion Cellular Response To Calcium Ion Starvation Regulation Of Cellular Hyperosmotic Salinity Response Positive Regulation Of Cristae Formation
Pathways		None	Mitochondrial calcium ion transport Processing of SMDT1
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847 ) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683 )	Refractive error ( 32231278 )
Interacting Genes		38 interacting genes: ANK2 ANK3 ANKRD6 ASB3 BIRC2 BIRC3 BTRC CARS2 CLTC CTBP1 FBXW11 GPSM3 HSPA5 KPNA1 LINC01537 MACF1 MAGI2 MIB1 MICU1 MTPN MYO1E NAPA PADI2 PREPL PRKCB PRKCD PTPRK RPL13 SPAG8 SPAST STAM TNPO2 TRAF7 UBE4B VCP VWC2L WDR19 XIAP	4 interacting genes: APP OGT RIPK4 UBC
Entrez ID		54101	10367
HPRD ID		10419	05471
Ensembl ID		ENSG00000183421	ENSG00000107745
Uniprot IDs		Q96T11 Q9H4D1	A0A286YF11 Q9BPX6
PDB IDs		Not available	4NSC 4NSD 6K7Y 6LB7 6LB8 6LE5 6WDN 6WDO 6XJV 6XJX 6XQN 6XQO
GO Terms Enriched among Interactors		Cytoplasm Canonical NF-kappaB Signal Transduction Cellular Localization Signal Transduction Vesicle-mediated Transport Intracellular Protein Localization Protein Transport Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein Ubiquitination Post-translational Protein Modification Positive Regulation Of Post-translational Protein Modification Intracellular Signaling Cassette Establishment Of Protein Localization Ubiquitin Protein Ligase Activity Mitotic Spindle Disassembly Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Modification Process Protein Kinase C Signaling Golgi Vesicle Transport Protein Polyubiquitination Intracellular Transport Regulation Of Cell Communication Non-canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Protein Localization To Membrane Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Golgi To Plasma Membrane Protein Transport Regulation Of Canonical NF-kappaB Signal Transduction Intracellular Signal Transduction Regulation Of Wnt Signaling Pathway Establishment Of Localization In Cell Positive Regulation Of Protein Ubiquitination Channel Activator Activity Proteolysis Involved In Protein Catabolic Process Protein Localization To Cell Periphery Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Intracellular Protein Transport Negative Regulation Of Signal Transduction Regulation Of Post-translational Protein Modification Cytosol Ubiquitin-dependent Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Modification-dependent Protein Catabolic Process Cytoskeleton Positive Regulation Of Membrane Potential Establishment Of Protein Localization To Plasma Membrane	Amyloid-beta Complex Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of Toll Signaling Pathway Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Synapse Assembly Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Hemopoiesis Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Generation Of Precursor Metabolites And Energy Protein O-acetylglucosaminyltransferase Activity Positive Regulation Of Proteolysis Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Cell Junction Assembly Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Axon Choice Point Recognition Carbon Catabolite Regulation Of Transcription Regulation Of Synapse Organization