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RIPK4 and XIAP
Number of citations of the paper that reports this interaction (PubMedID
21931591
)
59
Data Source:
BioGRID
(pull down, enzymatic study)
RIPK4
XIAP
Description
receptor interacting serine/threonine kinase 4
X-linked inhibitor of apoptosis
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Serine Kinase Activity
Ubiquitin-protein Transferase Activity
Cysteine-type Endopeptidase Inhibitor Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Peptidase Inhibitor Activity
Identical Protein Binding
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Protein Serine/threonine Kinase Binding
Biological Process
Morphogenesis Of An Epithelium
Skin Development
Positive Regulation Of NF-kappaB Transcription Factor Activity
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
DNA Damage Response
Canonical NF-kappaB Signal Transduction
Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Wnt Signaling Pathway
Regulation Of BMP Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Negative Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Response To Lipopolysaccharide
P38MAPK Cascade
Defense Response To Bacterium
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Innate Immune Response
Positive Regulation Of JNK Cascade
Regulation Of Inflammatory Response
Neuron Apoptotic Process
Regulation Of Cell Cycle
Copper Ion Homeostasis
Regulation Of Apoptosis Involved In Tissue Homeostasis
Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Protein K63-linked Ubiquitination
Positive Regulation Of Canonical Wnt Signaling Pathway
Protein Linear Polyubiquitination
Execution Phase Of Apoptosis
Positive Regulation Of Protein Linear Polyubiquitination
Pathways
Activation of caspases through apoptosome-mediated cleavage
SMAC (DIABLO) binds to IAPs
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
SMAC, XIAP-regulated apoptotic response
Deactivation of the beta-catenin transactivating complex
RIPK1-mediated regulated necrosis
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
Regulation of necroptotic cell death
Regulation of PTEN localization
Regulation of PTEN stability and activity
Regulation of the apoptosome activity
Drugs
1-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-Amide
Dequalinium
N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE
AEG35156
Terpinen-4-ol
Diseases
Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS
Femur bone mineral density x serum urate levels interaction (
34046847
)
Venous thromboembolism adjusted for sickle cell variant rs77121243-T (
28203683
)
Interacting Genes
38 interacting genes:
ANK2
ANK3
ANKRD6
ASB3
BIRC2
BIRC3
BTRC
CARS2
CLTC
CTBP1
FBXW11
GPSM3
HSPA5
KPNA1
LINC01537
MACF1
MAGI2
MIB1
MICU1
MTPN
MYO1E
NAPA
PADI2
PREPL
PRKCB
PRKCD
PTPRK
RPL13
SPAG8
SPAST
STAM
TNPO2
TRAF7
UBE4B
VCP
VWC2L
WDR19
XIAP
105 interacting genes:
ACVRL1
AFP
AIFM1
AKT1
AKT2
BCL2
BIRC5
BOLA1
BOLA2
BOLA2B
BRCA1
CAD
CASP10
CASP3
CASP7
CASP9
CCNB1
CDC42
CDK1
CHEK1
CKS1B
COMMD1
DIABLO
DNM2
DTX3
DYNLL2
EEF2
ERCC3
FAF1
FLNA
FLNB
GCC1
GOLGA2
GSK3B
GSPT1
HNRNPA1
HSP90AB1
HSPA1A
HTRA1
HTRA2
HTRA3
IKBKE
INPP5D
KCNJ6
LIMA1
LONRF1
MAGED1
MAP3K2
MAP3K3
MAP3K7
MCRS1
MDM2
NCOA6
NEK6
NOD1
NOD2
NOTCH1
NTAQ1
OGT
PGAM5
PIBF1
PPIH
PPM1K
QARS1
RAF1
RFC5
RIPK3
RIPK4
RPS9
RUNX1T1
SDHA
SEPTIN4
SERPINA12
SERTAD1
SSX2IP
STRADB
STUB1
SYNE1
TAB1
TAB2
TBK1
TGFBR1
TPM3
TRAF6
TRIM32
TRIM8
TTC23
TUFM
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2I
UBE2J2
UBE2L3
UBE2N
UBE2V1
UBE2V2
UBE2W
VPS37C
XAF1
Entrez ID
54101
331
HPRD ID
10419
02094
Ensembl ID
ENSG00000183421
ENSG00000101966
Uniprot IDs
Q96T11
Q9H4D1
B2R9R2
P98170
PDB IDs
1C9Q
1F9X
1G3F
1G73
1I3O
1I4O
1I51
1KMC
1NW9
1TFQ
1TFT
2ECG
2JK7
2KNA
2OPY
2OPZ
2POI
2POP
2QRA
2VSL
3CLX
3CM2
3CM7
3EYL
3G76
3HL5
3UW4
3UW5
4EC4
4HY0
4IC2
4IC3
4J3Y
4J44
4J45
4J46
4J47
4J48
4KJU
4KJV
4KMP
4MTZ
4OXC
4WVS
4WVT
4WVU
5C0K
5C0L
5C3H
5C3K
5C7A
5C7B
5C7C
5C7D
5C83
5C84
5M6E
5M6F
5M6H
5M6L
5M6M
5O6T
5OQW
6EY2
6GJW
6QCI
8AZA
8GH7
8W59
8W5A
Enriched GO Terms of Interacting Partners
?
Cytoplasm
Canonical NF-kappaB Signal Transduction
Cellular Localization
Signal Transduction
Vesicle-mediated Transport
Intracellular Protein Localization
Protein Transport
Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Protein Ubiquitination
Post-translational Protein Modification
Positive Regulation Of Post-translational Protein Modification
Intracellular Signaling Cassette
Establishment Of Protein Localization
Ubiquitin Protein Ligase Activity
Mitotic Spindle Disassembly
Protein Modification By Small Protein Conjugation
Ubiquitin-protein Transferase Activity
Protein Modification Process
Protein Kinase C Signaling
Golgi Vesicle Transport
Protein Polyubiquitination
Intracellular Transport
Regulation Of Cell Communication
Non-canonical NF-kappaB Signal Transduction
Cell Surface Receptor Signaling Pathway
Protein Localization To Membrane
Positive Regulation Of Protein Metabolic Process
Protein Metabolic Process
Golgi To Plasma Membrane Protein Transport
Regulation Of Canonical NF-kappaB Signal Transduction
Intracellular Signal Transduction
Regulation Of Wnt Signaling Pathway
Establishment Of Localization In Cell
Positive Regulation Of Protein Ubiquitination
Channel Activator Activity
Proteolysis Involved In Protein Catabolic Process
Protein Localization To Cell Periphery
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Macromolecule Metabolic Process
Intracellular Protein Transport
Negative Regulation Of Signal Transduction
Regulation Of Post-translational Protein Modification
Cytosol
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Canonical Wnt Signaling Pathway
Modification-dependent Protein Catabolic Process
Cytoskeleton
Positive Regulation Of Membrane Potential
Establishment Of Protein Localization To Plasma Membrane
Protein Metabolic Process
Protein Modification Process
Protein Polyubiquitination
Cytosol
Macromolecule Metabolic Process
Regulation Of Intracellular Signal Transduction
Ubiquitin Conjugating Enzyme Activity
Regulation Of Signal Transduction
Nucleotide Binding
Programmed Cell Death
Cell Death
Regulation Of Protein Ubiquitination
Regulation Of Programmed Cell Death
Positive Regulation Of Protein Metabolic Process
Regulation Of Apoptotic Process
Post-translational Protein Modification
ATP Binding
Protein Ubiquitination
Ubiquitin Protein Ligase Binding
Cytoplasm
Regulation Of Signaling
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Cell Communication
Protein Modification By Small Protein Conjugation
Apoptotic Process
Regulation Of Protein Modification Process
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Protein Modification Process
Regulation Of Post-translational Protein Modification
Cellular Response To Stress
Positive Regulation Of Signal Transduction
Protein K63-linked Ubiquitination
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Apoptotic Process
Intracellular Signal Transduction
Regulation Of Protein Metabolic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Protein Ubiquitination
Protein-containing Complex
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Protein Binding
Transferase Activity
Positive Regulation Of Post-translational Protein Modification
Modification-dependent Protein Catabolic Process
Proteolysis
Macromolecule Catabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Signal Transduction
Regulation Of Apoptotic Signaling Pathway
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