RIPK4 and MTPN

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		RIPK4	MTPN
Description		receptor interacting serine/threonine kinase 4	myotrophin
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane	Nucleus Cytoplasm Cytosol F-actin Capping Protein Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Morphogenesis Of An Epithelium Skin Development Positive Regulation Of NF-kappaB Transcription Factor Activity	Regulation Of Translation Regulation Of Cell Size Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Striated Muscle Tissue Development Neuron Differentiation Positive Regulation Of Cell Growth Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Metabolic Process Regulation Of Barbed-end Actin Filament Capping
Pathways
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Alcoholic chronic pancreatitis ( 28754779) Mean platelet volume ( 32888494) Platelet count ( 27863252) Platelet distribution width ( 27863252 32888494) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		38 interacting genes: ANK2 ANK3 ANKRD6 ASB3 BIRC2 BIRC3 BTRC CARS2 CLTC CTBP1 FBXW11 GPSM3 HSPA5 KPNA1 LINC01537 MACF1 MAGI2 MIB1 MICU1 MTPN MYO1E NAPA PADI2 PREPL PRKCB PRKCD PTPRK RPL13 SPAG8 SPAST STAM TNPO2 TRAF7 UBE4B VCP VWC2L WDR19 XIAP	7 interacting genes: CAPZB CEBPA MAPK1 NFKB1 REL RELA RIPK4
Entrez ID		54101	136319
HPRD ID		10419	07574
Ensembl ID		ENSG00000183421	ENSG00000105887
Uniprot IDs		Q96T11 Q9H4D1	P58546 Q69YG1
PDB IDs			3AAA 7DF7 7DSA 7DSB
Enriched GO Terms of Interacting Partners?		Cytoplasm Canonical NF-kappaB Signal Transduction Cellular Localization Signal Transduction Vesicle-mediated Transport Intracellular Protein Localization Protein Transport Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein Ubiquitination Post-translational Protein Modification Positive Regulation Of Post-translational Protein Modification Intracellular Signaling Cassette Establishment Of Protein Localization Ubiquitin Protein Ligase Activity Mitotic Spindle Disassembly Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Modification Process Protein Kinase C Signaling Golgi Vesicle Transport Protein Polyubiquitination Intracellular Transport Regulation Of Cell Communication Non-canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Protein Localization To Membrane Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Golgi To Plasma Membrane Protein Transport Regulation Of Canonical NF-kappaB Signal Transduction Intracellular Signal Transduction Regulation Of Wnt Signaling Pathway Establishment Of Localization In Cell Positive Regulation Of Protein Ubiquitination Channel Activator Activity Proteolysis Involved In Protein Catabolic Process Protein Localization To Cell Periphery Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Intracellular Protein Transport Negative Regulation Of Signal Transduction Regulation Of Post-translational Protein Modification Cytosol Ubiquitin-dependent Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Modification-dependent Protein Catabolic Process Cytoskeleton Positive Regulation Of Membrane Potential Establishment Of Protein Localization To Plasma Membrane	Response To Peptide Response To Cytokine Cellular Response To Tumor Necrosis Factor Response To Tumor Necrosis Factor NF-kappaB P50/p65 Complex Non-canonical NF-kappaB Signal Transduction Cellular Response To Cytokine Stimulus Response To Nicotine NF-kappaB Complex Canonical NF-kappaB Signal Transduction Cellular Response To Nicotine Intracellular Signaling Cassette Actinin Binding Cytokine-mediated Signaling Pathway Regulation Of Inflammatory Response Cellular Response To Angiotensin Cellular Response To Interleukin-6 DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Immune System Process Sequence-specific DNA Binding Positive Regulation Of Defense Response Response To Interleukin-6 Positive Regulation Of Inflammatory Response Response To Angiotensin Inflammatory Response Response To Muscle Stretch Signal Transduction Involved In Regulation Of Gene Expression DNA-binding Transcription Factor Activity Transcription Regulator Complex Immune Response-activating Cell Surface Receptor Signaling Pathway Transcription Cis-regulatory Region Binding Negative Regulation Of Cytokine Production Involved In Inflammatory Response Response To DsRNA Gland Development Immune Response-regulating Cell Surface Receptor Signaling Pathway Transcription Coactivator Binding B Cell Receptor Signaling Pathway Response To Lipid Regulation Of Immune System Process Response To Lipopolysaccharide Regulation Of Defense Response Tumor Necrosis Factor-mediated Signaling Pathway Response To Molecule Of Bacterial Origin Positive Regulation Of MiRNA Metabolic Process Regulation Of Interleukin-12 Production Negative Regulation Of Cytokine Production RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Immune Response-activating Signaling Pathway Positive Regulation Of DNA-templated Transcription Initiation Intracellular Signal Transduction
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