RIPK4 and PADI2

Number of citations: 83 (PubMedID 35914814)
Data Source: BioGRID (two hybrid)

		RIPK4	PADI2
Name		receptor interacting serine/threonine kinase 4	peptidyl arginine deiminase 2
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane	Euchromatin Extracellular Region Nucleus Cytoplasm Cytosol Azurophil Granule Lumen Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Protein-arginine Deiminase Activity Calcium Ion Binding Hydrolase Activity Nuclear Estrogen Receptor Binding Protein Homodimerization Activity Metal Ion Binding Histone Arginine Deiminase Activity Histone H3R26 Arginine Deiminase Activity
	Biological Process	Morphogenesis Of An Epithelium Skin Development Positive Regulation Of NF-kappaB Transcription Factor Activity	Chromatin Remodeling Substantia Nigra Development Estrogen Receptor Signaling Pathway Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of Lymphocyte Chemotaxis Cellular Response To Leukemia Inhibitory Factor
Pathways		None	Chromatin modifying enzymes Neutrophil degranulation
Drugs		None	Citrulline
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847 ) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683 )	A body shape index ( 34021172 ) Gut microbiota relative abundance (Ruminococcus belonging to family Lachnospiraceae) ( 33208821 ) Hemoglobin ( 32888494 ) Hip circumference adjusted for BMI ( 34021172 ) Prudent dietary pattern ( 28644415 ) Rheumatoid arthritis ( 30423114 ) Visceral fat ( 30942860 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 )
Novel Interactors		None recorded	2 novel interactors: EMC1 PADI4
Interacting Genes		38 interacting genes: ANK2 ANK3 ANKRD6 ASB3 BIRC2 BIRC3 BTRC CARS2 CLTC CTBP1 FBXW11 GPSM3 HSPA5 KPNA1 LINC01537 MACF1 MAGI2 MIB1 MICU1 MTPN MYO1E NAPA PADI2 PREPL PRKCB PRKCD PTPRK RPL13 SPAG8 SPAST STAM TNPO2 TRAF7 UBE4B VCP VWC2L WDR19 XIAP	1 interacting genes: RIPK4
Entrez ID		54101	11240
HPRD ID		10419	06396
Ensembl ID		ENSG00000183421	ENSG00000117115
Uniprot IDs		Q96T11 Q9H4D1	Q9Y2J8
PDB IDs		Not available	4N20 4N22 4N24 4N25 4N26 4N28 4N2A 4N2B 4N2C 4N2D 4N2E 4N2F 4N2G 4N2H 4N2I 4N2K 4N2L 4N2M 4N2N 9B96 9B97 9B98
GO Terms Enriched among Interactors		Cytoplasm Canonical NF-kappaB Signal Transduction Cellular Localization Signal Transduction Vesicle-mediated Transport Intracellular Protein Localization Protein Transport Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein Ubiquitination Post-translational Protein Modification Positive Regulation Of Post-translational Protein Modification Intracellular Signaling Cassette Establishment Of Protein Localization Ubiquitin Protein Ligase Activity Mitotic Spindle Disassembly Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Modification Process Protein Kinase C Signaling Golgi Vesicle Transport Protein Polyubiquitination Intracellular Transport Regulation Of Cell Communication Non-canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Protein Localization To Membrane Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Golgi To Plasma Membrane Protein Transport Regulation Of Canonical NF-kappaB Signal Transduction Intracellular Signal Transduction Regulation Of Wnt Signaling Pathway Establishment Of Localization In Cell Positive Regulation Of Protein Ubiquitination Channel Activator Activity Proteolysis Involved In Protein Catabolic Process Protein Localization To Cell Periphery Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Intracellular Protein Transport Negative Regulation Of Signal Transduction Regulation Of Post-translational Protein Modification Cytosol Ubiquitin-dependent Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Modification-dependent Protein Catabolic Process Cytoskeleton Positive Regulation Of Membrane Potential Establishment Of Protein Localization To Plasma Membrane	Histone H3R8 Arginine Deiminase Activity Histone H3R17 Arginine Deiminase Activity Histone H3R2 Arginine Deiminase Activity Histone H3R26 Arginine Deiminase Activity Histone Arginine Deiminase Activity Protein-arginine Deiminase Activity Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence EMC Complex Membrane Insertase Activity Tail-anchored Membrane Protein Insertion Into ER Membrane Protein Insertion Into ER Membrane Protein-containing Complex