MAVS and TICAM1

Number of citations of the paper that reports this interaction (PMID 16153868)
390

Data Source:
HPRD (in vitro, in vivo)

		MAVS	TICAM1
Gene Name		mitochondrial antiviral signaling protein	toll-like receptor adaptor molecule 1
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Peroxisomal Membrane Integral Component Of Membrane Mitochondrial Membrane	Cytosol Endosome Membrane Ripoptosome
	Molecular Function	Signal Transducer Activity Protein Binding Protein Kinase Binding CARD Domain Binding	Signal Transducer Activity Protein Binding Protein Kinase Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Signal Transduction Viral Process Negative Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Protein Import Into Nucleus, Translocation RIG-I Signaling Pathway Defense Response To Bacterium Positive Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Exogenous DsRNA Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of IP-10 Production Regulation Of Peroxisome Organization	Toll-like Receptor Signaling Pathway Macrophage Activation Involved In Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Protein Binding Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Regulation Of Protein Homodimerization Activity Positive Regulation Of Chemokine Biosynthetic Process Innate Immune Response Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Apoptotic Signaling Pathway
Pathways		TRAF3-dependent IRF activation pathway RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Innate Immune System	TRAF6 mediated induction of TAK1 complex TRIF-mediated TLR3/TLR4 signaling IKK complex recruitment mediated by RIP1 Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade RIP-mediated NFkB activation via ZBP1 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Activated TLR4 signalling Toll-Like Receptors Cascades ZBP1(DAI) mediated induction of type I IFNs Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade TRIF-mediated programmed cell death Innate Immune System
Drugs
Diseases
GWAS			Vitiligo ( 22561518)
Protein-Protein Interactions		19 interactors: ABL1 BAG6 CALCOCO2 DDX58 IRF3 IRF5 IRF7 KCNIP3 MAP3K7 OAS3 RIPK2 RNF5 SMURF2 STAT1 TBK1 TICAM1 TRAF5 TRAF6 UBE4A	23 interactors: AZI2 IKBKE IRF3 IRF7 MAVS PIAS4 PIK3CA RIPK1 RIPK3 SRSF4 TBK1 TICAM2 TIRAP TLR2 TLR3 TNFAIP3 TRAF1 TRAF2 TRAF3 TRAF4 TRAF6 TRAM1 UBQLN1
Entrez ID		57506	148022
HPRD ID		13847	06350
Ensembl ID			ENSG00000127666
Uniprot IDs		M1P2Z0 Q7Z434	Q8IUC6
PDB IDs		2VGQ	3RC4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Interferon-beta Production Regulation Of Interferon-beta Production Positive Regulation Of Interferon-alpha Production Innate Immune Response Response To Other Organism Response To Biotic Stimulus TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Cytokine Production Regulation Of I-kappaB Kinase/NF-kappaB Signaling MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Type I Interferon Production Regulation Of Innate Immune Response Activation Of Innate Immune Response Defense Response To Virus Toll-like Receptor 4 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Immune Response Regulation Of Type I Interferon Production Defense Response Toll-like Receptor Signaling Pathway Regulation Of Cytokine Production Response To Virus Immune System Process Response To Stress Immune Response-regulating Signaling Pathway Response To Bacterium Response To Organic Substance Response To Exogenous DsRNA Regulation Of Immune Response Positive Regulation Of Immune Response I-kappaB Kinase/NF-kappaB Signaling Apoptotic Process Response To External Stimulus Programmed Cell Death Cellular Response To Lipopolysaccharide Cellular Response To Organic Substance Response To DsRNA Cell Death Cellular Response To Molecule Of Bacterial Origin Death Response To Interferon-gamma Response To Molecule Of Bacterial Origin Regulation Of Gene Expression Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus Intracellular Receptor Signaling Pathway Positive Regulation Of Immune System Process	Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Regulation Of Type I Interferon Production TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response-regulating Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Immune Response Regulation Of Cytokine Production Innate Immune Response Regulation Of Immune Response Regulation Of Interferon-beta Production Positive Regulation Of Immune System Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cytokine Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Immune System Process Immune Response Positive Regulation Of Intracellular Signal Transduction Defense Response Positive Regulation Of Type I Interferon Production Immune System Process Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Interferon-beta Production Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity NIK/NF-kappaB Signaling Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Type I Interferon Production Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Interferon-alpha Production Negative Regulation Of Cytokine Production Cellular Response To Stimulus Positive Regulation Of Protein Metabolic Process Signaling Cell Communication Apoptotic Process Programmed Cell Death
Tagcloud ?		2b 2c 3c 3cpro adaptors asp classic cleavage comprises conducts cys evasion genera glu innate irf3 irf7 livestock nemo p1 p2 picornavirus polyproteins preference triad trif vp1 vp2 vp3	alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hist3h3 hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest
Tagcloud (Difference) ?		2b 2c 3c 3cpro adaptors asp classic cleavage comprises conducts cys evasion genera glu irf3 irf7 livestock nemo p1 p2 picornavirus polyproteins preference triad trif vp1 vp2 vp3	alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hist3h3 hypotheses hypothetical icsnpathway il27ra modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest
Tagcloud (Intersection) ?		innate