MAVS and TRIM31

Number of citations of the paper that reports this interaction (PubMedID 37582970)
38

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study)

		MAVS	TRIM31
Description		mitochondrial antiviral signaling protein	tripartite motif containing 31
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Mitochondrion Mitochondrial Outer Membrane Peroxisome Peroxisomal Membrane Membrane Mitochondrial Membrane	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Signaling Adaptor Activity Identical Protein Binding CARD Domain Binding Molecular Adaptor Activity Protein Serine/threonine Kinase Binding DNA-binding Transcription Factor Binding Molecular Condensate Scaffold Activity	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Immune System Process Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway Signal Transduction MRNA Transcription Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction NLRP3 Inflammasome Complex Assembly Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Protein Localization To Mitochondrion Cellular Response To Exogenous DsRNA Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of IP-10 Production Antiviral Innate Immune Response Regulation Of Peroxisome Organization Positive Regulation Of NLRP3 Inflammasome Complex Assembly	Immune System Process Ubiquitin-dependent Protein Catabolic Process Inflammatory Response Protein Ubiquitination Viral Release From Host Cell Negative Regulation Of Viral Transcription NLRP3 Inflammasome Complex Assembly Innate Immune Response Positive Regulation Of DNA-templated Transcription Host-mediated Suppression Of Symbiont Invasion Defense Response To Virus Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Antiviral Innate Immune Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly
Pathways		DDX58/IFIH1-mediated induction of interferon-alpha/beta Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses PKR-mediated signaling	Interferon gamma signaling
Drugs
Diseases
GWAS		Platelet distribution width ( 32888494)	Anger ( 24489884) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Beta-2 microglubulin plasma levels ( 23417110) Chronic obstructive pulmonary disease ( 33909500) Estimated glomerular filtration rate in diabetes ( 31451708) Haemorrhoidal disease ( 33888516) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Isovolumetric relaxation time ( 28394258) Low density lipoprotein cholesterol levels ( 32154731) Mean corpuscular hemoglobin ( 27863252) Neuroticism ( 29255261) Prostate cancer ( 25217961) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systemic lupus erythematosus ( 32771030) Takayasu arteritis ( 33308445) Type 1 diabetes and autoimmune thyroid diseases ( 25936594)
Interacting Genes		32 interacting genes: ABL1 CCDC50 CNTN1 DDX3X EIF2AK2 IKBKB IRF3 IRF5 IRF7 KCNIP3 MAP1LC3A MAP3K7 OAS3 OTUD4 RIGI RIPK2 RNF115 RNF125 RNF135 RNF34 SMURF2 STAT1 TBK1 TICAM1 TNKS TNKS2 TRAF3 TRAF6 TRIM31 UBC UBE4A USP25	26 interacting genes: CCT6A CFLAR EID3 IKBKG MAGEA1 MAGEA2B MAVS MKRN3 MNAT1 NSMCE4A RHBDF2 SYK TRAF2 TRIM23 TRIM27 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2K UBE2L3 UBE2N UBE2W USP7 ZSCAN1
Entrez ID		57506	11074
HPRD ID		13847	10281
Ensembl ID		ENSG00000088888	ENSG00000204616
Uniprot IDs		Q7Z434	Q2L6J1 Q9BZY9
PDB IDs		2MS7 2MS8 2VGQ 3J6C 3J6J 3RC5 4P4H 4Z8M 5JEK 7DNI 8WKW	2YSJ 2YSL
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Type I Interferon Production Pattern Recognition Receptor Signaling Pathway Regulation Of Type I Interferon Production Innate Immune Response-activating Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Activation Of Innate Immune Response Immune Response-activating Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Interferon-beta Production Positive Regulation Of Interferon-beta Production Immune Response-regulating Signaling Pathway Activation Of Immune Response Intracellular Receptor Signaling Pathway Response To Virus Regulation Of Defense Response Positive Regulation Of Defense Response Defense Response To Virus Positive Regulation Of Interferon-alpha Production Antiviral Innate Immune Response Positive Regulation Of Cytokine Production Regulation Of Immune Response Positive Regulation Of Immune Response Regulation Of Cytokine Production Protein Polyubiquitination Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Innate Immune Response Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Defense Response To Symbiont MyD88-independent Toll-like Receptor Signaling Pathway Protein Ubiquitination Defense Response To Other Organism Response To Other Organism Response To External Biotic Stimulus Regulation Of Immune System Process Immune Response Protein Modification By Small Protein Conjugation Immune System Process Positive Regulation Of Immune System Process Defense Response Protein Modification Process Cytokine-mediated Signaling Pathway Post-translational Protein Modification Positive Regulation Of Gene Expression Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cytosol	Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Polyubiquitination Post-translational Protein Modification Protein Ubiquitination Protein Modification Process TORC1 Signaling Protein Metabolic Process TOR Signaling Protein K11-linked Ubiquitination Protein K48-linked Ubiquitination Transferase Activity Negative Regulation Of TORC1 Signaling Protein K63-linked Ubiquitination Macromolecule Metabolic Process Negative Regulation Of TOR Signaling Ubiquitin Protein Ligase Binding Regulation Of TORC1 Signaling Ubiquitin Ligase Complex Regulation Of Metabolic Process Ubiquitin Protein Ligase Activity Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Modification-dependent Protein Catabolic Process DNA Damage Response Macromolecule Catabolic Process Regulation Of TOR Signaling ATP Binding Nucleotide Binding Innate Immune Response Regulation Of Nucleobase-containing Compound Metabolic Process Proteolysis Involved In Protein Catabolic Process Proteolysis Positive Regulation Of Autophagy Regulation Of Macromolecule Metabolic Process Regulation Of DNA-binding Transcription Factor Activity DNA Repair Cellular Response To Stress Defense Response To Symbiont Defense Response To Other Organism Response To Stress Nucleus Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Metabolic Process Regulation Of Telomere Maintenance Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Establishment Of Protein Localization To Telomere
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