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MAVS and OAS3
Number of citations of the paper that reports this interaction (PubMedID
21903422
)
55
Data Source:
BioGRID
(pull down)
MAVS
OAS3
Description
mitochondrial antiviral signaling protein
2'-5'-oligoadenylate synthetase 3
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Mitochondrion
Mitochondrial Outer Membrane
Peroxisome
Peroxisomal Membrane
Membrane
Mitochondrial Membrane
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Intracellular Membrane-bounded Organelle
Molecular Function
Protein Binding
Protein Kinase Binding
Protein-macromolecule Adaptor Activity
Signaling Adaptor Activity
Identical Protein Binding
CARD Domain Binding
Molecular Adaptor Activity
Protein Serine/threonine Kinase Binding
DNA-binding Transcription Factor Binding
Molecular Condensate Scaffold Activity
Nucleotide Binding
2'-5'-oligoadenylate Synthetase Activity
RNA Binding
Double-stranded RNA Binding
Protein Binding
ATP Binding
Transferase Activity
Nucleotidyltransferase Activity
Metal Ion Binding
Biological Process
Activation Of Innate Immune Response
Positive Regulation Of Defense Response To Virus By Host
Immune System Process
Positive Regulation Of Myeloid Dendritic Cell Cytokine Production
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Signal Transduction
MRNA Transcription
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Intracellular Signal Transduction
Positive Regulation Of Protein Import Into Nucleus
Defense Response To Bacterium
Positive Regulation Of Canonical NF-kappaB Signal Transduction
NLRP3 Inflammasome Complex Assembly
Negative Regulation Of Viral Genome Replication
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Defense Response To Virus
Type I Interferon-mediated Signaling Pathway
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Positive Regulation Of Response To Cytokine Stimulus
Protein Localization To Mitochondrion
Cellular Response To Exogenous DsRNA
Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production
Positive Regulation Of IP-10 Production
Antiviral Innate Immune Response
Regulation Of Peroxisome Organization
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Immune System Process
Nucleobase-containing Compound Metabolic Process
Response To Virus
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Chemokine (C-X-C Motif) Ligand 9 Production
RIG-I Signaling Pathway
MDA-5 Signaling Pathway
Defense Response To Bacterium
Negative Regulation Of Viral Genome Replication
Innate Immune Response
Defense Response To Virus
Type I Interferon-mediated Signaling Pathway
Negative Regulation Of Type I Interferon-mediated Signaling Pathway
Regulation Of Ribonuclease Activity
Interleukin-27-mediated Signaling Pathway
Cellular Response To Exogenous DsRNA
Positive Regulation Of Monocyte Chemotactic Protein-1 Production
Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production
Negative Regulation Of IP-10 Production
Defense Response To Other Organism
Antiviral Innate Immune Response
Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Ovarian tumor domain proteases
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Negative regulators of DDX58/IFIH1 signaling
Negative regulators of DDX58/IFIH1 signaling
SARS-CoV-1 activates/modulates innate immune responses
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Evasion by RSV of host interferon responses
PKR-mediated signaling
Interferon gamma signaling
OAS antiviral response
Interferon alpha/beta signaling
Drugs
Diseases
GWAS
Platelet distribution width (
32888494
)
Alcohol consumption (
21270382
)
Alcohol consumption (drinkers vs non-drinkers) (
28485404
)
Body mass index (
26426971
)
Chronic lymphocytic leukemia (
28165464
)
HDL cholesterol (
21909109
)
High density lipoprotein cholesterol levels (
30718733
)
Hypertension (
32709000
)
Low HDL-cholesterol levels (
31006500
)
Myocardial infarction (
30226566
)
Response to fenofibrate (adiponectin levels) (
23149075
)
Right-sided colonic diverticulosis (
31089239
)
Interacting Genes
32 interacting genes:
ABL1
CCDC50
CNTN1
DDX3X
EIF2AK2
IKBKB
IRF3
IRF5
IRF7
KCNIP3
MAP1LC3A
MAP3K7
OAS3
OTUD4
RIGI
RIPK2
RNF115
RNF125
RNF135
RNF34
SMURF2
STAT1
TBK1
TICAM1
TNKS
TNKS2
TRAF3
TRAF6
TRIM31
UBC
UBE4A
USP25
6 interacting genes:
DHX30
EIF6
FTSJ3
IFRD2
MAVS
RNF10
Entrez ID
57506
4940
HPRD ID
13847
04519
Ensembl ID
ENSG00000088888
ENSG00000111331
Uniprot IDs
Q7Z434
A0A7P0T8S7
Q9Y6K5
PDB IDs
2MS7
2MS8
2VGQ
3J6C
3J6J
3RC5
4P4H
4Z8M
5JEK
7DNI
8WKW
4S3N
Enriched GO Terms of Interacting Partners
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Positive Regulation Of Type I Interferon Production
Pattern Recognition Receptor Signaling Pathway
Regulation Of Type I Interferon Production
Innate Immune Response-activating Signaling Pathway
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Activation Of Innate Immune Response
Immune Response-activating Signaling Pathway
Regulation Of Innate Immune Response
Positive Regulation Of Innate Immune Response
Regulation Of Interferon-beta Production
Positive Regulation Of Interferon-beta Production
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Intracellular Receptor Signaling Pathway
Response To Virus
Regulation Of Defense Response
Positive Regulation Of Defense Response
Defense Response To Virus
Positive Regulation Of Interferon-alpha Production
Antiviral Innate Immune Response
Positive Regulation Of Cytokine Production
Regulation Of Immune Response
Positive Regulation Of Immune Response
Regulation Of Cytokine Production
Protein Polyubiquitination
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Innate Immune Response
Toll-like Receptor 4 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Cell Surface Toll-like Receptor Signaling Pathway
Cell Surface Pattern Recognition Receptor Signaling Pathway
Defense Response To Symbiont
MyD88-independent Toll-like Receptor Signaling Pathway
Protein Ubiquitination
Defense Response To Other Organism
Response To Other Organism
Response To External Biotic Stimulus
Regulation Of Immune System Process
Immune Response
Protein Modification By Small Protein Conjugation
Immune System Process
Positive Regulation Of Immune System Process
Defense Response
Protein Modification Process
Cytokine-mediated Signaling Pathway
Post-translational Protein Modification
Positive Regulation Of Gene Expression
Immune Response-activating Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Cytosol
Maturation Of 5.8S RRNA
Ribonucleoprotein Complex Biogenesis
Ribosome Biogenesis
Maturation Of LSU-rRNA
Assembly Of Large Subunit Precursor Of Preribosome
Ribosome Binding
Positive Regulation Of IP-10 Production
Regulation Of Peroxisome Organization
RNA 2'-O-methyltransferase Activity
RRNA (uridine-2'-O-)-methyltransferase Activity
Lamin Filament
Cytosolic Ribosome Assembly
Negative Regulation Of Translation
Postsynapse To Nucleus Signaling Pathway
Extrinsic Component Of Postsynaptic Density Membrane
Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
RRNA (guanine) Methyltransferase Activity
RRNA Methyltransferase Activity
RRNA Processing
Protein-RNA Complex Assembly
Mitochondrial Large Ribosomal Subunit Assembly
Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production
Positive Regulation Of Myeloid Dendritic Cell Cytokine Production
Negative Regulation Of Schwann Cell Proliferation
G-quadruplex RNA Binding
RRNA Metabolic Process
Ribosome-associated Ubiquitin-dependent Protein Catabolic Process
Ribosomal Subunit Export From Nucleus
Positive Regulation Of Dendritic Cell Cytokine Production
Preribosome, Small Subunit Precursor
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Tagcloud (Intersection)
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