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MAVS and RNF34
Number of citations of the paper that reports this interaction (PubMedID
31304625
)
65
Data Source:
BioGRID
(pull down, far western blotting)
MAVS
RNF34
Description
mitochondrial antiviral signaling protein
ring finger protein 34
Image
No pdb structure
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Mitochondrion
Mitochondrial Outer Membrane
Peroxisome
Peroxisomal Membrane
Membrane
Mitochondrial Membrane
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Endomembrane System
Membrane
Nuclear Body
Nuclear Speck
Molecular Function
Protein Binding
Protein Kinase Binding
Protein-macromolecule Adaptor Activity
Signaling Adaptor Activity
Identical Protein Binding
CARD Domain Binding
Molecular Adaptor Activity
Protein Serine/threonine Kinase Binding
DNA-binding Transcription Factor Binding
Molecular Condensate Scaffold Activity
P53 Binding
Protein Binding
Zinc Ion Binding
Transferase Activity
Ubiquitin Protein Ligase Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Phosphatidylinositol Phosphate Binding
Biological Process
Activation Of Innate Immune Response
Positive Regulation Of Defense Response To Virus By Host
Immune System Process
Positive Regulation Of Myeloid Dendritic Cell Cytokine Production
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Signal Transduction
MRNA Transcription
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Intracellular Signal Transduction
Positive Regulation Of Protein Import Into Nucleus
Defense Response To Bacterium
Positive Regulation Of Canonical NF-kappaB Signal Transduction
NLRP3 Inflammasome Complex Assembly
Negative Regulation Of Viral Genome Replication
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Defense Response To Virus
Type I Interferon-mediated Signaling Pathway
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Positive Regulation Of Response To Cytokine Stimulus
Protein Localization To Mitochondrion
Cellular Response To Exogenous DsRNA
Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production
Positive Regulation Of IP-10 Production
Antiviral Innate Immune Response
Regulation Of Peroxisome Organization
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Protein Ubiquitination
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Cold
Protein K48-linked Ubiquitination
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Oxygen Metabolic Process
Pathways
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Ovarian tumor domain proteases
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Negative regulators of DDX58/IFIH1 signaling
Negative regulators of DDX58/IFIH1 signaling
SARS-CoV-1 activates/modulates innate immune responses
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Evasion by RSV of host interferon responses
PKR-mediated signaling
Regulation of TP53 Degradation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Platelet distribution width (
32888494
)
Interacting Genes
32 interacting genes:
ABL1
CCDC50
CNTN1
DDX3X
EIF2AK2
IKBKB
IRF3
IRF5
IRF7
KCNIP3
MAP1LC3A
MAP3K7
OAS3
OTUD4
RIGI
RIPK2
RNF115
RNF125
RNF135
RNF34
SMURF2
STAT1
TBK1
TICAM1
TNKS
TNKS2
TRAF3
TRAF6
TRIM31
UBC
UBE4A
USP25
17 interacting genes:
APP
APPBP2
DNAJA3
FLII
IKBKG
MAVS
MKS1
NOD1
PHF7
RUBCN
TRIM23
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2F
UBE2H
Entrez ID
57506
80196
HPRD ID
13847
10509
Ensembl ID
ENSG00000088888
ENSG00000170633
Uniprot IDs
Q7Z434
A0A087WTM5
Q969K3
PDB IDs
2MS7
2MS8
2VGQ
3J6C
3J6J
3RC5
4P4H
4Z8M
5JEK
7DNI
8WKW
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Type I Interferon Production
Pattern Recognition Receptor Signaling Pathway
Regulation Of Type I Interferon Production
Innate Immune Response-activating Signaling Pathway
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Activation Of Innate Immune Response
Immune Response-activating Signaling Pathway
Regulation Of Innate Immune Response
Positive Regulation Of Innate Immune Response
Regulation Of Interferon-beta Production
Positive Regulation Of Interferon-beta Production
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Intracellular Receptor Signaling Pathway
Response To Virus
Regulation Of Defense Response
Positive Regulation Of Defense Response
Defense Response To Virus
Positive Regulation Of Interferon-alpha Production
Antiviral Innate Immune Response
Positive Regulation Of Cytokine Production
Regulation Of Immune Response
Positive Regulation Of Immune Response
Regulation Of Cytokine Production
Protein Polyubiquitination
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Innate Immune Response
Toll-like Receptor 4 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Cell Surface Toll-like Receptor Signaling Pathway
Cell Surface Pattern Recognition Receptor Signaling Pathway
Defense Response To Symbiont
MyD88-independent Toll-like Receptor Signaling Pathway
Protein Ubiquitination
Defense Response To Other Organism
Response To Other Organism
Response To External Biotic Stimulus
Regulation Of Immune System Process
Immune Response
Protein Modification By Small Protein Conjugation
Immune System Process
Positive Regulation Of Immune System Process
Defense Response
Protein Modification Process
Cytokine-mediated Signaling Pathway
Post-translational Protein Modification
Positive Regulation Of Gene Expression
Immune Response-activating Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Cytosol
Ubiquitin Conjugating Enzyme Activity
Protein K48-linked Ubiquitination
Protein Modification By Small Protein Conjugation
Ubiquitin-protein Transferase Activity
Post-translational Protein Modification
Modification-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Proteolysis Involved In Protein Catabolic Process
Protein Polyubiquitination
Innate Immune Response
Cytosol
ATP Binding
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Catabolic Process
Macromolecule Catabolic Process
Defense Response To Symbiont
Defense Response To Other Organism
Protein Modification Process
Proteasomal Protein Catabolic Process
Proteolysis
CARD Domain Binding
Positive Regulation Of Interleukin-6 Production
Nucleotide Binding
Transferase Activity
Positive Regulation Of Tumor Necrosis Factor Production
Ubiquitin Ligase Complex
Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production
Defense Response To Bacterium
Immune System Process
Protein Serine/threonine Kinase Binding
Regulation Of Canonical NF-kappaB Signal Transduction
Protein Catabolic Process
Ubiquitin Protein Ligase Activity
Regulation Of Autophagy
Regulation Of Interleukin-6 Production
Response To Other Organism
Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Response To Bacterium
Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response
Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Autophagy
Immune Response
Protein K11-linked Ubiquitination
Protein Metabolic Process
Regulation Of Innate Immune Response
Amyloid-beta Complex
Growth Cone Lamellipodium
Regulation Of Response To Calcium Ion
Amylin Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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