MAVS and MAP3K7

Number of citations of the paper that reports this interaction (PubMedID 16153868)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		MAVS	MAP3K7
Description		mitochondrial antiviral signaling protein	mitogen-activated protein kinase kinase kinase 7
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Mitochondrion Mitochondrial Outer Membrane Peroxisome Peroxisomal Membrane Membrane Mitochondrial Membrane	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Endosome Membrane Membrane ATAC Complex
	Molecular Function	Protein Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Signaling Adaptor Activity Identical Protein Binding CARD Domain Binding Molecular Adaptor Activity Protein Serine/threonine Kinase Binding DNA-binding Transcription Factor Binding Molecular Condensate Scaffold Activity	Nucleotide Binding Magnesium Ion Binding Transcription Coactivator Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity MAP Kinase Kinase Kinase Activity Signaling Receptor Binding Type II Transforming Growth Factor Beta Receptor Binding Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Kinase Activity Transferase Activity Protein Kinase Binding Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Binding Histone Kinase Activity Identical Protein Binding Metal Ion Binding Scaffold Protein Binding Protein Serine Kinase Activity Protein Serine/threonine Kinase Binding DNA-binding Transcription Factor Binding Linear Polyubiquitin Binding
	Biological Process	Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Immune System Process Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway Signal Transduction MRNA Transcription Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction NLRP3 Inflammasome Complex Assembly Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Protein Localization To Mitochondrion Cellular Response To Exogenous DsRNA Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of IP-10 Production Antiviral Innate Immune Response Regulation Of Peroxisome Organization Positive Regulation Of NLRP3 Inflammasome Complex Assembly	MAPK Cascade Response To Hypoxia Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of T Cell Cytokine Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Chromatin Remodeling Apoptotic Process Inflammatory Response Immune Response Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction I-kappaB Phosphorylation JNK Cascade Positive Regulation Of Metabolic Process Positive Regulation Of Autophagy Negative Regulation Of Gene Expression Positive Regulation Of Macroautophagy Signal Transduction Involved In Regulation Of Gene Expression SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Type I Interferon Production Protein Exit From Endoplasmic Reticulum Positive Regulation Of Interleukin-2 Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Non-canonical NF-kappaB Signal Transduction P38MAPK Cascade Fc-epsilon Receptor Signaling Pathway Interleukin-33-mediated Signaling Pathway Interleukin-17A-mediated Signaling Pathway Defense Response To Bacterium Signal Transduction In Response To DNA Damage Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Anoikis Positive Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Positive Regulation Of Cell Cycle Positive Regulation Of Cell Size T Cell Receptor Signaling Pathway Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Transforming Growth Factor Beta Stimulus CGAS/STING Signaling Pathway Positive Regulation Of CGAS/STING Signaling Pathway Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Cellular Response To Angiotensin Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Response To Angiotensin
Pathways		DDX58/IFIH1-mediated induction of interferon-alpha/beta Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses PKR-mediated signaling	Activation of NF-kappaB in B cells NOD1/2 Signaling Pathway Downstream TCR signaling FCERI mediated NF-kB activation Ca2+ pathway TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NF-kappa-B signaling pathway CLEC7A (Dectin-1) signaling Ub-specific processing proteases TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway SARS-CoV-2 activates/modulates innate and adaptive immune responses IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS		Platelet distribution width ( 32888494)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asthma ( 29273806 31959851) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Bone mineral density (hip) ( 30172743) Celiac disease ( 20190752) Cortical surface area ( 32963231) Cortical volume ( 32963231) Graves' disease ( 21841780) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		32 interacting genes: ABL1 CCDC50 CNTN1 DDX3X EIF2AK2 IKBKB IRF3 IRF5 IRF7 KCNIP3 MAP1LC3A MAP3K7 OAS3 OTUD4 RIGI RIPK2 RNF115 RNF125 RNF135 RNF34 SMURF2 STAT1 TBK1 TICAM1 TNKS TNKS2 TRAF3 TRAF6 TRIM31 UBC UBE4A USP25	73 interacting genes: AKTIP BBS10 BCL10 CALML6 CAMK2G CARD11 CHUK COPS5 CYLD EIF2AK2 ELP1 EZH2 FOS GPR25 HGS HIPK2 IKBKB IL17RD IRAK1 MAILR MAP2K4 MAP2K6 MAP3K14 MAP3K3 MAP3K5 MAP4K1 MAP4K4 MAPK14 MAPK6 MAPK8 MAPK8IP1 MAVS MUL1 NAIP NDUFS6 NFKBIA NOD2 NRIP1 PEBP1 PELI3 PINK1 PPM1B PPM1L PPP2R1A PPP5C PRKAB1 RBX1 RELA RNF19A ROR2 SMAD3 SMAD6 SMAD7 STAT3 STRADB SUPT20H TAB1 TAB2 TGFBR1 TNFAIP8L2 TNFRSF11A TRAF3 TRAF3IP2 TRAF6 UBASH3A UBC USP29 USP4 USP8 VRK2 XIAP ZNF593 ZNF746
Entrez ID		57506	6885
HPRD ID		13847	04011
Ensembl ID		ENSG00000088888	ENSG00000135341
Uniprot IDs		Q7Z434	O43318
PDB IDs		2MS7 2MS8 2VGQ 3J6C 3J6J 3RC5 4P4H 4Z8M 5JEK 7DNI 8WKW	2EVA 2YIY 4GS6 4L3P 4L52 4L53 4O91 5E7R 5GJD 5GJF 5GJG 5J7S 5J8I 5J9L 5JGA 5JGB 5JGD 5JH6 5JK3 5V5N 7NTH 7NTI 8GW3 9FPD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Type I Interferon Production Pattern Recognition Receptor Signaling Pathway Regulation Of Type I Interferon Production Innate Immune Response-activating Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Activation Of Innate Immune Response Immune Response-activating Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Interferon-beta Production Positive Regulation Of Interferon-beta Production Immune Response-regulating Signaling Pathway Activation Of Immune Response Intracellular Receptor Signaling Pathway Response To Virus Regulation Of Defense Response Positive Regulation Of Defense Response Defense Response To Virus Positive Regulation Of Interferon-alpha Production Antiviral Innate Immune Response Positive Regulation Of Cytokine Production Regulation Of Immune Response Positive Regulation Of Immune Response Regulation Of Cytokine Production Protein Polyubiquitination Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Innate Immune Response Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Defense Response To Symbiont MyD88-independent Toll-like Receptor Signaling Pathway Protein Ubiquitination Defense Response To Other Organism Response To Other Organism Response To External Biotic Stimulus Regulation Of Immune System Process Immune Response Protein Modification By Small Protein Conjugation Immune System Process Positive Regulation Of Immune System Process Defense Response Protein Modification Process Cytokine-mediated Signaling Pathway Post-translational Protein Modification Positive Regulation Of Gene Expression Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cytosol	Intracellular Signaling Cassette Intracellular Signal Transduction MAPK Cascade Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Canonical NF-kappaB Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Signal Transduction Signal Transduction Innate Immune Response-activating Signaling Pathway Protein Kinase Activity Regulation Of Cytokine Production Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Serine/threonine Kinase Activity Non-canonical NF-kappaB Signal Transduction Activation Of Innate Immune Response Protein Modification Process Regulation Of Defense Response Negative Regulation Of Intracellular Signal Transduction Protein Serine Kinase Activity Positive Regulation Of Innate Immune Response Response To Stress Regulation Of MAPK Cascade Negative Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasm Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Defense Response Regulation Of Immune Response Regulation Of DNA-binding Transcription Factor Activity Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of JNK Cascade Immune Response-regulating Signaling Pathway Cytosol Regulation Of Apoptotic Process Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Innate Immune Response Regulation Of Immune System Process Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Transferase Activity
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