PLSCR4 and EFEMP2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PLSCR4	EFEMP2
Gene Name		phospholipid scramblase 4	EGF containing fibulin-like extracellular matrix protein 2
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Extracellular Region Basement Membrane Plasma Membrane Vesicle Extracellular Vesicular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding SH3 Domain Binding Phospholipid Scramblase Activity Enzyme Binding CD4 Receptor Binding	Transmembrane Signaling Receptor Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding
	Biological Process	Phospholipid Scrambling Cellular Response To Lipopolysaccharide	Signal Transduction Blood Coagulation Extracellular Matrix Organization
Pathways			Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: EFEMP2 HOXA1 KRTAP4-12 MTUS2 NOTCH2NL PLSCR1 TRIP13	50 interactors: APEX2 AQP1 ATN1 ATXN1 ATXN7 BAG6 C5orf24 CACNA1A CATSPER1 CCDC33 CCND3 CCNK COL8A1 CREB5 DGCR6 FAM107A FAM124B FAM74A4 GFI1B GLRX3 HDAC4 HHEX HOXA1 IL16 LCE2D LCE3C LINGO1 MEOX2 NEDD4L NOS3 NUFIP2 PIDD1 PLSCR1 PLSCR4 PTGER3 RBPMS RERE RHOXF2 RHPN1 RIBC2 SGTA SGTB STK16 TCAF1 TP53 UBQLN1 UBQLN4 ZNF263 ZNF426 ZNF638
Entrez ID		57088	30008
HPRD ID		07401	05221
Ensembl ID		ENSG00000114698	ENSG00000172638
Uniprot IDs		E9PHR9 Q9NRQ2	O95967 Q9H3D5
PDB IDs		3Q5U	2KL7
Enriched GO Terms of Interacting Partners?		Optokinetic Behavior Abducens Nerve Formation Facial Nucleus Development Semicircular Canal Formation Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Rhombomere 4 Development Rhombomere 3 Development Rhombomere 5 Development Phosphatidylserine Biosynthetic Process Embryonic Neurocranium Morphogenesis Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Outer Ear Morphogenesis Phospholipid Scrambling Semicircular Canal Morphogenesis Rhombomere Development Facial Nerve Structural Organization Pons Development Facial Nerve Morphogenesis Female Meiosis I Semicircular Canal Development Blood Coagulation Hemostasis Response To Interferon-beta Parasympathetic Nervous System Development Anatomical Structure Arrangement Synaptonemal Complex Assembly Response To Stimulus Oocyte Maturation Synaptonemal Complex Organization Cochlea Morphogenesis Regulation Of Body Fluid Levels Phosphatidylserine Metabolic Process Wound Healing Male Meiosis I Positive Regulation Of ATPase Activity Motor Neuron Axon Guidance Regulation Of Mast Cell Activation Transcription, DNA-templated Female Meiotic Division Response To Wounding Acute-phase Response RNA Biosynthetic Process Regulation Of ATPase Activity Autonomic Nervous System Development Reciprocal Meiotic Recombination Negative Regulation Of Viral Genome Replication Oocyte Development Oocyte Differentiation Cochlea Development Neural Nucleus Development	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Cellular Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Organ Development Response To Salt Stress Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cell Death Death Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process System Development Developmental Process Phospholipid Scrambling Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Heart Contraction Neuron Death Pons Development Anatomical Structure Development Central Nervous System Development Positive Regulation Of Gene Expression Blood Vessel Development Vasculature Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression
Tagcloud ?		acot2 adiponectin anxa2 asah3l atherogenic brought carry cyp7a1 enpp6 ginseng ginsenosides hfd hmgcs1 il1rn insig1 korean krge lipa mogat1 obesity osbpl3 physiology pla2g4e profoundly saponin slc27a3 sytl4 triglycerides vldlr	acaa1 analogous ap1m2 aspirates cgn combat dcn ddr1 deadly ec ecs endometrial eps8l2 fastkd1 gmip ikbke minimally noncarcinoma p2rx4 p4hb phkg2 ppfibp2 ppp1r16a rassf7 rnf183 sirt6 socs2 tjp3 uterine
Tagcloud (Difference) ?		acot2 adiponectin anxa2 asah3l atherogenic brought carry cyp7a1 enpp6 ginseng ginsenosides hfd hmgcs1 il1rn insig1 korean krge lipa mogat1 obesity osbpl3 physiology pla2g4e profoundly saponin slc27a3 sytl4 triglycerides vldlr	acaa1 analogous ap1m2 aspirates cgn combat dcn ddr1 deadly ec ecs endometrial eps8l2 fastkd1 gmip ikbke minimally noncarcinoma p2rx4 p4hb phkg2 ppfibp2 ppp1r16a rassf7 rnf183 sirt6 socs2 tjp3 uterine
Tagcloud (Intersection) ?