EFEMP2 and RERE

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EFEMP2	RERE
Gene Name		EGF containing fibulin-like extracellular matrix protein 2	arginine-glutamic acid dipeptide (RE) repeats
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Basement Membrane Plasma Membrane Vesicle Extracellular Vesicular Exosome	Histone Deacetylase Complex Nucleus
	Molecular Function	Transmembrane Signaling Receptor Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding	Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Poly-glutamine Tract Binding Zinc Ion Binding Sequence-specific DNA Binding
	Biological Process	Signal Transduction Blood Coagulation Extracellular Matrix Organization	Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated NLS-bearing Protein Import Into Nucleus Multicellular Organismal Development
Pathways		Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS			Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bone mineral density ( 22504420) Vertical cup-disc ratio ( 20548946) Vitiligo ( 20410501)
Protein-Protein Interactions		50 interactors: APEX2 AQP1 ATN1 ATXN1 ATXN7 BAG6 C5orf24 CACNA1A CATSPER1 CCDC33 CCND3 CCNK COL8A1 CREB5 DGCR6 FAM107A FAM124B FAM74A4 GFI1B GLRX3 HDAC4 HHEX HOXA1 IL16 LCE2D LCE3C LINGO1 MEOX2 NEDD4L NOS3 NUFIP2 PIDD1 PLSCR1 PLSCR4 PTGER3 RBPMS RERE RHOXF2 RHPN1 RIBC2 SGTA SGTB STK16 TCAF1 TP53 UBQLN1 UBQLN4 ZNF263 ZNF426 ZNF638	20 interactors: ALG13 ATN1 CBFA2T2 ECM1 EFEMP1 EFEMP2 EHMT2 HIST2H3C KAT6A KRTAP4-12 LZTR1 NR2E1 PLSCR1 PRRC2A PRRC2B PSMA3 RBFOX2 TRIM22 TRIP6 ZMYND8
Entrez ID		30008	473
HPRD ID		05221	05566
Ensembl ID		ENSG00000172638	ENSG00000142599
Uniprot IDs		O95967 Q9H3D5	B1AKN3 Q9P2R6
PDB IDs		2KL7	2YQK
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Cellular Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Organ Development Response To Salt Stress Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cell Death Death Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process System Development Developmental Process Phospholipid Scrambling Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Heart Contraction Neuron Death Pons Development Anatomical Structure Development Central Nervous System Development Positive Regulation Of Gene Expression Blood Vessel Development Vasculature Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression	Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Regulation Of Metabolic Process Gene Expression DNA Methylation On Cytosine Cellular Nitrogen Compound Metabolic Process Regulation Of Cellular Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Transcription, DNA-templated RNA Biosynthetic Process Amygdala Development RNA Metabolic Process DNA Methylation Somatic Stem Cell Maintenance Response To Stress Negative Regulation Of Cell Differentiation Cellular Macromolecule Biosynthetic Process DNA Modification Negative Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity DNA Methylation On Cytosine Within A CG Sequence Blood Coagulation Hemostasis Radial Glia Guided Migration Of Purkinje Cell Regulation Of Definitive Erythrocyte Differentiation Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of Angiogenesis Regulation Of Cell Differentiation Peptidyl-amino Acid Modification Phosphatidylserine Biosynthetic Process Regulation Of Timing Of Neuron Differentiation
Tagcloud ?		acaa1 analogous ap1m2 aspirates cgn combat dcn ddr1 deadly ec ecs endometrial eps8l2 fastkd1 gmip ikbke minimally noncarcinoma p2rx4 p4hb phkg2 ppfibp2 ppp1r16a rassf7 rnf183 sirt6 socs2 tjp3 uterine	antagonism caudal downregulating e8 ectopic embryos exiting extending fgf fgf8 fused h3k27me3 lacz mesoderm neuroectoderm polycomb prc2 ra raldh2 rarb rare rares repress represses repressive somite somites trunk vertebrate
Tagcloud (Difference) ?		acaa1 analogous ap1m2 aspirates cgn combat dcn ddr1 deadly ec ecs endometrial eps8l2 fastkd1 gmip ikbke minimally noncarcinoma p2rx4 p4hb phkg2 ppfibp2 ppp1r16a rassf7 rnf183 sirt6 socs2 tjp3 uterine	antagonism caudal downregulating e8 ectopic embryos exiting extending fgf fgf8 fused h3k27me3 lacz mesoderm neuroectoderm polycomb prc2 ra raldh2 rarb rare rares repress represses repressive somite somites trunk vertebrate
Tagcloud (Intersection) ?