EFEMP2 and DOK7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EFEMP2	DOK7
Description		EGF-like fibulin extracellular matrix protein 2	docking protein 7
Image			No pdb structure
GO Annotations	Cellular Component	Microfibril Extracellular Region Basement Membrane Extracellular Matrix Extracellular Exosome Elastic Fiber Extracellular Vesicle	Nucleoplasm Mitochondrion Plasma Membrane Membrane Neuromuscular Junction Synapse Postsynaptic Membrane
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Heparin Binding Protein Homodimerization Activity	Protein Binding Lipid Binding Protein Kinase Binding Phosphatidylinositol Binding Signaling Adaptor Activity
	Biological Process	Aorta Development Elastic Fiber Assembly Aorta Smooth Muscle Tissue Morphogenesis Artery Development Vascular Associated Smooth Muscle Cell Development Regulation Of Collagen Fibril Organization Positive Regulation Of Collagen Fibril Organization Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Positive Regulation Of Smooth Muscle Cell-matrix Adhesion	Enzyme-linked Receptor Protein Signaling Pathway Neuromuscular Junction Development Positive Regulation Of Rac Protein Signal Transduction Receptor Clustering Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases		Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome	Congenital myasthenic syndrome Fetal akinesia deformation sequence (FADS); Pena-Shokeir syndrome, type 1
GWAS		Acne (severe) ( 24927181) Adult body size ( 32376654) Birth weight ( 31043758) Body size at age 10 ( 32376654) Monocyte count ( 32888494) Retinal detachment or retinal break ( 31816047)	Calcium levels ( 29403010) Coronary artery disease ( 33020668) Fibrinogen levels ( 28107422) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 31562340) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Spondylosis ( 33332786)
Interacting Genes		133 interacting genes: ADAMTSL4 AMMECR1 ANAPC11 AP1M1 APEX2 AQP1 ARRDC3 ATN1 ATXN1 ATXN7 BAG6 C3 C5orf24 CACNA1A CATSPER1 CCDC33 CCND3 CCNK CDPF1 CLPP CNNM3 COL8A1 CREB5 CXCL5 CYSRT1 DGCR6 DOK7 DYRK1A FAM107A FAM110A FAM124B FAM74A4 FAM90A1 FBXW5 FTO FXR1 GFI1B GLRX3 HDAC4 HHEX HHIPL1 HOXA1 HPCAL1 HSD3B7 HSPA12B HSPBP1 IGFBP6 IL16 INCA1 ITGB5 KLF1 KRTAP10-8 KRTAP11-1 KRTAP12-2 KRTAP13-3 KRTAP19-5 KRTAP26-1 KRTAP3-2 LBX1 LCE1A LCE1C LCE1E LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LINGO1 LNX1 MDFI MEOX2 MRPL12 MXI1 NEDD4L NOS3 NR1D2 NTM NUFIP2 OTX1 P2RX7 PIDD1 PITX1 PLSCR1 PLSCR4 PROP1 PRPF31 PRR32 PTGER3 RAB40B RBAK RBP3 RBPMS RERE RHOXF2 RHPN1 RIBC2 RNF138 SGTA SGTB SHANK3 SLC16A5 SLC23A1 SLC25A48 SPACA9 SPATA24 SPATA3 SPATA8 SPRY4 STK16 TCAF1 THAP7 TLE5 TLX3 TP53 TRIB3 TRIM42 UBQLN1 UBQLN4 USP21 ZNF263 ZNF345 ZNF426 ZNF558 ZNF57 ZNF581 ZNF587 ZNF638 ZNF670 ZNF699 ZNF768 ZNF774 ZNF837	8 interacting genes: APPL1 BCAR1 CRK EFEMP2 EFHC1 MPZL1 MUSK YPEL3
Entrez ID		30008	285489
HPRD ID		05221	08744
Ensembl ID		ENSG00000172638	ENSG00000175920
Uniprot IDs		O95967 Q9H3D5	A0A1W2PRA3 A0A2R8Y701 Q18PE1 Q8N1M3
PDB IDs		2KL7
Enriched GO Terms of Interacting Partners?		Protein Binding Keratinization DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Epidermis Development Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Identical Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Regulation Of RNA Metabolic Process CD4 Receptor Binding Regulation Of Primary Metabolic Process Tissue Development Regulation Of Nucleobase-containing Compound Metabolic Process TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Nucleus Sequence-specific Double-stranded DNA Binding Intermediate Filament Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of ERAD Pathway Zinc Ion Binding	Response To Hepatocyte Growth Factor Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Cellular Response To Growth Factor Stimulus Actin Cytoskeleton Response To Growth Factor Positive Regulation Of Protein Geranylgeranylation Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Smooth Muscle Cell-matrix Adhesion Neuromuscular Junction Insulin Receptor Signaling Pathway Helper T Cell Diapedesis Cell Surface Receptor Signaling Pathway Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin Positive Regulation Of Macropinocytosis Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Ruffle SH3 Domain Binding Cerebellar Neuron Development Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Collagen Fibril Organization Regulation Of Smooth Muscle Cell-matrix Adhesion Regulation Of Growth Regulation Of Cellular Component Organization Macropinosome Elastic Fiber Regulation Of Protein Localization To Membrane Aorta Smooth Muscle Tissue Morphogenesis Diapedesis Positive Regulation Of Pinocytosis Cell Chemotaxis Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Receptor Clustering Cellular Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Reelin-mediated Signaling Pathway Response To Endothelin Cellular Response To Endothelin Regulation Of Cell-substrate Adhesion Postsynaptic Specialization Assembly Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Synaptic Assembly At Neuromuscular Junction Endothelin Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Early Phagosome Positive Regulation Of Melanin Biosynthetic Process Protein Kinase B Binding Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
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