PLSCR4 and FCHO1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLSCR4	FCHO1
Description		phospholipid scramblase 4	FCH and mu domain containing endocytic adaptor 1
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GO Annotations	Cellular Component	Nucleus Plasma Membrane Membrane	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin-coated Vesicle Postsynaptic Endocytic Zone
	Molecular Function	Calcium Ion Binding Protein Binding SH3 Domain Binding Phospholipid Scramblase Activity Enzyme Binding CD4 Receptor Binding	Protein Binding AP-2 Adaptor Complex Binding
	Biological Process	Plasma Membrane Phospholipid Scrambling Calcium Activated Phosphatidylserine Scrambling Calcium Activated Phosphatidylcholine Scrambling Cellular Response To Lipopolysaccharide	Endocytosis Clathrin Coat Assembly T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Clathrin-dependent Endocytosis
Pathways			Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Lymphocyte count ( 32888494)	Basophil count ( 32888494) Coronary artery disease ( 29212778) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Monocyte percentage of white cells ( 32888494) Myocardial infarction ( 33532862)
Interacting Genes		63 interacting genes: ABHD17A ADAMTSL4 APLN ATP23 CES1 CFAP68 CLPP CRCT1 DAZAP2 DDIT4L EFEMP2 FCHO1 GATA1 HDHD3 HOXA1 INTS11 ITGB4 KLHL38 KPRP KRT82 KRTAP1-5 KRTAP10-8 KRTAP19-1 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP3-1 KRTAP3-3 KRTAP4-12 KRTAP4-2 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LCE1A LCE1C LCE2B LCE5A LPXN MTUS2 NID2 NOTCH2NLA OXER1 PCSK5 PLA2G10 PLSCR1 RAMAC RBP3 RBPMS RPS27A SLC15A2 SSC4D TEKT5 TENM4 TRIM42 TRIP13 TSPAN4 UBA52 UBB UBC YPEL3 ZNF34	51 interacting genes: ACVR1 APP BYSL CCDC13 CFTR CSNK2A1 CWF19L2 DAB2 DDX6 DNAJC5 ELOA EPS15L1 EXOSC5 FBXL7 GRB7 GUCD1 ITSN1 KAT5 KPRP KRTAP10-1 KRTAP10-5 KRTAP13-2 KRTAP13-4 KRTAP15-1 KRTAP4-12 KRTAP6-1 KRTAP6-3 LGALS14 MAB21L3 NCK1 PCGF1 PHETA1 PHLDA2 PICALM PLAC8 PLSCR4 PRPF3 PRPH PTK6 SH2D4A SMURF1 SRPK2 SYTL4 TCEA2 TCEANC TGFB1 TRIM42 TSPAN4 ZBTB16 ZBTB24 ZNF688
Entrez ID		57088	23149
HPRD ID		07401	16887
Ensembl ID		ENSG00000114698	ENSG00000130475
Uniprot IDs		E9PHR9 Q9NRQ2	A0A0C3SFZ9 A0A8V8TMX9 A0A8V8TNC3 A0A8V8TPM7 B7ZAZ3 M0QYA9 O14526
PDB IDs		3Q5U	7OHI
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratinization Keratin Filament Protein Tag Activity Endocytic Vesicle Membrane Epidermis Development Protein Binding Female Meiosis I	Intermediate Filament Clathrin-coated Pit Protein Targeting To Vacuole Involved In Autophagy Endosome To Plasma Membrane Transport Vesicle Regulation Of SMAD Protein Signal Transduction Low-density Lipoprotein Particle Receptor Binding Cytosol Positive Regulation Of Aggrephagy Negative Regulation Of Protein Localization To Plasma Membrane Regulation Of Enamel Mineralization Clathrin Coat Of Coated Pit Keratin Filament Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Vesicle-mediated Transport Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Protein Binding Regulation Of Growth Receptor Metabolic Process SMAD Binding Negative Regulation Of Protein Localization Protein Targeting To Vacuole Negative Regulation Of Growth
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