EFEMP2 and PIDD1

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EFEMP2	PIDD1
Description		EGF-like fibulin extracellular matrix protein 2	p53-induced death domain protein 1
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GO Annotations	Cellular Component	Microfibril Extracellular Region Basement Membrane Extracellular Matrix Extracellular Exosome Elastic Fiber Extracellular Vesicle	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Endopeptidase Complex
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Heparin Binding Protein Homodimerization Activity	Endopeptidase Activity Death Receptor Binding Protein Binding Hydrolase Activity
	Biological Process	Aorta Development Elastic Fiber Assembly Aorta Smooth Muscle Tissue Morphogenesis Artery Development Vascular Associated Smooth Muscle Cell Development Regulation Of Collagen Fibril Organization Positive Regulation Of Collagen Fibril Organization Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Positive Regulation Of Smooth Muscle Cell-matrix Adhesion	Apoptotic Process DNA Damage Response Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Autoprocessing DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres	TP53 Regulates Transcription of Caspase Activators and Caspases
Drugs
Diseases		Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS		Acne (severe) ( 24927181) Adult body size ( 32376654) Birth weight ( 31043758) Body size at age 10 ( 32376654) Monocyte count ( 32888494) Retinal detachment or retinal break ( 31816047)	Breast cancer ( 29059683)
Interacting Genes		133 interacting genes: ADAMTSL4 AMMECR1 ANAPC11 AP1M1 APEX2 AQP1 ARRDC3 ATN1 ATXN1 ATXN7 BAG6 C3 C5orf24 CACNA1A CATSPER1 CCDC33 CCND3 CCNK CDPF1 CLPP CNNM3 COL8A1 CREB5 CXCL5 CYSRT1 DGCR6 DOK7 DYRK1A FAM107A FAM110A FAM124B FAM74A4 FAM90A1 FBXW5 FTO FXR1 GFI1B GLRX3 HDAC4 HHEX HHIPL1 HOXA1 HPCAL1 HSD3B7 HSPA12B HSPBP1 IGFBP6 IL16 INCA1 ITGB5 KLF1 KRTAP10-8 KRTAP11-1 KRTAP12-2 KRTAP13-3 KRTAP19-5 KRTAP26-1 KRTAP3-2 LBX1 LCE1A LCE1C LCE1E LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LINGO1 LNX1 MDFI MEOX2 MRPL12 MXI1 NEDD4L NOS3 NR1D2 NTM NUFIP2 OTX1 P2RX7 PIDD1 PITX1 PLSCR1 PLSCR4 PROP1 PRPF31 PRR32 PTGER3 RAB40B RBAK RBP3 RBPMS RERE RHOXF2 RHPN1 RIBC2 RNF138 SGTA SGTB SHANK3 SLC16A5 SLC23A1 SLC25A48 SPACA9 SPATA24 SPATA3 SPATA8 SPRY4 STK16 TCAF1 THAP7 TLE5 TLX3 TP53 TRIB3 TRIM42 UBQLN1 UBQLN4 USP21 ZNF263 ZNF345 ZNF426 ZNF558 ZNF57 ZNF581 ZNF587 ZNF638 ZNF670 ZNF699 ZNF768 ZNF774 ZNF837	17 interacting genes: AFP ATM CASP2 CCDC85B CRADD EFEMP2 FADD HSD17B14 KHDC4 MADD MAFG MDFI MTNR1B POGZ PRKDC SOX8 TEAD3
Entrez ID		30008	55367
HPRD ID		05221	11284
Ensembl ID		ENSG00000172638	ENSG00000177595
Uniprot IDs		O95967 Q9H3D5	Q9HB75
PDB IDs		2KL7	2OF5
Enriched GO Terms of Interacting Partners?		Protein Binding Keratinization DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Epidermis Development Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Identical Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Regulation Of RNA Metabolic Process CD4 Receptor Binding Regulation Of Primary Metabolic Process Tissue Development Regulation Of Nucleobase-containing Compound Metabolic Process TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Nucleus Sequence-specific Double-stranded DNA Binding Intermediate Filament Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of ERAD Pathway Zinc Ion Binding	DNA-dependent Protein Kinase Activity Histone H2AXS139 Kinase Activity Endopeptidase Complex Cell Death Programmed Cell Death Signal Transduction In Response To DNA Damage DNA Damage Response, Signal Transduction By P53 Class Mediator Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Mechanical Stimulus Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death V(D)J Recombination Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription By RNA Polymerase II Ectopic Germ Cell Programmed Cell Death Death Receptor Binding Reproductive Process Extrinsic Apoptotic Signaling Pathway Programmed Cell Death Involved In Cell Development Execution Phase Of Apoptosis Double-strand Break Repair Via Homologous Recombination Recombinational Repair Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of RNA Biosynthetic Process Intrinsic Apoptotic Signaling Pathway Positive Regulation Of DNA-templated Transcription Cell Fate Commitment Cellular Developmental Process Ovulation Cycle Process Somitogenesis Peptidyl-serine Phosphorylation DNA Damage Response Somatic Cell DNA Recombination Response To Mechanical Stimulus T Cell Differentiation In Thymus Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Smooth Muscle Cell-matrix Adhesion D-threo-aldose 1-dehydrogenase Activity Thymus Development Positive Regulation Of RNA Metabolic Process Double-strand Break Repair Developmental Process Involved In Reproduction Regulation Of DNA-templated Transcription
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