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EFEMP2 and DYRK1A
Number of citations of the paper that reports this interaction (PubMedID
35914814
)
83
Data Source:
BioGRID
(two hybrid)
EFEMP2
DYRK1A
Description
EGF-like fibulin extracellular matrix protein 2
dual specificity tyrosine phosphorylation regulated kinase 1A
Image
GO Annotations
Cellular Component
Microfibril
Extracellular Region
Basement Membrane
Extracellular Matrix
Extracellular Exosome
Elastic Fiber
Extracellular Vesicle
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Microtubule
Neurofilament
Actin Filament
Nuclear Speck
Axon
Dendrite
Ribonucleoprotein Complex
Molecular Function
Extracellular Matrix Structural Constituent
Calcium Ion Binding
Protein Binding
Heparin Binding
Protein Homodimerization Activity
Nucleotide Binding
Transcription Coactivator Activity
Actin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Cytoskeletal Protein Binding
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Tubulin Binding
Kinase Activity
Transferase Activity
Identical Protein Binding
Tau Protein Binding
Tau-protein Kinase Activity
Protein Serine Kinase Activity
Histone H3T45 Kinase Activity
Splicing Factor Binding
Biological Process
Aorta Development
Elastic Fiber Assembly
Aorta Smooth Muscle Tissue Morphogenesis
Artery Development
Vascular Associated Smooth Muscle Cell Development
Regulation Of Collagen Fibril Organization
Positive Regulation Of Collagen Fibril Organization
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Aortic Smooth Muscle Cell Differentiation
Positive Regulation Of Smooth Muscle Cell-matrix Adhesion
Regulation Of Alternative MRNA Splicing, Via Spliceosome
Double-strand Break Repair Via Homologous Recombination
Double-strand Break Repair Via Nonhomologous End Joining
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Nervous System Development
Circadian Rhythm
Peptidyl-tyrosine Phosphorylation
Negative Regulation Of Microtubule Polymerization
Negative Regulation Of Heterochromatin Formation
Positive Regulation Of RNA Splicing
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of DNA-templated Transcription
Protein Autophosphorylation
Negative Regulation Of MRNA Splicing, Via Spliceosome
Regulation Of Amyloid-beta Formation
Regulation Of Neurofibrillary Tangle Assembly
Pathways
Molecules associated with elastic fibres
Molecules associated with elastic fibres
G0 and Early G1
Drugs
N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide
Fostamatinib
Diseases
Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS
Acne (severe) (
24927181
)
Adult body size (
32376654
)
Birth weight (
31043758
)
Body size at age 10 (
32376654
)
Monocyte count (
32888494
)
Retinal detachment or retinal break (
31816047
)
Basophil count (
32888494
)
Basophil percentage of white cells (
32888494
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
HIV-1 replication (
21364930
)
Mean corpuscular hemoglobin (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Metabolic syndrome (
20694148
)
Neutrophil count (
32888494
)
Parkinson's disease (
32201043
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Stroke (
30383316
)
Systolic blood pressure (
32902719
)
White blood cell count (
32888494
)
Interacting Genes
133 interacting genes:
ADAMTSL4
AMMECR1
ANAPC11
AP1M1
APEX2
AQP1
ARRDC3
ATN1
ATXN1
ATXN7
BAG6
C3
C5orf24
CACNA1A
CATSPER1
CCDC33
CCND3
CCNK
CDPF1
CLPP
CNNM3
COL8A1
CREB5
CXCL5
CYSRT1
DGCR6
DOK7
DYRK1A
FAM107A
FAM110A
FAM124B
FAM74A4
FAM90A1
FBXW5
FTO
FXR1
GFI1B
GLRX3
HDAC4
HHEX
HHIPL1
HOXA1
HPCAL1
HSD3B7
HSPA12B
HSPBP1
IGFBP6
IL16
INCA1
ITGB5
KLF1
KRTAP10-8
KRTAP11-1
KRTAP12-2
KRTAP13-3
KRTAP19-5
KRTAP26-1
KRTAP3-2
LBX1
LCE1A
LCE1C
LCE1E
LCE2C
LCE2D
LCE3A
LCE3C
LCE3D
LCE3E
LINGO1
LNX1
MDFI
MEOX2
MRPL12
MXI1
NEDD4L
NOS3
NR1D2
NTM
NUFIP2
OTX1
P2RX7
PIDD1
PITX1
PLSCR1
PLSCR4
PROP1
PRPF31
PRR32
PTGER3
RAB40B
RBAK
RBP3
RBPMS
RERE
RHOXF2
RHPN1
RIBC2
RNF138
SGTA
SGTB
SHANK3
SLC16A5
SLC23A1
SLC25A48
SPACA9
SPATA24
SPATA3
SPATA8
SPRY4
STK16
TCAF1
THAP7
TLE5
TLX3
TP53
TRIB3
TRIM42
UBQLN1
UBQLN4
USP21
ZNF263
ZNF345
ZNF426
ZNF558
ZNF57
ZNF581
ZNF587
ZNF638
ZNF670
ZNF699
ZNF768
ZNF774
ZNF837
145 interacting genes:
-
ABCA2
ABHD12
ADAM19
ADAM22
ADAM23
ADAM9
ADAMTS1
ADAMTS9
AGAP1
AMPH
APP
ASTN2
ATRN
ATRNL1
CACHD1
CCN1
CCNL2
CEP70
CFH
CKAP5
CLASRP
CLU
CREB1
CRIM1
CTNNA1
CYLD
DCAF5
DCHS2
DCTD
DKK3
DNM1
DNM3
DROSHA
DSCAM
DSCAML1
DVL3
DYNLL1
EFEMP1
EFEMP2
EIF2B5
ENPP2
ERBB3
ERC1
FAM53C
FBN1
FEZ1
FOXO1
GEMIN8
GLI1
GPR37L1
H2BC3
H3C1
H4C1
HMG20A
ID2
ITGB8
JCAD
KIF1A
KPNA4
KPNA6
KPRP
LAMB1
LATS2
LEO1
LIN52
LMO3
LRP1B
LRP2
LRP4
LTBP3
MAGEH1
MAPT
MEGF9
MIGA1
MTA1
MTA3
MYCBP2
MYT1L
NAP1L1
NCAPH2
NECAB3
NELL1
NELL2
NPC1
NUCB1
OSBPL1A
PCSK6
PEA15
PHYHIP
PJA1
PLAUR
PLP1
PNISR
PRDM4
PRKN
PSAP
PTOV1
RAPGEF2
RB1
RBL1
RECK
RNF169
RNF216
RNF220
RSBN1L
SCRIB
SF3B1
SMAD2
SNCA
SNRNP70
SPRED1
SPRED2
SPRY2
SPTBN1
SRPK2
SRSF1
SRSF10
SRSF4
SRSF5
STAB1
STX1A
SULF1
THBS1
TMEFF1
TMEM59
TNFRSF25
TRAF2
TRIM66
TROAP
TSPYL2
USP13
USP32
USP34
USP54
USP7
VLDLR
VPS54
WIF1
XRCC6
YWHAB
YWHAE
YWHAG
ZBTB11
ZNF365
Entrez ID
30008
1859
HPRD ID
05221
09018
Ensembl ID
ENSG00000172638
ENSG00000157540
Uniprot IDs
O95967
Q9H3D5
A0A2R8Y6I6
Q13627
PDB IDs
2KL7
2VX3
2WO6
3ANQ
3ANR
4AZE
4MQ1
4MQ2
4NCT
4YLJ
4YLK
4YLL
4YU2
5A3X
5A4E
5A4L
5A4Q
5A4T
5A54
5AIK
6A1F
6A1G
6EIF
6EIJ
6EIL
6EIP
6EIQ
6EIR
6EIS
6EIV
6EJ4
6LN1
6QU2
6S11
6S14
6S17
6S1B
6S1H
6S1I
6S1J
6T6A
6UIP
6UWY
6YF8
7A4O
7A4R
7A4S
7A4W
7A4Z
7A51
7A52
7A53
7A55
7A5B
7A5D
7A5L
7A5N
7AJ2
7AJ4
7AJ5
7AJ7
7AJ8
7AJA
7AJM
7AJS
7AJV
7AJW
7AJY
7AK2
7AKA
7AKB
7AKE
7AKL
7FHS
7FHT
7O7K
7OY6
7Z5N
7ZH8
8C3G
8C3Q
8C3R
8R8E
8T2H
8YEV
Enriched GO Terms of Interacting Partners
?
Protein Binding
Keratinization
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Epidermis Development
Regulation Of Transcription By RNA Polymerase II
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Identical Protein Binding
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
DNA Binding
Regulation Of RNA Metabolic Process
CD4 Receptor Binding
Regulation Of Primary Metabolic Process
Tissue Development
Regulation Of Nucleobase-containing Compound Metabolic Process
TRC Complex
Post-translational Protein Targeting To Endoplasmic Reticulum Membrane
Nucleus
Sequence-specific Double-stranded DNA Binding
Intermediate Filament
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of ERAD Pathway
Zinc Ion Binding
Regulation Of Developmental Process
Regulation Of Cell Differentiation
Regulation Of Multicellular Organismal Process
Positive Regulation Of Signaling
Regulation Of Multicellular Organismal Development
Calcium Ion Binding
Positive Regulation Of Developmental Process
Positive Regulation Of Cell Communication
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Signal Transduction
Negative Regulation Of Developmental Process
Regulation Of Metabolic Process
Regulation Of Phosphorylation
Negative Regulation Of Signal Transduction
Regulation Of Signal Transduction
Heparin Binding
Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Anatomical Structure Morphogenesis
Regulation Of Macromolecule Metabolic Process
Regulation Of Signaling
Developmental Process
Negative Regulation Of Lens Fiber Cell Differentiation
Regulation Of Primary Metabolic Process
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Regulation Of Protein Metabolic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of Metabolic Process
Regulation Of Cell Communication
Regulation Of Wnt Signaling Pathway
Positive Regulation Of Cell Differentiation
Integrin Binding
Positive Regulation Of Programmed Cell Death
Low-density Lipoprotein Particle Receptor Activity
Positive Regulation Of Macromolecule Metabolic Process
Cell Surface Receptor Signaling Pathway
Macromolecule Metabolic Process
Regulation Of Protein Localization
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Canonical Wnt Signaling Pathway
Extracellular Region
Apolipoprotein Binding
Negative Regulation Of Wnt Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of Protein Catabolic Process
Positive Regulation Of Phosphate Metabolic Process
Response To Growth Factor
Neuron Projection Morphogenesis
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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