PSMC6 and CCDC85B

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PSMC6	CCDC85B
Description		proteasome 26S subunit, ATPase 6	coiled-coil domain containing 85B
Image			No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Regulatory Particle, Base Subcomplex Membrane Inclusion Body Proteasome Accessory Complex Cytosolic Proteasome Complex Extracellular Exosome	Nucleus Cytoplasm Centrosome Cytoskeleton Adherens Junction Anchoring Junction
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Protein-macromolecule Adaptor Activity Proteasome-activating Activity Identical Protein Binding	Protein Binding Delta-catenin Binding
	Biological Process	ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Inclusion Body Assembly Positive Regulation Of Proteasomal Protein Catabolic Process	Cell Differentiation Negative Regulation Of Cell Growth Negative Regulation Of Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling SARS-CoV-1 targets host intracellular signalling and regulatory pathways KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Acne (severe) ( 24927181) Asthma ( 31959851) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		19 interacting genes: BYSL C1orf216 CCDC146 CCDC85B CCT2 CDC37 CDC42 CEBPA CRK CRKL CYB5R2 GTF2A1 PAAF1 PSMA6 PSMD9 SDCBP SEC14L5 SMARCE1 UBE2I	138 interacting genes: AGGF1 AKAP17A AKIRIN2 APEX2 AQP1 ATOSB BEX2 BEX3 BIRC5 C19orf25 C21orf91 C8orf48 CARD9 CATSPERT CCDC112 CCDC116 CCDC120 CCDC185 CCDC33 CCNK CDK18 CDKN1A CENPP CEP70 CFAP53 CHCHD3 CHLSN COPS4 CWC25 DEPP1 DEUP1 DOK5 DTNB DUSP13B EIF3H ENKD1 EPS8 EXOC7 EXOC8 EZH2 FAM107A FAM124B FAM13C FAM27E3 FAM50B FAM74A4 FASTKD5 FBF1 FCHSD2 FNDC11 FXR2 GCC1 GFI1B GPANK1 HMG20B HNRNPC IKZF5 INO80B KANSL1 KIAA0408 KRT17 KRT18 KRT20 KRT6A LDOC1 LMO3 LNX1 LZTS2 MBIP MCM10 MCRS1 MEAF6 MOAP1 MOB1A MOB4 NDUFA5 NEK6 NIF3L1 NRIP1 NUP54 ODAD4 PBXIP1 PIDD1 PKN1 PLEKHF2 PLOD3 POLR2L PRC1 PRPF3 PSMA1 PSMC1 PSMC6 PSMF1 RALYL RBM41 RBM7 RGS8 RIBC2 RNF8 SCNM1 SETD5 SF3A3 SIX1 SLU7 SMARCD1 SPATA46 SYT17 SYTL4 TASOR2 TCEANC TCHP TEAD4 THAP7 TNNI1 TNNT1 TSPYL4 TTC14 TUBGCP4 USP2 UTP14A UTP6 VPS72 ZBTB16 ZBTB5 ZC2HC1C ZFC3H1 ZFP36 ZNF165 ZNF205 ZNF250 ZNF337 ZNF417 ZNF426 ZNF564 ZNF587 ZNF638 ZNF764 ZNF821
Entrez ID		5706	11007
HPRD ID		04086	16101
Ensembl ID		ENSG00000100519	ENSG00000175602
Uniprot IDs		A0A087X2I1 P62333	Q15834
PDB IDs		5GJQ 5GJR 5L4G 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHJ 5VHM 5VHN 5VHO 5VHP 5VHQ 5VHR 5VHS 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8CVT 8JRI 8JRT 8JTI 8K0G 8USB 8USC 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q
Enriched GO Terms of Interacting Partners?		Helper T Cell Diapedesis Cerebellar Neuron Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Diapedesis Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Endothelin Receptor Signaling Pathway Regulation Of Cell Growth Positive Regulation Of Receptor Clustering Reelin-mediated Signaling Pathway Postsynaptic Specialization Assembly Establishment Of Cell Polarity Regulation Of Receptor Clustering Positive Regulation Of Rac Protein Signal Transduction Kinase Binding Mononuclear Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Locomotion Regulation Of Growth Positive Regulation Of Cell Motility Positive Regulation Of Cell-substrate Adhesion Nuclear Matrix Postsynaptic Specialization Organization Cellular Component Assembly Regulation Of Rac Protein Signal Transduction Positive Regulation Of Cell Growth Establishment Or Maintenance Of Cell Polarity T Cell Migration Macrophage Differentiation Positive Regulation Of Intracellular Signal Transduction Protein-containing Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Phosphotyrosine Residue Binding Dendrite Development Positive Regulation Of Protein Localization Central Nervous System Neuron Development Purine Ribonucleoside Triphosphate Binding Interleukin-5 Receptor Complex SUMO Conjugating Enzyme Activity Regulation Of Cell Adhesion Mediated By Integrin Regulation Of T Cell Migration Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Communication Leukocyte Migration Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Signaling GBD Domain Binding	Protein Binding Nucleus Nuclear Speck Zinc Ion Binding Spindle Pole Spindle Midzone Assembly Keratin Filament Chromatin Organization Regulation Of RNA Metabolic Process
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