PSMC6 and CCT2

Number of citations of the paper that reports this interaction (PMID 23190606)
1

Data Source:
BioGRID (pull down)

		PSMC6	CCT2
Gene Name		proteasome (prosome, macropain) 26S subunit, ATPase, 6	chaperonin containing TCP1, subunit 2 (beta)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytosol Membrane Proteasome Accessory Complex Extracellular Vesicular Exosome	Zona Pellucida Receptor Complex Cytoplasm Cytosol Chaperonin-containing T-complex Microtubule Cell Body Extracellular Vesicular Exosome
	Molecular Function	Protein Binding ATP Binding ATPase Activity Protein Binding, Bridging	Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Unfolded Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Amino Acid Metabolic Process Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Gene Expression Viral Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway	Protein Folding Binding Of Sperm To Zona Pellucida Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Chaperone-mediated Protein Complex Assembly Toxin Transport
Pathways		Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease T41 mutants of beta-catenin aren't phosphorylated Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex Stabilization of p53 S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling DNA Replication Pre-Initiation S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Autodegradation of the E3 ubiquitin ligase COP1 AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Adaptive Immune System CDK-mediated phosphorylation and removal of Cdc6 Hedgehog ligand biogenesis APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids HIV Infection Ubiquitin-dependent degradation of Cyclin D APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Autodegradation of Cdh1 by Cdh1:APC/C p53-Dependent G1 DNA Damage Response S37 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN p53-Independent DNA Damage Response p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Vpu mediated degradation of CD4 Synthesis of DNA M/G1 Transition Ubiquitin-dependent degradation of Cyclin D1 TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Signaling by Hedgehog Regulation of mitotic cell cycle Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Ubiquitin Mediated Degradation of Phosphorylated Cdc25A p53-Dependent G1/S DNA damage checkpoint truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt Cyclin E associated events during G1/S transition APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA CDK-mediated phosphorylation and removal of Cdc6 RNF mutants show enhanced WNT signaling and proliferation G1/S Transition truncations of AMER1 destabilize the destruction complex Processing-defective Hh variants abrogate ligand secretion Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Regulation of activated PAK-2p34 by proteasome mediated degradation AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic Metaphase and Anaphase Regulation of ornithine decarboxylase (ODC) Antigen processing: Ubiquitination & Proteasome degradation Orc1 removal from chromatin Mitotic Anaphase M Phase APC truncation mutants are not K63 polyubiquitinated Metabolism of amino acids and derivatives Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation Regulation of DNA replication Cell Cycle, Mitotic beta-catenin independent WNT signaling Orc1 removal from chromatin Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Cross-presentation of soluble exogenous antigens (endosomes) Antigen processing-Cross presentation CDT1 association with the CDC6:ORC:origin complex ER-Phagosome pathway	Cargo trafficking to the periciliary membrane Protein folding Organelle biogenesis and maintenance Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Association of TriC/CCT with target proteins during biosynthesis Chaperonin-mediated protein folding Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Height ( 18391951)
Protein-Protein Interactions		10 interactors: C1orf216 CCDC146 CCDC85B CCT2 CRK CYB5R2 PAAF1 PSMC3 PSMD9 SDCBP	18 interactors: ACTA1 ACTB EEF2 ERLIN2 FCHSD2 HSP90AB1 HSP90B1 PRPF40A PSMC6 PSMD2 RPS3 SSSCA1 SUMO4 TUBA1B TUBB VAV2 VRK2 YWHAG
Entrez ID		5706	10576
HPRD ID		04086	06895
Ensembl ID		ENSG00000100519	ENSG00000166226
Uniprot IDs		P62333	P78371
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Ligase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Ephrin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Ubiquitination Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Viral Process Signal Transduction By P53 Class Mediator Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Positive Regulation Of Transferase Activity Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Regulation Of Cell Cycle G1/S Phase Transition Proteasome Regulatory Particle Assembly Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Positive Regulation Of Wnt Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Positive Regulation Of Extracellular Vesicular Exosome Assembly Protein Polyubiquitination Negative Regulation Of Wnt Signaling Pathway Regulation Of Extracellular Vesicular Exosome Assembly	Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Division Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cellular Protein Metabolic Process Cell Cycle Phase Transition Positive Regulation Of Transferase Activity Regulation Of Apoptotic Process Protein Folding Immune System Process Regulation Of Cell Death Cell Cycle Process Endocytosis Organelle Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Innate Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Response To Stress Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process Immune Response-regulating Signaling Pathway Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process ER-associated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Interleukin-4 Modification-dependent Protein Catabolic Process Movement Of Cell Or Subcellular Component Cellular Response To Stress Apoptotic Process Regulation Of Protein Metabolic Process Positive Regulation Of Catalytic Activity Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Programmed Cell Death Response To Interleukin-4 Cellular Protein Catabolic Process Cell Death Death Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Catalytic Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of DNA N-glycosylase Activity Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint 'de Novo' Posttranslational Protein Folding Protein Catabolic Process Phagocytosis
Tagcloud ?		11p11 12q15 17q23 19p13 19q13 20s 26s 7q22 atpases charges consitute machine modules mss1 multisubunit p42 pa700 proteasome psmc1 psmc2 psmc3 psmc4 psmc5 q13 q22 q23 s4 tbp1 tbp7	antral atresia atretic bga build categorized cattle cyp11a1 cyp19a1 dab2 dairy dsg2 e2f1 follicle follicles follicular granulosa hybridized microarrays offers oocyte originating phases plateau segregation steroidogenesis tgm2 transcriptomic ultimately
Tagcloud (Difference) ?		11p11 12q15 17q23 19p13 19q13 20s 26s 7q22 atpases charges consitute machine modules mss1 multisubunit p42 pa700 proteasome psmc1 psmc2 psmc3 psmc4 psmc5 q13 q22 q23 s4 tbp1 tbp7	antral atresia atretic bga build categorized cattle cyp11a1 cyp19a1 dab2 dairy dsg2 e2f1 follicle follicles follicular granulosa hybridized microarrays offers oocyte originating phases plateau segregation steroidogenesis tgm2 transcriptomic ultimately
Tagcloud (Intersection) ?