PLSCR3 and LCE4A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLSCR3	LCE4A
Description		phospholipid scramblase 3	late cornified envelope 4A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Inner Membrane Cytosol Plasma Membrane Membrane Mitochondrial Membrane
	Molecular Function	Magnesium Ion Binding Calcium Ion Binding Protein Binding SH3 Domain Binding Phospholipid Scramblase Activity Lead Ion Binding Mercury Ion Binding Calcium-dependent Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Lipid Transport Apoptotic Process Mitochondrial Membrane Organization Plasma Membrane Phospholipid Scrambling Glucose Homeostasis Cholesterol Homeostasis Regulation Of Apoptotic Process Cellular Response To Lipopolysaccharide Regulation Of Release Of Cytochrome C From Mitochondria	Epidermis Development Keratinization
Pathways			Formation of the cornified envelope
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)
Interacting Genes		34 interacting genes: ACTMAP AIPL1 C10orf55 C22orf39 CATSPER1 COL8A1 HOXA1 INCA1 KRTAP11-1 KRTAP15-1 KRTAP19-6 KRTAP19-7 KRTAP3-2 KRTAP3-3 KRTAP6-1 LCE1C LCE2B LCE4A LCE5A MAPKBP1 NAA10 NXPE2 PITX1 PLSCR1 PRKCD RUNX1T1 S100A7L2 SMCP STK16 TNIP3 TNS2 TRIP13 WWOX ZIC1	79 interacting genes: ADAMTSL4 ALPP CRCT1 CREB5 CYSRT1 FUCA2 GRN HOXA1 HSD3B7 KRT31 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP17-1 KRTAP3-1 KRTAP3-2 KRTAP3-3 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE5A MDFI MEOX2 NBPF19 NOTCH2NLA NUFIP2 OTX1 P4HB PLSCR1 PLSCR3 RGS17 RGS19 RGS20 RNF111 SLC39A7 SMCP SPRY1 SPRY2 TGM1 TRIM42 TSPAN4 VASN VWC2 ZNF655
Entrez ID		57048	199834
HPRD ID		07400	17264
Ensembl ID		ENSG00000187838	ENSG00000187170
Uniprot IDs		Q9NRY6	Q5TA78
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratinization	Intermediate Filament Keratin Filament Epidermis Development Keratinization Tissue Development Hair Cycle Protein Binding Cytosol Lead Ion Binding Identical Protein Binding Mercury Ion Binding Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Bud Elongation Involved In Lung Branching Interstitial Matrix Regulation Of Lens Fiber Cell Differentiation
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