PLSCR3 and AIPL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLSCR3	AIPL1
Description		phospholipid scramblase 3	AIP like 1 HSP90 co-chaperone
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Inner Membrane Cytosol Plasma Membrane Membrane Mitochondrial Membrane	Photoreceptor Inner Segment Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Magnesium Ion Binding Calcium Ion Binding Protein Binding SH3 Domain Binding Phospholipid Scramblase Activity Lead Ion Binding Mercury Ion Binding Calcium-dependent Protein Binding	Farnesylated Protein Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Unfolded Protein Binding
	Biological Process	Lipid Transport Apoptotic Process Mitochondrial Membrane Organization Plasma Membrane Phospholipid Scrambling Glucose Homeostasis Cholesterol Homeostasis Regulation Of Apoptotic Process Cellular Response To Lipopolysaccharide Regulation Of Release Of Cytochrome C From Mitochondria	Retina Homeostasis Apoptotic Process Visual Perception Phototransduction, Visible Light Protein Farnesylation Regulation Of Opsin-mediated Signaling Pathway Negative Regulation Of Apoptotic Process
Pathways
Drugs
Diseases			Leber congenital amaurosis (LCR)
GWAS			C-reactive protein levels ( 29403010 33339817) Cognitive decline rate in late mild cognitive impairment ( 26252872) Hormone measurements ( 23696881) Manganese levels ( 26025379) Paclitaxel-induced cytotoxicity ( 26015512) Reading disability ( 32108986)
Interacting Genes		34 interacting genes: ACTMAP AIPL1 C10orf55 C22orf39 CATSPER1 COL8A1 HOXA1 INCA1 KRTAP11-1 KRTAP15-1 KRTAP19-6 KRTAP19-7 KRTAP3-2 KRTAP3-3 KRTAP6-1 LCE1C LCE2B LCE4A LCE5A MAPKBP1 NAA10 NXPE2 PITX1 PLSCR1 PRKCD RUNX1T1 S100A7L2 SMCP STK16 TNIP3 TNS2 TRIP13 WWOX ZIC1	10 interacting genes: ACD HSP90AA1 HSPA8 LBX1 NUB1 PLSCR3 POT1 SMAP1 TINF2 TXNL4B
Entrez ID		57048	23746
HPRD ID		07400	05092
Ensembl ID		ENSG00000187838	ENSG00000129221
Uniprot IDs		Q9NRY6	F1T0B5 F1T0B6 F1T0C0 F1T0C4 Q7Z3H1 Q9NZN9
PDB IDs			5U9A 5U9I 5U9J 5U9K 5V35 6PX0
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratinization	Telomere Assembly Shelterin Complex Regulation Of Telomere Maintenance Via Telomerase Nuclear Telomere Cap Complex Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Capping Positive Regulation Of Telomere Maintenance Regulation Of DNA Biosynthetic Process Telomere Maintenance Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Chromosome Organization RNA-templated DNA Biosynthetic Process Regulation Of Telomere Maintenance Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Telomere Organization Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Chaperone-mediated Autophagy Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Regulation Of Chromosome Organization Negative Regulation Of Chromosome Organization Positive Regulation Of DNA Metabolic Process DNA Biosynthetic Process Protein Localization To Chromosome, Telomeric Region Establishment Of Protein Localization To Organelle Chromosome Organization Negative Regulation Of DNA Metabolic Process DNA Polymerase Binding Positive Regulation Of Telomere Maintenance Via Telomerase MHC Class II Protein Complex Binding Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Cellular Component Organization Protein Refolding Regulation Of DNA Metabolic Process Chromosome, Telomeric Region Positive Regulation Of Organelle Organization Protein Folding Chaperone Complex ATP-dependent Protein Folding Chaperone Regulation Of Organelle Organization Positive Regulation Of DNA Biosynthetic Process Protein Localization To Organelle Nucleic Acid Metabolic Process Negative Regulation Of Cellular Component Organization Chaperone-mediated Autophagy Translocation Complex Disassembly Protein Folding Chaperone DNA Metabolic Process
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