PLSCR3 and CATSPER1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PLSCR3	CATSPER1
Gene Name		phospholipid scramblase 3	cation channel, sperm associated 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Mitochondrial Membrane	Plasma Membrane Motile Cilium CatSper Complex
	Molecular Function	Calcium Ion Binding Protein Binding SH3 Domain Binding Phospholipid Scramblase Activity Calcium-dependent Protein Binding	Calcium Activated Cation Channel Activity Voltage-gated Calcium Channel Activity Protein Binding
	Biological Process	Apoptotic Process Phospholipid Scrambling Glucose Homeostasis Cholesterol Homeostasis Cellular Response To Lipopolysaccharide	Multicellular Organismal Development Spermatogenesis Single Fertilization Fusion Of Sperm To Egg Plasma Membrane Cell Differentiation Sperm Motility Multicellular Organism Reproduction Regulation Of Ion Transmembrane Transport Sperm-egg Recognition Regulation Of Calcium Ion Transport Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Calcium Ion Import Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential
Pathways			Sperm Motility And Taxes Fertilization
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CATSPER1 PLSCR1 PRKCD STK16 TRIP13	33 interactors: ADAMTSL4 AGR2 APOA2 BEGAIN CHIC2 CHRD EFEMP2 EMD KHDRBS2 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 MDFI MTUS2 NOTCH2NL PLSCR1 PLSCR3 RFX6 RGS20 RIMBP3 SCRG1 SPRY2 TRAF2 TRIP6
Entrez ID		57048	117144
HPRD ID		07400	09396
Ensembl ID		ENSG00000187838	ENSG00000175294
Uniprot IDs		Q9NRY6	Q8NEC5
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Positive Regulation Of Phospholipid Catabolic Process Transcription From RNA Polymerase II Promoter Interleukin-10 Production Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Platelet Activation Negative Regulation Of Filopodium Assembly Interleukin-12 Production Positive Regulation Of Ceramide Biosynthetic Process Phosphatidylserine Biosynthetic Process Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Peptidyl-tyrosine Phosphorylation Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Phospholipid Transport Negative Regulation Of Platelet Aggregation Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Glial Cell Apoptotic Process Gene Expression Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Phospholipid Scrambling Positive Regulation Of Cellular Biosynthetic Process Regulation Of Superoxide Anion Generation Female Meiosis I Regulation Of Microtubule-based Movement Blood Coagulation Hemostasis Regulation Of Platelet Aggregation Negative Regulation Of Platelet Activation Fusion Of Sperm To Egg Plasma Membrane Regulation Of Cell Activation Plasma Membrane Fusion Response To Interferon-beta Positive Regulation Of Protein Dephosphorylation Spermatogenesis Male Gamete Generation Neutrophil Activation Synaptonemal Complex Assembly Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Synaptonemal Complex Organization Oocyte Maturation Positive Regulation Of Lipid Catabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Phosphatidylserine Metabolic Process Wound Healing Response To Growth Factor Regulation Of Platelet Activation Cellular Senescence	Regulation Of Protein Transport Regulation Of Establishment Of Protein Localization Phospholipid Scrambling Regulation Of Protein Localization Phospholipid Transport Regulation Of Cellular Localization Regulation Of Protein Import Into Nucleus Negative Regulation Of Protein Transport Regulation Of Signaling Regulation Of Protein Localization To Nucleus Glandular Epithelial Cell Differentiation Regulation Of Nucleocytoplasmic Transport BMP Signaling Pathway Involved In Spinal Cord Dorsal/ventral Patterning Pancreatic Epsilon Cell Differentiation Negative Regulation Of Cholesterol Transporter Activity Pancreatic D Cell Differentiation I-kappaB Kinase/NF-kappaB Signaling Regulation Of Intracellular Protein Transport Positive Regulation Of Catalytic Activity Regulation Of Signal Transduction Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of JUN Kinase Activity Regulation Of Membrane Lipid Distribution Negative Regulation Of Protein Import Into Nucleus Mucus Secretion Regulation Of Cholesterol Transporter Activity Negative Regulation Of Cholesterol Import Acute Inflammatory Response Regulation Of MAP Kinase Activity Regulation Of Cytokine Production Involved In Immune Response Epithelium Development Cholesterol Homeostasis Lipid Transport Sterol Homeostasis Regulation Of JUN Kinase Activity Negative Regulation Of Protein Localization To Nucleus Lipid Localization Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Lung Goblet Cell Differentiation Regulation Of Cholesterol Import Negative Regulation Of Intracellular Protein Transport Tissue Development Regulation Of Transcription Factor Import Into Nucleus Developmental Process Positive Regulation Of Nucleocytoplasmic Transport Lobar Bronchus Development Release Of Cytoplasmic Sequestered NF-kappaB Diacylglycerol Catabolic Process Lipid Homeostasis
Tagcloud ?		abss alg associating bromopalmitate centrifugation ceramide disassembling dispensable e235q enlarged escrt exosomal exosomes fused gfp gw4869 hek names palmitoylated palmitoylation phospholipid q79l rab5a scramblases scrambling transferable vps4b	5k3 alpl armitage beadchip bovinesnp50 bull capn1 cohran dehygrogenase ethanolamine etnk1 friesian goldenhelix hibadh hydroxyisobutyrate kelch klhl1 loc785875 mc4r pdzrn4 prkcb rs110596818 rs110827324 rs110876480 rs29011704 sire srd5a2 svs7 trim36
Tagcloud (Difference) ?		abss alg associating bromopalmitate centrifugation ceramide disassembling dispensable e235q enlarged escrt exosomal exosomes fused gfp gw4869 hek names palmitoylated palmitoylation phospholipid q79l rab5a scramblases scrambling transferable vps4b	5k3 alpl armitage beadchip bovinesnp50 bull capn1 cohran dehygrogenase ethanolamine etnk1 friesian goldenhelix hibadh hydroxyisobutyrate kelch klhl1 loc785875 mc4r pdzrn4 prkcb rs110596818 rs110827324 rs110876480 rs29011704 sire srd5a2 svs7 trim36
Tagcloud (Intersection) ?