HPRT1

Gene Name		hypoxanthine phosphoribosyltransferase 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Hypoxanthine Phosphoribosyltransferase Activity Protein Binding Protein Homodimerization Activity Guanine Phosphoribosyltransferase Activity
	Biological Process	Response To Amphetamine Purine Nucleobase Metabolic Process Purine Nucleotide Biosynthetic Process Purine Ribonucleoside Salvage Adenine Salvage Guanine Salvage Grooming Behavior Locomotory Behavior Cytolysis Striatum Development Cerebral Cortex Neuron Differentiation Central Nervous System Neuron Development GMP Salvage IMP Salvage Dopamine Metabolic Process Purine-containing Compound Salvage Hypoxanthine Salvage Small Molecule Metabolic Process Positive Regulation Of Dopamine Metabolic Process GMP Catabolic Process IMP Metabolic Process Hypoxanthine Metabolic Process Lymphocyte Proliferation Dendrite Morphogenesis Protein Homotetramerization Nucleobase-containing Small Molecule Metabolic Process
Pathways		Purine metabolism Metabolism of nucleotides Purine salvage
Drugs		Azathioprine Mercaptopurine Alpha-Phosphoribosylpyrophosphoric Acid Pyrophosphate 2- 5--Monophosphate-9-Beta-D-Ribofuranosyl Xanthine 3h-Pyrazolo[4,3-D]Pyrimidin-7-Ol 9-Deazaguanine
Diseases
GWAS
Protein-protein Interactions		5 interactors: FANCA ISCU PRTFDC1 SDCBP WDYHV1
Entrez ID		3251
HPRD ID		02388
Ensembl ID		ENSG00000165704
Uniprot IDs		P00492
PDB IDs		1BZY 1D6N 1HMP 1Z7G 2VFA 3GEP 3GGC 3GGJ 4IJQ 4KN6
Enriched GO Terms of Interacting Partners?		Nitrogen Fixation Positive Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Substrate-dependent Cell Migration, Cell Extension Cellular Component Assembly
Tagcloud ?		cloning eif2 eif3 exerts gels gtp hershey homologue migrates migrating multisubunit p110 p116 p170 p35 p40 p44 p47 p48 p66 polyacrylamide raised recognizes ribosome sds stabilizes ternary trna