HPRT1 and FANCA

Number of citations of the paper that reports this interaction (PMID 14499622)
5

Data Source:
BioGRID (two hybrid)

		HPRT1	FANCA
Gene Name		hypoxanthine phosphoribosyltransferase 1	Fanconi anemia, complementation group A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Fanconi Anaemia Nuclear Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Hypoxanthine Phosphoribosyltransferase Activity Protein Binding Protein Homodimerization Activity Guanine Phosphoribosyltransferase Activity	Protein Binding
	Biological Process	Response To Amphetamine Purine Nucleobase Metabolic Process Purine Nucleotide Biosynthetic Process Purine Ribonucleoside Salvage Adenine Salvage Guanine Salvage Grooming Behavior Locomotory Behavior Cytolysis Striatum Development Cerebral Cortex Neuron Differentiation Central Nervous System Neuron Development GMP Salvage IMP Salvage Dopamine Metabolic Process Purine-containing Compound Salvage Hypoxanthine Salvage Small Molecule Metabolic Process Positive Regulation Of Dopamine Metabolic Process GMP Catabolic Process IMP Metabolic Process Hypoxanthine Metabolic Process Lymphocyte Proliferation Dendrite Morphogenesis Protein Homotetramerization Nucleobase-containing Small Molecule Metabolic Process	DNA Repair Protein Complex Assembly Male Meiosis Male Gonad Development Female Gonad Development Regulation Of Cell Proliferation
Pathways		Purine metabolism Metabolism of nucleotides Purine salvage	Fanconi Anemia pathway
Drugs		Azathioprine Mercaptopurine Alpha-Phosphoribosylpyrophosphoric Acid Pyrophosphate 2- 5--Monophosphate-9-Beta-D-Ribofuranosyl Xanthine 3h-Pyrazolo[4,3-D]Pyrimidin-7-Ol 9-Deazaguanine
Diseases
GWAS
Protein-Protein Interactions		5 interactors: FANCA ISCU PRTFDC1 SDCBP WDYHV1	46 interactors: AKT1 ALDOA ATP5B ATR AZIN1 BRCA1 CAPN1 CCT3 CD79A CDK1 CENPE DAXX DDX39B DNAJB1 DUS4L ENO1 FANCC FANCE FANCF FANCG GNB2 HES1 HPRT1 HSP90AA1 IFIT3 IKBKB KRT1 LIPG MKNK1 MX1 NAMPT NUB1 PRPF31 PSMA5 RPL18 SGK1 SMARCA4 SMARCC1 SMARCD3 SNX5 SPTAN1 TAF10 TCERG1 TCP1 TPT1 ZNF24
Entrez ID		3251	2175
HPRD ID		02388	06186
Ensembl ID		ENSG00000165704	ENSG00000187741
Uniprot IDs		P00492	H3BSR5 O15360 Q86U55
PDB IDs		1BZY 1D6N 1HMP 1Z7G 2VFA 3GEP 3GGC 3GGJ 4IJQ 4KN6
Enriched GO Terms of Interacting Partners?		Nitrogen Fixation Positive Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Substrate-dependent Cell Migration, Cell Extension Cellular Component Assembly	Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Response To Stress Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Protein Complex Assembly Cellular Response To Stress Peptidyl-serine Phosphorylation Metabolic Process Nucleosome Disassembly Response To Stimulus Immune System Process Positive Regulation Of Cellular Metabolic Process Cellular Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Metabolic Process Regulation Of Cellular Response To Heat Cellular Component Assembly Response To Heat Regulation Of Cellular Process Apoptotic Process Cell Cycle Checkpoint Regulation Of Protein Catabolic Process Programmed Cell Death Regulation Of Nitrogen Compound Metabolic Process Regulation Of Response To DNA Damage Stimulus DNA Repair Cell Cycle Process Innate Immune Response Response To Virus Cell Death Death Reproductive Process Positive Regulation Of Cellular Biosynthetic Process 'de Novo' Posttranslational Protein Folding Response To Organic Substance Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Nucleosome Organization 'de Novo' Protein Folding Positive Regulation Of Cell Cycle Positive Regulation Of Cellular Protein Catabolic Process Chromatin Assembly Or Disassembly DNA Damage Checkpoint Cellular Response To Heat Regulation Of Metabolic Process Regulation Of Cell Cycle Process Regulation Of Cell Cycle Regulation Of Apoptotic Process
Tagcloud ?		cloning eif2 eif3 exerts gels gtp hershey homologue migrates migrating multisubunit p110 p116 p170 p35 p40 p44 p47 p48 p66 polyacrylamide raised recognizes ribosome sds stabilizes ternary trna	aml anemia aplastic autosomal brca2 collaborate complicated cumulative cure decision fancd1 fanconi fancq genotypes gynecologic head inherited neck preemptive prone recessive risks solid squamous subset transplant usually wilms
Tagcloud (Difference) ?		cloning eif2 eif3 exerts gels gtp hershey homologue migrates migrating multisubunit p110 p116 p170 p35 p40 p44 p47 p48 p66 polyacrylamide raised recognizes ribosome sds stabilizes ternary trna	aml anemia aplastic autosomal brca2 collaborate complicated cumulative cure decision fancd1 fanconi fancq genotypes gynecologic head inherited neck preemptive prone recessive risks solid squamous subset transplant usually wilms
Tagcloud (Intersection) ?