UBQLN4 and SERPINE1

Number of citations of the paper that reports this interaction (PubMedID 16713569)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UBQLN4	SERPINE1
Description		ubiquilin 4	serpin family E member 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoplasmic Vesicle Nuclear Proteasome Complex Cytosolic Proteasome Complex Protein-containing Complex Perinuclear Region Of Cytoplasm Site Of DNA Damage	Extracellular Region Extracellular Space Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Serine Protease Inhibitor Complex Peptidase Inhibitor Complex
	Molecular Function	Protein Binding Polyubiquitin Modification-dependent Protein Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Peptidase Inhibitor Activity
	Biological Process	DNA Repair Ubiquitin-dependent Protein Catabolic Process Autophagy DNA Damage Response Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Response To Stress Negative Regulation Of Autophagosome Maturation Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	Angiogenesis Response To Bacterium Negative Regulation Of Plasminogen Activation Negative Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Blood Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Cell Migration Positive Regulation Of Interleukin-8 Production Negative Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Leukotriene Production Involved In Inflammatory Response Fibrinolysis Positive Regulation Of Angiogenesis Negative Regulation Of Proteolysis Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Inflammatory Response Positive Regulation Of Coagulation Defense Response To Gram-negative Bacterium Negative Regulation Of Fibrinolysis Negative Regulation Of Vascular Wound Healing Negative Regulation Of Wound Healing Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Cellular Response To Lipopolysaccharide Positive Regulation Of Monocyte Chemotaxis Replicative Senescence Dentinogenesis Positive Regulation Of Odontoblast Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Integrin-mediated Signaling Pathway
Pathways			Platelet degranulation BMAL1:CLOCK,NPAS2 activates circadian expression SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription ECM proteoglycans Dissolution of Fibrin Clot Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
Drugs			Alteplase Urokinase Reteplase Anistreplase Tenecteplase Drotrecogin alfa Troglitazone Colforsin Fibrinolysin Copper Bucladesine
Diseases			Inherited thrombophilia
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 29273807) Crohn's disease ( 28067908) General risk tolerance (MTAG) ( 30643258) Inflammatory bowel disease ( 23128233 28067908)	Blood protein levels ( 30072576) Nonunion in individuals with fractures ( 30680360) Plasma plasminogen activator levels ( 24578379) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020)
Interacting Genes		163 interacting genes: ADAM33 ADPGK AGR2 ANKRD13D AREG ARL4C ATP5IF1 ATP5MK ATXN1 BAG6 BPIFA1 C1orf94 C1QTNF1 CACNA1G CCDC107 CCDC134 CCDC136 CCDC14 CCDC33 CCL21 CD274 CD99 CDSN CEND1 COL8A1 COPB1 CPSF6 CRIPT CSTF2 CSTF2T CSTPP1 CTSB CYB5R1 DAZAP2 DKK3 DMPK DNAJB11 DTX2 EAPP EDN1 EEF1A1 EFEMP2 ELF5 EPDR1 ERP27 ERP29 FA2H FGFBP1 FKBP2 FKBP7 FZD7 GABRD GDI1 GJA1 GJA5 GJC1 GKAP1 GPX7 HAVCR1 HGS HK2 HSPA13 HSPA5 IGFBP6 IGHM IGLC1 IMMT IMPDH2 ITPRIPL1 KLHL26 KLHL42 LAT2 MDK MDM2 MIEF2 MIF4GD MLLT6 MOAP1 MTNR1B MYDGF NAE1 NME3 NOMO1 NOMO3 NOTCH2NLA NPHP1 NPPA NXF1 OAT ORC5 PBXIP1 PCDH17 PCDH8 PDIA5 PDLIM7 PELI2 PICK1 PIN1 PIP4K2B PLAAT3 PMEPA1 PNMA1 PPIB PPIC PRL PRPF40A PTN PTPRN PTPRN2 QSOX1 RAD23A RAI2 RBM10 RIC8A RNF11 RNPS1 ROBO2 RPN1 RSRC2 RUNX1T1 RXRA SCAF1 SCG2 SCG5 SCMH1 SEMG1 SERPINE1 SERPINH1 SERPINI2 SMAD3 SMAD9 SMARCB1 SPAG8 SPINT1 SPP1 SRGN SRSF2 STAM2 STMN1 SUPT20H TFF1 TGFB1I1 TNFRSF14 TNRC6B TRAF2 TRIB2 TRIM32 UBC UBQLN1 UBQLN2 UBR7 UNC119 UROS VIP WAC WWP2 YWHAQ ZBTB22 ZDHHC3 ZFPM2 ZG16 ZG16B ZNF205	25 interacting genes: ACTN4 ELANE F2 HSD17B11 IGFBP5 KLK2 KRT18 LMNA LRP1 LRP1B LRP2 MMP3 ORM1 PITX1 PLAT PLAU PLG SGTA SGTB TLX3 TMEM237 UBQLN1 UBQLN2 UBQLN4 VTN
Entrez ID		56893	5054
HPRD ID		05670	01418
Ensembl ID		ENSG00000160803	ENSG00000106366
Uniprot IDs		B4DZF6 Q59F94 Q9NRR5	B7ZAB0 P05121
PDB IDs			1A7C 1B3K 1C5G 1DB2 1DVM 1DVN 1LJ5 1OC0 3CVM 3EOX 3PB1 3Q02 3Q03 3R4L 3UT3 4AQH 4G8O 4G8R 4IC0 5BRR 5ZLZ 6GWN 6GWP 6GWQ 6I8S 6ZRV 7AQF 7AQG 9PAI
Enriched GO Terms of Interacting Partners?		Protein Binding Endoplasmic Reticulum Lumen Extracellular Region Regulation Of Transport SA Node Cell To Atrial Cardiac Muscle Cell Communication Protein Folding Extracellular Space Peptidyl-prolyl Cis-trans Isomerase Activity Positive Regulation Of Metabolic Process Regulation Of Cell Communication Cardiac Muscle Tissue Development AV Node Cell To Bundle Of His Cell Communication Positive Regulation Of Proteolysis Protein Disulfide Isomerase Activity Gap Junction Assembly Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cell Communication Involved In Cardiac Conduction Regulation Of Protein Catabolic Process Regulation Of Signaling Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Gap Junction Channel Activity Involved In SA Node Cell-atrial Cardiac Muscle Cell Electrical Coupling SA Node Cell To Atrial Cardiac Muscle Cell Communication By Electrical Coupling Regulation Of Macroautophagy Endoplasmic Reticulum Chaperone Complex Positive Regulation Of Cell Communication Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Negative Regulation Of Fat Cell Differentiation Tissue Development Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Neutrophil Migration Negative Regulation Of Cell Population Proliferation Endoplasmic Reticulum Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Epithelial Cell Proliferation Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Regulation Of Response To Endoplasmic Reticulum Stress ESCRT-0 Complex Positive Regulation Of Protein Metabolic Process Regulation Of Biological Quality Regulation Of Membrane Potential Positive Regulation Of Catabolic Process Regulation Of Proteolysis Positive Regulation Of Macroautophagy Collagen Binding Establishment Of Protein Localization MRNA Cleavage And Polyadenylation Specificity Factor Complex Peptidase Inhibitor Complex	Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Serine-type Endopeptidase Activity Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Fibrinolysis Serine-type Peptidase Activity Positive Regulation Of Wound Healing Regulation Of Proteolysis Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Proteolysis Regulation Of Protein Metabolic Process Low-density Lipoprotein Particle Receptor Activity Regulation Of Wound Healing Negative Regulation Of Proteolysis TRC Complex Positive Regulation Of ERAD Pathway Peptidase Activity Extracellular Space Regulation Of Smooth Muscle Cell Migration Regulation Of Response To Wounding Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Regulation Of ERAD Pathway Regulation Of Cell Migration Endopeptidase Activity Regulation Of Cell Motility Trans-synaptic Signaling By BDNF Positive Regulation Of Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Locomotion Blood Coagulation Coagulation Neutrophil-mediated Killing Of Gram-negative Bacterium Hemostasis Positive Regulation Of Lysosomal Protein Catabolic Process Serine Protease Inhibitor Complex Biological Process Involved In Interaction With Symbiont Zymogen Activation Polyubiquitin Modification-dependent Protein Binding Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Response To Endoplasmic Reticulum Stress Extracellular Matrix Blood Microparticle Negative Regulation Of Multicellular Organismal Process
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