UBQLN4 and GPX7

Number of citations of the paper that reports this interaction (PubMedID 16713569)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UBQLN4	GPX7
Description		ubiquilin 4	glutathione peroxidase 7
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoplasmic Vesicle Nuclear Proteasome Complex Cytosolic Proteasome Complex Protein-containing Complex Perinuclear Region Of Cytoplasm Site Of DNA Damage	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen
	Molecular Function	Protein Binding Polyubiquitin Modification-dependent Protein Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding	Catalase Activity Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Oxidoreductase Activity
	Biological Process	DNA Repair Ubiquitin-dependent Protein Catabolic Process Autophagy DNA Damage Response Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Response To Stress Negative Regulation Of Autophagosome Maturation Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	Response To Oxidative Stress Cellular Response To Oxidative Stress Cellular Oxidant Detoxification
Pathways			Detoxification of Reactive Oxygen Species
Drugs			Glutathione Glutathione Glutathione disulfide Benzoyl peroxide
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 29273807) Crohn's disease ( 28067908) General risk tolerance (MTAG) ( 30643258) Inflammatory bowel disease ( 23128233 28067908)	Joint mobility (Beighton score) ( 27182965)
Interacting Genes		163 interacting genes: ADAM33 ADPGK AGR2 ANKRD13D AREG ARL4C ATP5IF1 ATP5MK ATXN1 BAG6 BPIFA1 C1orf94 C1QTNF1 CACNA1G CCDC107 CCDC134 CCDC136 CCDC14 CCDC33 CCL21 CD274 CD99 CDSN CEND1 COL8A1 COPB1 CPSF6 CRIPT CSTF2 CSTF2T CSTPP1 CTSB CYB5R1 DAZAP2 DKK3 DMPK DNAJB11 DTX2 EAPP EDN1 EEF1A1 EFEMP2 ELF5 EPDR1 ERP27 ERP29 FA2H FGFBP1 FKBP2 FKBP7 FZD7 GABRD GDI1 GJA1 GJA5 GJC1 GKAP1 GPX7 HAVCR1 HGS HK2 HSPA13 HSPA5 IGFBP6 IGHM IGLC1 IMMT IMPDH2 ITPRIPL1 KLHL26 KLHL42 LAT2 MDK MDM2 MIEF2 MIF4GD MLLT6 MOAP1 MTNR1B MYDGF NAE1 NME3 NOMO1 NOMO3 NOTCH2NLA NPHP1 NPPA NXF1 OAT ORC5 PBXIP1 PCDH17 PCDH8 PDIA5 PDLIM7 PELI2 PICK1 PIN1 PIP4K2B PLAAT3 PMEPA1 PNMA1 PPIB PPIC PRL PRPF40A PTN PTPRN PTPRN2 QSOX1 RAD23A RAI2 RBM10 RIC8A RNF11 RNPS1 ROBO2 RPN1 RSRC2 RUNX1T1 RXRA SCAF1 SCG2 SCG5 SCMH1 SEMG1 SERPINE1 SERPINH1 SERPINI2 SMAD3 SMAD9 SMARCB1 SPAG8 SPINT1 SPP1 SRGN SRSF2 STAM2 STMN1 SUPT20H TFF1 TGFB1I1 TNFRSF14 TNRC6B TRAF2 TRIB2 TRIM32 UBC UBQLN1 UBQLN2 UBR7 UNC119 UROS VIP WAC WWP2 YWHAQ ZBTB22 ZDHHC3 ZFPM2 ZG16 ZG16B ZNF205	13 interacting genes: ASPH CEP70 CPEB2 CPNE7 ERO1A GET3 NCALD NTAQ1 SGTA SGTB TCF25 UBQLN2 UBQLN4
Entrez ID		56893	2882
HPRD ID		05670	13606
Ensembl ID		ENSG00000160803	ENSG00000116157
Uniprot IDs		B4DZF6 Q59F94 Q9NRR5	Q96SL4
PDB IDs			2P31
Enriched GO Terms of Interacting Partners?		Protein Binding Endoplasmic Reticulum Lumen Extracellular Region Regulation Of Transport SA Node Cell To Atrial Cardiac Muscle Cell Communication Protein Folding Extracellular Space Peptidyl-prolyl Cis-trans Isomerase Activity Positive Regulation Of Metabolic Process Regulation Of Cell Communication Cardiac Muscle Tissue Development AV Node Cell To Bundle Of His Cell Communication Positive Regulation Of Proteolysis Protein Disulfide Isomerase Activity Gap Junction Assembly Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cell Communication Involved In Cardiac Conduction Regulation Of Protein Catabolic Process Regulation Of Signaling Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Gap Junction Channel Activity Involved In SA Node Cell-atrial Cardiac Muscle Cell Electrical Coupling SA Node Cell To Atrial Cardiac Muscle Cell Communication By Electrical Coupling Regulation Of Macroautophagy Endoplasmic Reticulum Chaperone Complex Positive Regulation Of Cell Communication Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Negative Regulation Of Fat Cell Differentiation Tissue Development Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Neutrophil Migration Negative Regulation Of Cell Population Proliferation Endoplasmic Reticulum Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Epithelial Cell Proliferation Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Regulation Of Response To Endoplasmic Reticulum Stress ESCRT-0 Complex Positive Regulation Of Protein Metabolic Process Regulation Of Biological Quality Regulation Of Membrane Potential Positive Regulation Of Catabolic Process Regulation Of Proteolysis Positive Regulation Of Macroautophagy Collagen Binding Establishment Of Protein Localization MRNA Cleavage And Polyadenylation Specificity Factor Complex Peptidase Inhibitor Complex	TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of ERAD Pathway Regulation Of Proteolysis Regulation Of ERAD Pathway Protein Insertion Into ER Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Establishment Of Protein Localization To Membrane Positive Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Response To Endoplasmic Reticulum Stress Protein-N-terminal Glutamine Amidohydrolase Activity Negative Regulation Of Cytoplasmic Translational Elongation Protein Insertion Into Membrane Peptidyl-aspartic Acid 3-dioxygenase Activity Cellular Response To Calcium Ion Protein Targeting To Membrane Negative Regulation Of G Protein-coupled Receptor Internalization Protein-N-terminal Asparagine Amidohydrolase Activity Nuclear Proteasome Complex Autophagosome GET Complex Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway RQC Complex Negative Regulation Of Autophagosome Maturation Regulation Of Protein Catabolic Process BAT3 Complex Binding Negative Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Proteasomal Protein Catabolic Process Activation Of Store-operated Calcium Channel Activity Cytosolic Proteasome Complex Negative Regulation Of Translational Elongation Positive Regulation Of Store-operated Calcium Channel Activity Regulation Of Sequestering Of Calcium Ion Response To Calcium Ion Regulation Of Protein-containing Complex Disassembly Cellular Response To Stress Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Protein K48-linked Ubiquitination Cellular Response To Hypoxia Thiol Oxidase Activity Negative Regulation Of ERAD Pathway Cellular Response To Decreased Oxygen Levels
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