ICAM5 and ITGAL

Number of citations of the paper that reports this interaction (PMID 8995416)
9

Data Source:
HPRD (in vitro)

		ICAM5	ITGAL
Gene Name		intercellular adhesion molecule 5, telencephalin	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Immunological Synapse Plasma Membrane Cell-cell Junction Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin AlphaL-beta2 Complex Extracellular Vesicular Exosome
	Molecular Function	Integrin Binding Protein Binding	Protein Binding ICAM-3 Receptor Activity Protein Complex Binding Metal Ion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding
	Biological Process	Phagocytosis Cell Adhesion Single Organismal Cell-cell Adhesion	T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Movement Of Cell Or Subcellular Component Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Blood Coagulation Extracellular Matrix Organization Positive Regulation Of T Cell Proliferation Receptor Clustering Regulation Of Immune Response Activated T Cell Proliferation Positive Regulation Of Calcium-mediated Signaling Leukocyte Migration
Pathways			Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Adaptive Immune System
Drugs			Efalizumab Antithymocyte globulin Lovastatin 1-Acetyl-4-(4-{4-[(2-Ethoxyphenyl)Thio]-3-Nitrophenyl}Pyridin-2-Yl)Piperazine LFA703 (S)-2-((S)-3-ISOBUTYL-2,5-DIOXO-4-QUINOLIN-3-YLMETHYL-[1,4]DIAZEPAN-1YL)-N-METHYL-3-NAPHTALEN-2-YL-PROPIONAMIDE 7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrile 3-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)aniline
Diseases
GWAS			Ulcerative colitis ( 23128233)
Protein-Protein Interactions		4 interactors: ITGAL ITGB2 PSEN1 PSEN2	7 interactors: F11R ICAM1 ICAM3 ICAM5 PTPRC RANBP9 SHARPIN
Entrez ID		7087	3683
HPRD ID		03509	01079
Ensembl ID		ENSG00000105376	ENSG00000005844
Uniprot IDs		Q8N6I2 Q9UMF0	B2RAL6 P20701
PDB IDs		3BN3	1CQP 1DGQ 1IJ4 1LFA 1MJN 1MQ8 1MQ9 1MQA 1RD4 1T0P 1XDD 1XDG 1XUO 1ZON 1ZOO 1ZOP 2ICA 2K8O 2O7N 3BN3 3BQM 3BQN 3E2M 3EOA 3EOB 3F74 3F78 3HI6 3M6F 3TCX
Enriched GO Terms of Interacting Partners?		T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion T Cell Activation Involved In Immune Response Lymphocyte Activation Leukocyte Activation Single Organismal Cell-cell Adhesion Amyloid Precursor Protein Catabolic Process Cell Activation Leukocyte Activation Involved In Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Beta-amyloid Metabolic Process Amyloid Precursor Protein Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Membrane Protein Ectodomain Proteolysis Notch Receptor Processing Activated T Cell Proliferation Regulation Of Epidermal Growth Factor-activated Receptor Activity Cell Adhesion Locomotion Endoplasmic Reticulum Calcium Ion Homeostasis Immune Response Dorsal/ventral Neural Tube Patterning Regulation Of Immune System Process Positive Regulation Of Coagulation Membrane Protein Proteolysis Brain Morphogenesis Extracellular Matrix Organization Extracellular Structure Organization Movement Of Cell Or Subcellular Component Regulation Of Cellular Amino Acid Metabolic Process Receptor Clustering Thymus Development Immune Response-regulating Signaling Pathway Neural Tube Patterning Regulation Of Protein Tyrosine Kinase Activity Regulation Of Cellular Ketone Metabolic Process T Cell Proliferation Protein Localization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Somitogenesis Immune System Process Positive Regulation Of Immune Response Embryonic Morphogenesis Cell Fate Specification	Cell Adhesion Single Organismal Cell-cell Adhesion Establishment Of Endothelial Barrier Endothelial Cell Development Extracellular Matrix Organization Extracellular Structure Organization Endothelial Cell Differentiation Response To Radiation Locomotion Response To Sulfur Dioxide Endothelium Development Regulation Of Cytokine-mediated Signaling Pathway Epithelial Cell Differentiation Regulation Of Leukocyte Mediated Cytotoxicity Movement Of Cell Or Subcellular Component T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Immunoglobulin Biosynthetic Process Positive Regulation Of Hematopoietic Stem Cell Migration Response To Ionizing Radiation Tissue Development Regulation Of CD40 Signaling Pathway Protein Linear Polyubiquitination Regulation Of Intracellular Signal Transduction Cell Development Cell Differentiation Positive Regulation Of Intracellular Signal Transduction Cell Migration T Cell Antigen Processing And Presentation Receptor-mediated Virion Attachment To Host Cell Membrane To Membrane Docking Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Immune Response Epithelial Cell Development Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cellular Extravasation Negative Regulation Of T Cell Mediated Cytotoxicity Cell Motility Leukocyte Migration Establishment Of Sertoli Cell Barrier Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Isotype Switching To IgG Isotypes Bone Marrow Development Virion Attachment To Host Cell Response To Virus Positive Regulation Of Gamma-delta T Cell Differentiation Acute Inflammatory Response To Antigenic Stimulus Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Regulation Of Isotype Switching To IgG Isotypes Adhesion Of Symbiont To Host
Tagcloud ?			a2 caucasians cd8a concepts controversial encode highlighted hla icam il1b il2 itgb2 loadings meta mining modifier nonrandomly pooled ranked retrieved sell selp shared silico spite synapses text top truly
Tagcloud (Difference) ?			a2 caucasians cd8a concepts controversial encode highlighted hla icam il1b il2 itgb2 loadings meta mining modifier nonrandomly pooled ranked retrieved sell selp shared silico spite synapses text top truly
Tagcloud (Intersection) ?