ICAM5

Description		intercellular adhesion molecule 5
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GO Annotations	Cellular Component	Plasma Membrane Membrane Postsynapse Glutamatergic Synapse
	Molecular Function	Integrin Binding Protein Binding
	Biological Process	Phagocytosis Cell Adhesion Regulation Of Synapse Assembly Cell-cell Adhesion
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Inflammatory skin disease ( 25574825) Lymphocyte percentage of white cells ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) White blood cell count ( 27863252)
Novel Interacting Genes		2 novel interacting genes: DOP1B SMARCA4
Interacting Genes		5 interacting genes: ACTN1 ITGAL ITGB2 PSEN1 PSEN2
Entrez ID		7087
HPRD ID		03509
Ensembl ID		ENSG00000105376
Uniprot IDs		Q8N6I2 Q9UMF0
PDB IDs		3BN3 4OI9 4OIA 4OIB
Enriched GO Terms of Interacting Partners?		Integrin AlphaL-beta2 Complex ICAM-3 Receptor Activity Aspartic Endopeptidase Activity, Intramembrane Cleaving Gamma-secretase Complex Notch Receptor Processing Amyloid-beta Formation Cell-cell Adhesion Cellular Extravasation Amyloid Precursor Protein Catabolic Process Neural Retina Development Kinetochore Membrane Protein Ectodomain Proteolysis Amyloid-beta Metabolic Process Amyloid Precursor Protein Metabolic Process Integrin Complex Cell Activation Membrane Protein Proteolysis Receptor Clustering Cell Adhesion Leukocyte Cell-cell Adhesion Synaptic Membrane T Cell Activation Involved In Immune Response Negative Regulation Of Core Promoter Binding Specific Granule Membrane Cell Adhesion Molecule Binding Phagocytosis Structural Constituent Of Postsynapse Memory T Cell Extravasation Integrin-mediated Signaling Pathway Cell-matrix Adhesion Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cajal-Retzius Cell Differentiation Notch Signaling Pathway Platelet Morphogenesis Leukocyte Activation Lymphocyte Activation Involved In Immune Response Positive Regulation Of Neutrophil Degranulation Myeloid Leukocyte Activation Protein Catabolic Process At Postsynapse Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Glucose Mediated Signaling Pathway Presynaptic Membrane Synaptic Vesicle Integrin Binding Membrane Leukocyte Activation Involved In Immune Response Cell-substrate Adhesion Cell Surface
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