PEX5 and DDO

Number of citations of the paper that reports this interaction (PubMedID 9820813)
37

Data Source:
BioGRID (pull down, unspecified method)
HPRD (in vivo, in vitro)

		PEX5	DDO
Description		peroxisomal biogenesis factor 5	D-aspartate oxidase
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Peroxisome Peroxisomal Membrane Peroxisomal Matrix Golgi Apparatus Cytosol Membrane Protein-containing Complex	Cytoplasm Peroxisome Peroxisomal Matrix Cytosol
	Molecular Function	Peroxisome Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Protein Binding Enzyme Binding Small GTPase Binding Peroxisome Membrane Targeting Sequence Binding Protein Carrier Chaperone	D-amino-acid Oxidase Activity Protein Binding D-aspartate Oxidase Activity Oxidoreductase Activity D-glutamate Oxidase Activity FAD Binding
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Pexophagy Neuron Migration Protein Monoubiquitination Protein Targeting To Peroxisome Lipid Metabolic Process Fatty Acid Beta-oxidation Mitochondrion Organization Mitochondrial Membrane Organization Endoplasmic Reticulum Organization Peroxisome Organization Protein Transport Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Receptor Recycling Cerebral Cortex Cell Migration Cerebral Cortex Neuron Differentiation Negative Regulation Of Protein-containing Complex Assembly Cellular Response To Reactive Oxygen Species Positive Regulation Of Multicellular Organism Growth Protein Unfolding Protein Import Into Peroxisome Matrix, Substrate Release Protein Import Into Peroxisome Membrane Cell Development Neuromuscular Process Protein Tetramerization	Aspartate Metabolic Process L-aspartate Catabolic Process Insemination Grooming Behavior Regulation Of Cell Communication D-amino Acid Catabolic Process Hormone Metabolic Process D-amino Acid Metabolic Process Nervous System Process L-amino Acid Catabolic Process Proteinogenic Amino Acid Catabolic Process
Pathways		Pexophagy	Glyoxylate metabolism and glycine degradation Peroxisomal protein import Peroxisomal protein import
Drugs
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		IgG glycosylation ( 23382691) Night sleep phenotypes ( 27126917) Refractive error ( 32231278)	Blood metabolite levels ( 26401656) Daytime sleep phenotypes ( 27126917) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 27863252 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Systemic lupus erythematosus ( 26502338)
Interacting Genes		77 interacting genes: ACD ACOT2 ACOT4 ACOT8 ACOX2 ACOX3 AGXT AMACR ANKRD50 ATM BAAT BRCA1 CAPRIN2 CCDC14 CROT DAO DDO DECR2 DHRS4 ECI2 EP400P1 EPHX2 GDPD5 GLMN GNPAT GSTK1 HACL1 HAO1 HAO2 HMGCL HNRNPH1 HOXA7 HSPA1A IDE IDH1 LDHB LONP2 MKRN3 MLYCD MPV17 NOS2 NUDT19 NUDT3 NUDT7 NUFIP2 PAOX PDZK1 PEX1 PEX10 PEX12 PEX13 PEX14 PEX26 PEX6 PEX7 PIPOX POT1 PRDX5 PRR13 PSAP RPL14 S100A6 SCARB1 SCP2 SCRN2 SIRT3 SLC27A2 SNUPN SSTR5 TIMMDC1 TINF2 TM6SF1 TOMM7 USP2 USP9X ZFAND3 ZNF772	2 interacting genes: COPS5 PEX5
Entrez ID		5830	8528
HPRD ID		02684	00498
Ensembl ID		ENSG00000139197	ENSG00000203797
Uniprot IDs		A0A0S2Z480 A0A0S2Z4F3 A0A0S2Z4H1 B4DR50 B4E0T2 P50542	Q99489
PDB IDs		1FCH 2C0L 2C0M 2J9Q 2W84 3R9A 4BXU 4KXK 4KYO 7Z0K 9GAG	6RKF
Enriched GO Terms of Interacting Partners?		Peroxisome Peroxisomal Matrix Carboxylic Acid Catabolic Process Establishment Of Protein Localization To Peroxisome Protein Import Into Peroxisome Matrix Fatty Acid Oxidation Carboxylic Acid Metabolic Process Fatty Acid Catabolic Process Organic Acid Metabolic Process Lipid Oxidation Peroxisome Organization Fatty Acid Metabolic Process Monocarboxylic Acid Metabolic Process Peroxisomal Membrane Transport Peroxisomal Membrane Lipid Modification Protein Import Into Peroxisome Matrix, Receptor Recycling Intracellular Protein Transmembrane Transport Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Small Molecule Metabolic Process Lipid Metabolic Process Protein Unfolding Lipid Catabolic Process Protein Transmembrane Transport Catabolic Process Fatty Acid Beta-oxidation Receptor Recycling Protein Targeting To Peroxisome Cytosol Establishment Of Protein Localization To Organelle Receptor Metabolic Process Sulfur Compound Metabolic Process Acyl-CoA Metabolic Process Bile Acid Biosynthetic Process Carboxylic Acid Biosynthetic Process Protein Import Into Peroxisome Matrix, Substrate Release Bile Acid Metabolic Process Fatty Acid Alpha-oxidation Oxidoreductase Activity Protein Localization To Organelle Purine-containing Compound Metabolic Process Small Molecule Biosynthetic Process Peroxisomal Importomer Complex Malonyl-CoA Catabolic Process Protein Transmembrane Transporter Activity Nucleoside Phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Protein Import Into Peroxisome Matrix, Translocation Telomere Assembly Organophosphate Metabolic Process	Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Membrane Enzyme Binding Peroxisome Membrane Targeting Sequence Binding Protein Import Into Peroxisome Matrix, Substrate Release Peroxisome Matrix Targeting Signal-1 Binding Peroxisome Targeting Sequence Binding Protein Import Into Peroxisome Matrix, Docking Exosomal Secretion Macrophage Migration Inhibitory Factor Binding DeNEDDylase Activity Post-translational Protein Modification Protein Unfolding Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Carrier Chaperone Peroxisomal Membrane Transport Establishment Of Protein Localization To Peroxisome Protein Modification By Small Protein Conjugation Protein Import Into Peroxisome Matrix Pexophagy Regulation Of Protein Neddylation Regulation Of IRE1-mediated Unfolded Protein Response Eukaryotic Translation Initiation Factor 3 Complex Protein Deneddylation Metal-dependent Deubiquitinase Activity Protein Neddylation Cerebral Cortex Neuron Differentiation Peroxisome Organization Receptor Recycling Intracellular Protein Transmembrane Transport Cerebral Cortex Cell Migration Positive Regulation Of Multicellular Organism Growth COP9 Signalosome Very Long-chain Fatty Acid Metabolic Process Regulation Of Endoplasmic Reticulum Unfolded Protein Response Forebrain Neuron Differentiation Telencephalon Cell Migration Forebrain Cell Migration Receptor Metabolic Process Peroxisomal Matrix Translation Initiation Factor Activity Fatty Acid Beta-oxidation Protein Monoubiquitination Endoplasmic Reticulum Organization Peroxisomal Membrane Regulation Of Multicellular Organism Growth Establishment Of Localization In Cell Protein Modification Process Protein Transmembrane Transport
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