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PEX5 and EP400P1
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
PEX5
EP400P1
Description
peroxisomal biogenesis factor 5
EP400 pseudogene 1
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Peroxisome
Peroxisomal Membrane
Peroxisomal Matrix
Golgi Apparatus
Cytosol
Membrane
Protein-containing Complex
Molecular Function
Peroxisome Targeting Sequence Binding
Peroxisome Matrix Targeting Signal-1 Binding
Protein Binding
Enzyme Binding
Small GTPase Binding
Peroxisome Membrane Targeting Sequence Binding
Protein Carrier Chaperone
Protein Binding
Biological Process
Very Long-chain Fatty Acid Metabolic Process
Pexophagy
Neuron Migration
Protein Monoubiquitination
Protein Targeting To Peroxisome
Lipid Metabolic Process
Fatty Acid Beta-oxidation
Mitochondrion Organization
Mitochondrial Membrane Organization
Endoplasmic Reticulum Organization
Peroxisome Organization
Protein Transport
Protein Import Into Peroxisome Matrix
Protein Import Into Peroxisome Matrix, Docking
Protein Import Into Peroxisome Matrix, Translocation
Protein Import Into Peroxisome Matrix, Receptor Recycling
Cerebral Cortex Cell Migration
Cerebral Cortex Neuron Differentiation
Negative Regulation Of Protein-containing Complex Assembly
Cellular Response To Reactive Oxygen Species
Positive Regulation Of Multicellular Organism Growth
Protein Unfolding
Protein Import Into Peroxisome Matrix, Substrate Release
Protein Import Into Peroxisome Membrane
Cell Development
Neuromuscular Process
Protein Tetramerization
Pathways
Pexophagy
Drugs
Diseases
Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS
IgG glycosylation (
23382691
)
Night sleep phenotypes (
27126917
)
Refractive error (
32231278
)
Interacting Genes
77 interacting genes:
ACD
ACOT2
ACOT4
ACOT8
ACOX2
ACOX3
AGXT
AMACR
ANKRD50
ATM
BAAT
BRCA1
CAPRIN2
CCDC14
CROT
DAO
DDO
DECR2
DHRS4
ECI2
EP400P1
EPHX2
GDPD5
GLMN
GNPAT
GSTK1
HACL1
HAO1
HAO2
HMGCL
HNRNPH1
HOXA7
HSPA1A
IDE
IDH1
LDHB
LONP2
MKRN3
MLYCD
MPV17
NOS2
NUDT19
NUDT3
NUDT7
NUFIP2
PAOX
PDZK1
PEX1
PEX10
PEX12
PEX13
PEX14
PEX26
PEX6
PEX7
PIPOX
POT1
PRDX5
PRR13
PSAP
RPL14
S100A6
SCARB1
SCP2
SCRN2
SIRT3
SLC27A2
SNUPN
SSTR5
TIMMDC1
TINF2
TM6SF1
TOMM7
USP2
USP9X
ZFAND3
ZNF772
5 interacting genes:
APP
BRD8
CEP76
FBXO7
PEX5
Entrez ID
5830
347918
HPRD ID
02684
13413
Ensembl ID
ENSG00000139197
ENSG00000291171
Uniprot IDs
A0A0S2Z480
A0A0S2Z4F3
A0A0S2Z4H1
B4DR50
B4E0T2
P50542
PDB IDs
1FCH
2C0L
2C0M
2J9Q
2W84
3R9A
4BXU
4KXK
4KYO
7Z0K
9GAG
Enriched GO Terms of Interacting Partners
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Peroxisome
Peroxisomal Matrix
Carboxylic Acid Catabolic Process
Establishment Of Protein Localization To Peroxisome
Protein Import Into Peroxisome Matrix
Fatty Acid Oxidation
Carboxylic Acid Metabolic Process
Fatty Acid Catabolic Process
Organic Acid Metabolic Process
Lipid Oxidation
Peroxisome Organization
Fatty Acid Metabolic Process
Monocarboxylic Acid Metabolic Process
Peroxisomal Membrane Transport
Peroxisomal Membrane
Lipid Modification
Protein Import Into Peroxisome Matrix, Receptor Recycling
Intracellular Protein Transmembrane Transport
Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase
Small Molecule Metabolic Process
Lipid Metabolic Process
Protein Unfolding
Lipid Catabolic Process
Protein Transmembrane Transport
Catabolic Process
Fatty Acid Beta-oxidation
Receptor Recycling
Protein Targeting To Peroxisome
Cytosol
Establishment Of Protein Localization To Organelle
Receptor Metabolic Process
Sulfur Compound Metabolic Process
Acyl-CoA Metabolic Process
Bile Acid Biosynthetic Process
Carboxylic Acid Biosynthetic Process
Protein Import Into Peroxisome Matrix, Substrate Release
Bile Acid Metabolic Process
Fatty Acid Alpha-oxidation
Oxidoreductase Activity
Protein Localization To Organelle
Purine-containing Compound Metabolic Process
Small Molecule Biosynthetic Process
Peroxisomal Importomer Complex
Malonyl-CoA Catabolic Process
Protein Transmembrane Transporter Activity
Nucleoside Phosphate Metabolic Process
Nucleobase-containing Small Molecule Metabolic Process
Protein Import Into Peroxisome Matrix, Translocation
Telomere Assembly
Organophosphate Metabolic Process
Protein-containing Complex
Amyloid-beta Complex
Growth Cone Lamellipodium
Regulation Of Response To Calcium Ion
Regulation Of Multicellular Organism Growth
Amylin Binding
Protein Tetramerization
Positive Regulation Of Toll Signaling Pathway
Regulation Of Cell Cycle
Glial Cytoplasmic Inclusion
Classical Lewy Body
Lewy Body Corona
Lewy Neurite
Mitochondrion
Acetylcholine Receptor Activator Activity
PTB Domain Binding
Collateral Sprouting In Absence Of Injury
Regulation Of Protein Import
Endosome To Plasma Membrane Transport Vesicle
Positive Regulation Of Endothelin Production
Growth Cone Filopodium
Lipoprotein Particle
Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Protein Import
Microglia Development
Positive Regulation Of G Protein-coupled Receptor Internalization
Peroxisome Membrane Targeting Sequence Binding
Peroxisome Matrix Targeting Signal-1 Binding
Peroxisome Targeting Sequence Binding
Lewy Body Core
Response To Norepinephrine
Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Regulation Of Intrinsic Apoptotic Signaling Pathway
Cellular Response To Norepinephrine Stimulus
Astrocyte Activation Involved In Immune Response
Low-density Lipoprotein Particle Mediated Signaling
Protein Import Into Peroxisome Matrix, Translocation
Protein Import Into Peroxisome Matrix, Docking
Intermediate-density Lipoprotein Particle
Axon Midline Choice Point Recognition
Positive Regulation Of Amyloid Fibril Formation
Growth Factor Receptor Binding
Main Axon
Protein Targeting
Regulation Of Spontaneous Synaptic Transmission
NMDA Selective Glutamate Receptor Signaling Pathway
Regulation Of Synapse Structure Or Activity
Regulation Of Toll Signaling Pathway
Protein Import Into Peroxisome Membrane
Protein Import Into Peroxisome Matrix, Substrate Release
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